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PIGL (phosphatidylinositol glycan anchor biosynthesis class L)

Identity

Alias_namesphosphatidylinositol glycan
Other aliasCHIME
HGNC (Hugo) PIGL
LocusID (NCBI) 9487
Atlas_Id 41710
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 16217195 and ends at 16326259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FN1 (2q35) / PIGL (17p11.2)PIGL (17p11.2) / RABEP1 (17p13.2)PIGL (17p11.2) / TBC1D26 (17p12)
RABEP1 (17p13.2) / PIGL (17p11.2)RNF167 (17p13.2) / PIGL (17p11.2)PIGL 17p11.2 / TBC1D26 17p12
RABEP1 17p13.2 / PIGL 17p11.2RNF167 17p13.2 / PIGL 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PIGL   8966
Cards
Entrez_Gene (NCBI)PIGL  9487  phosphatidylinositol glycan anchor biosynthesis class L
AliasesCHIME
GeneCards (Weizmann)PIGL
Ensembl hg19 (Hinxton)ENSG00000108474 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108474 [Gene_View]  chr17:16217195-16326259 [Contig_View]  PIGL [Vega]
ICGC DataPortalENSG00000108474
TCGA cBioPortalPIGL
AceView (NCBI)PIGL
Genatlas (Paris)PIGL
WikiGenes9487
SOURCE (Princeton)PIGL
Genetics Home Reference (NIH)PIGL
Genomic and cartography
GoldenPath hg38 (UCSC)PIGL  -     chr17:16217195-16326259 +  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIGL  -     17p11.2   [Description]    (hg19-Feb_2009)
EnsemblPIGL - 17p11.2 [CytoView hg19]  PIGL - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIPIGL [Mapview hg19]  PIGL [Mapview hg38]
OMIM280000   605947   
Gene and transcription
Genbank (Entrez)AB017165 AI888858 AK023469 AK292932 AK296120
RefSeq transcript (Entrez)NM_004278
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIGL
Cluster EST : UnigeneHs.625050 [ NCBI ]
CGAP (NCI)Hs.625050
Alternative Splicing GalleryENSG00000108474
Gene ExpressionPIGL [ NCBI-GEO ]   PIGL [ EBI - ARRAY_EXPRESS ]   PIGL [ SEEK ]   PIGL [ MEM ]
Gene Expression Viewer (FireBrowse)PIGL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9487
GTEX Portal (Tissue expression)PIGL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2B2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2B2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2B2
Splice isoforms : SwissVarQ9Y2B2
Catalytic activity : Enzyme3.5.1.89 [ Enzyme-Expasy ]   3.5.1.893.5.1.89 [ IntEnz-EBI ]   3.5.1.89 [ BRENDA ]   3.5.1.89 [ KEGG ]   
PhosPhoSitePlusQ9Y2B2
Domains : Interpro (EBI)GlcNAc_PI_deacetylase-related    LmbE-like_dom   
Domain families : Pfam (Sanger)PIG-L (PF02585)   
Domain families : Pfam (NCBI)pfam02585   
Conserved Domain (NCBI)PIGL
DMDM Disease mutations9487
Blocks (Seattle)PIGL
SuperfamilyQ9Y2B2
Human Protein AtlasENSG00000108474
Peptide AtlasQ9Y2B2
HPRD12071
IPIIPI00032002   IPI00796457   IPI00789372   IPI00793253   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2B2
IntAct (EBI)Q9Y2B2
FunCoupENSG00000108474
BioGRIDPIGL
STRING (EMBL)PIGL
ZODIACPIGL
Ontologies - Pathways
QuickGOQ9Y2B2
Ontology : AmiGON-acetylglucosaminylphosphatidylinositol deacetylase activity  N-acetylglucosaminylphosphatidylinositol deacetylase activity  endoplasmic reticulum membrane  GPI anchor biosynthetic process  integral component of membrane  preassembly of GPI anchor in ER membrane  
Ontology : EGO-EBIN-acetylglucosaminylphosphatidylinositol deacetylase activity  N-acetylglucosaminylphosphatidylinositol deacetylase activity  endoplasmic reticulum membrane  GPI anchor biosynthetic process  integral component of membrane  preassembly of GPI anchor in ER membrane  
Pathways : KEGGGlycosylphosphatidylinositol(GPI)-anchor biosynthesis   
NDEx NetworkPIGL
Atlas of Cancer Signalling NetworkPIGL
Wikipedia pathwaysPIGL
Orthology - Evolution
OrthoDB9487
GeneTree (enSembl)ENSG00000108474
Phylogenetic Trees/Animal Genes : TreeFamPIGL
HOVERGENQ9Y2B2
HOGENOMQ9Y2B2
Homologs : HomoloGenePIGL
Homology/Alignments : Family Browser (UCSC)PIGL
Gene fusions - Rearrangements
Fusion : MitelmanPIGL/RABEP1 [17p11.2/17p13.2]  
Fusion : MitelmanPIGL/TBC1D26 [17p11.2/17p12]  [t(17;17)(p11;p12)]  
Fusion : MitelmanRABEP1/PIGL [17p13.2/17p11.2]  [t(17;17)(p11;p13)]  
Fusion : MitelmanRNF167/PIGL [17p13.2/17p11.2]  [t(17;17)(p11;p13)]  
Fusion: TCGAPIGL 17p11.2 TBC1D26 17p12 BRCA
Fusion: TCGARABEP1 17p13.2 PIGL 17p11.2 LUSC
Fusion: TCGARNF167 17p13.2 PIGL 17p11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIGL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIGL
dbVarPIGL
ClinVarPIGL
1000_GenomesPIGL 
Exome Variant ServerPIGL
ExAC (Exome Aggregation Consortium)PIGL (select the gene name)
Genetic variants : HAPMAP9487
Genomic Variants (DGV)PIGL [DGVbeta]
DECIPHERPIGL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIGL 
Mutations
ICGC Data PortalPIGL 
TCGA Data PortalPIGL 
Broad Tumor PortalPIGL
OASIS PortalPIGL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIGL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIGL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch PIGL
DgiDB (Drug Gene Interaction Database)PIGL
DoCM (Curated mutations)PIGL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIGL (select a term)
intoGenPIGL
Cancer3DPIGL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM280000    605947   
Orphanet19518    3498   
MedgenPIGL
Genetic Testing Registry PIGL
NextProtQ9Y2B2 [Medical]
TSGene9487
GENETestsPIGL
Target ValidationPIGL
Huge Navigator PIGL [HugePedia]
snp3D : Map Gene to Disease9487
BioCentury BCIQPIGL
ClinGenPIGL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9487
Chemical/Pharm GKB GenePA33297
Clinical trialPIGL
Miscellaneous
canSAR (ICR)PIGL (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIGL
EVEXPIGL
GoPubMedPIGL
iHOPPIGL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:49:26 CEST 2017

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