PIGR (polymeric immunoglobulin receptor)

2007-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5284
MIM: 173880
HGNC: 8968
Ensembl: ENSG00000162896

Variants:

dbSNP: 5284
ClinVar: 5284
TCGA: ENSG00000162896
COSMIC: PIGR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162896ENST00000356495P01833

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160485432005The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces.130
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
146606172004Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium.34
250781202014Polymeric immunoglobulin receptor down-regulation in chronic obstructive pulmonary disease. Persistence in the cultured epithelium and role of transforming growth factor-β.32
159726712005Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.28
220256222011The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.20
136793682003The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4.19
285150752017pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.19
162723252005Structural requirements for the interaction of human IgA with the human polymeric Ig receptor.18
117148072001A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor.16

Citation

Dessen P

PIGR (polymeric immunoglobulin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46253/pigr