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PIEZO2 (piezo type mechanosensitive ion channel component 2)

Identity

Alias_namesFAM38B2
C18orf30
C18orf58
FAM38B
chromosome 18 open reading frame 30
chromosome 18 open reading frame 58
family with sequence similarity 38, member B
piezo-type mechanosensitive ion channel component 2
Alias_symbol (synonym)FLJ23403
FLJ23144
HsT748
HsT771
FLJ34907
Other aliasDA3
DA5
DAIPT
MWKS
HGNC (Hugo) PIEZO2
LocusID (NCBI) 63895
Atlas_Id 71906
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 10670247 and ends at 11148762 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PIEZO2 (18p11.22) / ALG12 (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIEZO2   26270
Cards
Entrez_Gene (NCBI)PIEZO2  63895  piezo type mechanosensitive ion channel component 2
AliasesC18orf30; C18orf58; DA3; DA5; 
DAIPT; FAM38B; FAM38B2; HsT748; HsT771; MWKS
GeneCards (Weizmann)PIEZO2
Ensembl hg19 (Hinxton)ENSG00000154864 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154864 [Gene_View]  chr18:10670247-11148762 [Contig_View]  PIEZO2 [Vega]
ICGC DataPortalENSG00000154864
TCGA cBioPortalPIEZO2
AceView (NCBI)PIEZO2
Genatlas (Paris)PIEZO2
WikiGenes63895
SOURCE (Princeton)PIEZO2
Genetics Home Reference (NIH)PIEZO2
Genomic and cartography
GoldenPath hg38 (UCSC)PIEZO2  -     chr18:10670247-11148762 -  18p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIEZO2  -     18p11.22   [Description]    (hg19-Feb_2009)
EnsemblPIEZO2 - 18p11.22 [CytoView hg19]  PIEZO2 - 18p11.22 [CytoView hg38]
Mapping of homologs : NCBIPIEZO2 [Mapview hg19]  PIEZO2 [Mapview hg38]
OMIM108145   114300   248700   613629   617146   
Gene and transcription
Genbank (Entrez)AK026797 AK027056 AK092226 AK095053 AK127627
RefSeq transcript (Entrez)NM_022068 NM_173817
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIEZO2
Cluster EST : UnigeneHs.436902 [ NCBI ]
CGAP (NCI)Hs.436902
Alternative Splicing GalleryENSG00000154864
Gene ExpressionPIEZO2 [ NCBI-GEO ]   PIEZO2 [ EBI - ARRAY_EXPRESS ]   PIEZO2 [ SEEK ]   PIEZO2 [ MEM ]
Gene Expression Viewer (FireBrowse)PIEZO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)63895
GTEX Portal (Tissue expression)PIEZO2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H5I5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H5I5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H5I5
Splice isoforms : SwissVarQ9H5I5
PhosPhoSitePlusQ9H5I5
Domains : Interpro (EBI)Piezo    Piezo_dom    Piezo_RRas-bd_dom   
Domain families : Pfam (Sanger)PIEZO (PF15917)    Piezo_RRas_bdg (PF12166)   
Domain families : Pfam (NCBI)pfam15917    pfam12166   
Conserved Domain (NCBI)PIEZO2
DMDM Disease mutations63895
Blocks (Seattle)PIEZO2
SuperfamilyQ9H5I5
Human Protein AtlasENSG00000154864
Peptide AtlasQ9H5I5
HPRD07636
IPIIPI00642845   IPI00791071   IPI00640526   IPI00974143   IPI00944547   IPI00944524   IPI00004963   
Protein Interaction databases
DIP (DOE-UCLA)Q9H5I5
IntAct (EBI)Q9H5I5
FunCoupENSG00000154864
BioGRIDPIEZO2
STRING (EMBL)PIEZO2
ZODIACPIEZO2
Ontologies - Pathways
QuickGOQ9H5I5
Ontology : AmiGOcation channel activity  plasma membrane  cation transport  mechanically-gated ion channel activity  response to mechanical stimulus  integral component of membrane  regulation of membrane potential  detection of mechanical stimulus involved in sensory perception  detection of mechanical stimulus  cellular response to mechanical stimulus  cation transmembrane transport  
Ontology : EGO-EBIcation channel activity  plasma membrane  cation transport  mechanically-gated ion channel activity  response to mechanical stimulus  integral component of membrane  regulation of membrane potential  detection of mechanical stimulus involved in sensory perception  detection of mechanical stimulus  cellular response to mechanical stimulus  cation transmembrane transport  
NDEx NetworkPIEZO2
Atlas of Cancer Signalling NetworkPIEZO2
Wikipedia pathwaysPIEZO2
Orthology - Evolution
OrthoDB63895
GeneTree (enSembl)ENSG00000154864
Phylogenetic Trees/Animal Genes : TreeFamPIEZO2
HOVERGENQ9H5I5
HOGENOMQ9H5I5
Homologs : HomoloGenePIEZO2
Homology/Alignments : Family Browser (UCSC)PIEZO2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIEZO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIEZO2
dbVarPIEZO2
ClinVarPIEZO2
1000_GenomesPIEZO2 
Exome Variant ServerPIEZO2
ExAC (Exome Aggregation Consortium)PIEZO2 (select the gene name)
Genetic variants : HAPMAP63895
Genomic Variants (DGV)PIEZO2 [DGVbeta]
DECIPHERPIEZO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIEZO2 
Mutations
ICGC Data PortalPIEZO2 
TCGA Data PortalPIEZO2 
Broad Tumor PortalPIEZO2
OASIS PortalPIEZO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIEZO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIEZO2
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIEZO2
DgiDB (Drug Gene Interaction Database)PIEZO2
DoCM (Curated mutations)PIEZO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIEZO2 (select a term)
intoGenPIEZO2
Cancer3DPIEZO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108145    114300    248700    613629    617146   
Orphanet424    2007    2273   
MedgenPIEZO2
Genetic Testing Registry PIEZO2
NextProtQ9H5I5 [Medical]
TSGene63895
GENETestsPIEZO2
Target ValidationPIEZO2
Huge Navigator PIEZO2 [HugePedia]
snp3D : Map Gene to Disease63895
BioCentury BCIQPIEZO2
ClinGenPIEZO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD63895
Chemical/Pharm GKB GenePA134930761
Clinical trialPIEZO2
Miscellaneous
canSAR (ICR)PIEZO2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIEZO2
EVEXPIEZO2
GoPubMedPIEZO2
iHOPPIEZO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:34:31 CEST 2017

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