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PID1 (phosphotyrosine interaction domain containing 1)

Identity

Alias_symbol (synonym)NYGGF4
FLJ20701
Other aliasHMFN2073
P-CLI1
PCLI1
HGNC (Hugo) PID1
LocusID (NCBI) 55022
Atlas_Id 50893
Location 2q36.3  [Link to chromosome band 2q36]
Location_base_pair Starts at 229023973 and ends at 229271341 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NCAM2 (21q21.1) / PID1 (2q36.3)PID1 (2q36.3) / ANKS1B (12q23.1)PID1 (2q36.3) / DNER (2q36.3)
PID1 (2q36.3) / SKIL (3q26.2)SPTLC2 (14q24.3) / PID1 (2q36.3)UCK2 (1q24.1) / PID1 (2q36.3)
PID1 2q36.3 / DNER 2q36.3SPTLC2 14q24.3 / PID1 2q36.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PID1   26084
Cards
Entrez_Gene (NCBI)PID1  55022  phosphotyrosine interaction domain containing 1
AliasesHMFN2073; NYGGF4; P-CLI1; PCLI1
GeneCards (Weizmann)PID1
Ensembl hg19 (Hinxton)ENSG00000153823 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153823 [Gene_View]  chr2:229023973-229271341 [Contig_View]  PID1 [Vega]
ICGC DataPortalENSG00000153823
TCGA cBioPortalPID1
AceView (NCBI)PID1
Genatlas (Paris)PID1
WikiGenes55022
SOURCE (Princeton)PID1
Genetics Home Reference (NIH)PID1
Genomic and cartography
GoldenPath hg38 (UCSC)PID1  -     chr2:229023973-229271341 -  2q36.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PID1  -     2q36.3   [Description]    (hg19-Feb_2009)
EnsemblPID1 - 2q36.3 [CytoView hg19]  PID1 - 2q36.3 [CytoView hg38]
Mapping of homologs : NCBIPID1 [Mapview hg19]  PID1 [Mapview hg38]
OMIM612930   
Gene and transcription
Genbank (Entrez)AB075874 AK000708 AK096636 AK125359 AY317148
RefSeq transcript (Entrez)NM_001100818 NM_001330156 NM_001330157 NM_001330158 NM_017933
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PID1
Cluster EST : UnigeneHs.745038 [ NCBI ]
CGAP (NCI)Hs.745038
Alternative Splicing GalleryENSG00000153823
Gene ExpressionPID1 [ NCBI-GEO ]   PID1 [ EBI - ARRAY_EXPRESS ]   PID1 [ SEEK ]   PID1 [ MEM ]
Gene Expression Viewer (FireBrowse)PID1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55022
GTEX Portal (Tissue expression)PID1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z2X4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z2X4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z2X4
Splice isoforms : SwissVarQ7Z2X4
PhosPhoSitePlusQ7Z2X4
Domaine pattern : Prosite (Expaxy)PID (PS01179)   
Domains : Interpro (EBI)PH_dom-like    PTB/PI_dom   
Domain families : Pfam (Sanger)PID_2 (PF14719)   
Domain families : Pfam (NCBI)pfam14719   
Domain families : Smart (EMBL)PTB (SM00462)  
Conserved Domain (NCBI)PID1
DMDM Disease mutations55022
Blocks (Seattle)PID1
SuperfamilyQ7Z2X4
Human Protein AtlasENSG00000153823
Peptide AtlasQ7Z2X4
HPRD07944
IPIIPI00384947   IPI00792193   IPI00827514   IPI00744724   IPI01013937   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z2X4
IntAct (EBI)Q7Z2X4
FunCoupENSG00000153823
BioGRIDPID1
STRING (EMBL)PID1
ZODIACPID1
Ontologies - Pathways
QuickGOQ7Z2X4
Ontology : AmiGOnegative regulation of protein phosphorylation  protein binding  cytoplasm  energy reserve metabolic process  positive regulation of gene expression  regulation of mitochondrial fusion  cellular response to leptin stimulus  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  negative regulation of insulin receptor signaling pathway  regulation of mitochondrial membrane potential  regulation of mitochondrial membrane potential  positive regulation of fat cell proliferation  mitochondrion morphogenesis  cellular response to cytokine stimulus  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to fatty acid  negative regulation of establishment of protein localization to plasma membrane  negative regulation of mitochondrial DNA replication  regulation of G1/S transition of mitotic cell cycle  regulation of reactive oxygen species metabolic process  positive regulation of reactive oxygen species metabolic process  negative regulation of ATP biosynthetic process  positive regulation of ATP biosynthetic process  negative regulation of glucose import in response to insulin stimulus  
Ontology : EGO-EBInegative regulation of protein phosphorylation  protein binding  cytoplasm  energy reserve metabolic process  positive regulation of gene expression  regulation of mitochondrial fusion  cellular response to leptin stimulus  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  negative regulation of insulin receptor signaling pathway  regulation of mitochondrial membrane potential  regulation of mitochondrial membrane potential  positive regulation of fat cell proliferation  mitochondrion morphogenesis  cellular response to cytokine stimulus  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to fatty acid  negative regulation of establishment of protein localization to plasma membrane  negative regulation of mitochondrial DNA replication  regulation of G1/S transition of mitotic cell cycle  regulation of reactive oxygen species metabolic process  positive regulation of reactive oxygen species metabolic process  negative regulation of ATP biosynthetic process  positive regulation of ATP biosynthetic process  negative regulation of glucose import in response to insulin stimulus  
NDEx NetworkPID1
Atlas of Cancer Signalling NetworkPID1
Wikipedia pathwaysPID1
Orthology - Evolution
OrthoDB55022
GeneTree (enSembl)ENSG00000153823
Phylogenetic Trees/Animal Genes : TreeFamPID1
HOVERGENQ7Z2X4
HOGENOMQ7Z2X4
Homologs : HomoloGenePID1
Homology/Alignments : Family Browser (UCSC)PID1
Gene fusions - Rearrangements
Fusion : MitelmanPID1/DNER [2q36.3/2q36.3]  
Fusion : MitelmanSPTLC2/PID1 [14q24.3/2q36.3]  [t(2;14)(q36;q24)]  
Fusion: TCGAPID1 2q36.3 DNER 2q36.3 LUAD
Fusion: TCGASPTLC2 14q24.3 PID1 2q36.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPID1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PID1
dbVarPID1
ClinVarPID1
1000_GenomesPID1 
Exome Variant ServerPID1
ExAC (Exome Aggregation Consortium)PID1 (select the gene name)
Genetic variants : HAPMAP55022
Genomic Variants (DGV)PID1 [DGVbeta]
DECIPHERPID1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPID1 
Mutations
ICGC Data PortalPID1 
TCGA Data PortalPID1 
Broad Tumor PortalPID1
OASIS PortalPID1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPID1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPID1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PID1
DgiDB (Drug Gene Interaction Database)PID1
DoCM (Curated mutations)PID1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PID1 (select a term)
intoGenPID1
Cancer3DPID1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612930   
Orphanet
MedgenPID1
Genetic Testing Registry PID1
NextProtQ7Z2X4 [Medical]
TSGene55022
GENETestsPID1
Target ValidationPID1
Huge Navigator PID1 [HugePedia]
snp3D : Map Gene to Disease55022
BioCentury BCIQPID1
ClinGenPID1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55022
Chemical/Pharm GKB GenePA162399462
Clinical trialPID1
Miscellaneous
canSAR (ICR)PID1 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePID1
EVEXPID1
GoPubMedPID1
iHOPPID1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:24:44 CEST 2017

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