PIF1 (PIF1 5-to-3 DNA helicase)

2011-10-01  

Identity

HGNC
PIF1
LOCATION
15q22.31
LOCUSID
80119
ALIAS
C15orf20,PIF

Other Information

Locus ID:

NCBI: 80119
MIM: 610953
HGNC: 26220
Ensembl: ENSG00000140451

Variants:

dbSNP: 80119
ClinVar: 80119
TCGA: ENSG00000140451
COSMIC: PIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140451ENST00000268043Q9H611
ENSG00000140451ENST00000333425Q9H611
ENSG00000140451ENST00000559239Q9H611

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
236572612013Pif1 family helicases suppress genome instability at G-quadruplex motifs.177
205249332010Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity.66
165226492006The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity.40
178277212007Mitochondrial and nuclear localization of human Pif1 helicase.36
171728552006Human PIF helicase is cell cycle regulated and associates with telomerase.33
197007732009Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks.31
235960082013Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA.24
255897862015A parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase.24
188358532008Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain.21
223474002012A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1.21

Citation

Dessen P

PIF1 (PIF1 5-to-3 DNA helicase)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52460/pif1