PIDD1 (p53-induced death domain protein 1)

2014-05-01  

Identity

HGNC
PIDD1
LOCATION
11p15.5
LOCUSID
55367
ALIAS
LRDD,PIDD

Other Information

Locus ID:

NCBI: 55367
MIM: 605247
HGNC: 16491
Ensembl: ENSG00000177595

Variants:

dbSNP: 55367
ClinVar: 55367
TCGA: ENSG00000177595
COSMIC: PIDD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177595ENST00000347755Q9HB75
ENSG00000177595ENST00000411829Q9HB75
ENSG00000177595ENST00000524486E9PPT6
ENSG00000177595ENST00000525028E9PPT6
ENSG00000177595ENST00000531286H0YE55

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Caspase Activators and CaspasesREACTOMER-HSA-6803207

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
150733212004The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.198
163600372005PIDD mediates NF-kappaB activation in response to DNA damage.122
171599002007Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.64
182388952008A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.34
228545982012PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.31
176377552008p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress.22
284320802017NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.14
214158622011PIDD orchestrates translesion DNA synthesis in response to UV irradiation.12
169820332006Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin.11
209669612011Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90.9

Citation

Dessen P

PIDD1 (p53-induced death domain protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/52253/pidd1