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PIGM (phosphatidylinositol glycan anchor biosynthesis class M)

Identity

Alias (NCBI)GPI-MT-I
HGNC (Hugo) PIGM
HGNC Alias symbGPI-MT-I
HGNC Alias nameGPI mannosyltransferase 1
 DPM:GlcN-(acyl-)PI mannosyltransferase
 dol-P-Man dependent GPI mannosyltransferase
HGNC Previous namephosphatidylinositol glycan, class M
LocusID (NCBI) 93183
Atlas_Id 47094
Location 1q23.2  [Link to chromosome band 1q23]
Location_base_pair Starts at 160024953 and ends at 160031990 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KRTCAP2 (1q22) / PIGM (1q23.2)PIGM (1q23.2) / ZBTB7C (18q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PIGM   18858
Cards
Entrez_Gene (NCBI)PIGM    phosphatidylinositol glycan anchor biosynthesis class M
AliasesGPI-MT-I
GeneCards (Weizmann)PIGM
Ensembl hg19 (Hinxton)ENSG00000143315 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143315 [Gene_View]  ENSG00000143315 [Sequence]  chr1:160024953-160031990 [Contig_View]  PIGM [Vega]
ICGC DataPortalENSG00000143315
TCGA cBioPortalPIGM
AceView (NCBI)PIGM
Genatlas (Paris)PIGM
SOURCE (Princeton)PIGM
Genetics Home Reference (NIH)PIGM
Genomic and cartography
GoldenPath hg38 (UCSC)PIGM  -     chr1:160024953-160031990 -  1q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIGM  -     1q23.2   [Description]    (hg19-Feb_2009)
GoldenPathPIGM - 1q23.2 [CytoView hg19]  PIGM - 1q23.2 [CytoView hg38]
ImmunoBaseENSG00000143315
Genome Data Viewer NCBIPIGM [Mapview hg19]  
OMIM610273   610293   
Gene and transcription
Genbank (Entrez)AB028127 AK074655 BC001803 BC011395 BC019865
RefSeq transcript (Entrez)NM_145167
Consensus coding sequences : CCDS (NCBI)PIGM
Gene ExpressionPIGM [ NCBI-GEO ]   PIGM [ EBI - ARRAY_EXPRESS ]   PIGM [ SEEK ]   PIGM [ MEM ]
Gene Expression Viewer (FireBrowse)PIGM [ Firebrowse - Broad ]
GenevisibleExpression of PIGM in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)93183
GTEX Portal (Tissue expression)PIGM
Human Protein AtlasENSG00000143315-PIGM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3S5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3S5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3S5
Catalytic activity : Enzyme2.4.1.- [ Enzyme-Expasy ]   2.4.1.-2.4.1.- [ IntEnz-EBI ]   2.4.1.- [ BRENDA ]   2.4.1.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H3S5
Domains : Interpro (EBI)PIG-M   
Domain families : Pfam (Sanger)Mannosyl_trans (PF05007)   
Domain families : Pfam (NCBI)pfam05007   
Conserved Domain (NCBI)PIGM
SuperfamilyQ9H3S5
AlphaFold pdb e-kbQ9H3S5   
Human Protein Atlas [tissue]ENSG00000143315-PIGM [tissue]
HPRD15133
Protein Interaction databases
DIP (DOE-UCLA)Q9H3S5
IntAct (EBI)Q9H3S5
BioGRIDPIGM
STRING (EMBL)PIGM
ZODIACPIGM
Ontologies - Pathways
QuickGOQ9H3S5
Ontology : AmiGOmannosyltransferase activity  glycolipid mannosyltransferase activity  endoplasmic reticulum membrane  GPI anchor biosynthetic process  integral component of membrane  preassembly of GPI anchor in ER membrane  alpha-1,4-mannosyltransferase activity  mannosylation  glycosylphosphatidylinositol-mannosyltransferase I complex  
Ontology : EGO-EBImannosyltransferase activity  glycolipid mannosyltransferase activity  endoplasmic reticulum membrane  GPI anchor biosynthetic process  integral component of membrane  preassembly of GPI anchor in ER membrane  alpha-1,4-mannosyltransferase activity  mannosylation  glycosylphosphatidylinositol-mannosyltransferase I complex  
Pathways : KEGGGlycosylphosphatidylinositol(GPI)-anchor biosynthesis   
NDEx NetworkPIGM
Atlas of Cancer Signalling NetworkPIGM
Wikipedia pathwaysPIGM
Orthology - Evolution
OrthoDB93183
GeneTree (enSembl)ENSG00000143315
Phylogenetic Trees/Animal Genes : TreeFamPIGM
Homologs : HomoloGenePIGM
Homology/Alignments : Family Browser (UCSC)PIGM
Gene fusions - Rearrangements
Fusion : QuiverPIGM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIGM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIGM
dbVarPIGM
ClinVarPIGM
MonarchPIGM
1000_GenomesPIGM 
Exome Variant ServerPIGM
GNOMAD BrowserENSG00000143315
Varsome BrowserPIGM
ACMGPIGM variants
VarityQ9H3S5
Genomic Variants (DGV)PIGM [DGVbeta]
DECIPHERPIGM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIGM 
Mutations
ICGC Data PortalPIGM 
TCGA Data PortalPIGM 
Broad Tumor PortalPIGM
OASIS PortalPIGM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIGM  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIGM
Mutations and Diseases : HGMDPIGM
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPIGM
DgiDB (Drug Gene Interaction Database)PIGM
DoCM (Curated mutations)PIGM
CIViC (Clinical Interpretations of Variants in Cancer)PIGM
Cancer3DPIGM
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610273    610293   
Orphanet11601   
DisGeNETPIGM
MedgenPIGM
Genetic Testing Registry PIGM
NextProtQ9H3S5 [Medical]
GENETestsPIGM
Target ValidationPIGM
Huge Navigator PIGM [HugePedia]
ClinGenPIGM
Clinical trials, drugs, therapy
MyCancerGenomePIGM
Protein Interactions : CTDPIGM
Pharm GKB GenePA38718
PharosQ9H3S5
Clinical trialPIGM
Miscellaneous
canSAR (ICR)PIGM
HarmonizomePIGM
DataMed IndexPIGM
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIGM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:17 CEST 2021

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