PIH1D1 (PIH1 domain containing 1)

2014-11-01  

Identity

HGNC
PIH1D1
LOCATION
19q13.33
LOCUSID
55011
ALIAS
DNAAF14,MOT48,NOP17,Pih1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55011
MIM: 611480
HGNC: 26075
Ensembl: ENSG00000104872

Variants:

dbSNP: 55011
ClinVar: 55011
TCGA: ENSG00000104872
COSMIC: PIH1D1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104872ENST00000262265Q9NWS0
ENSG00000104872ENST00000594845M0QZ61
ENSG00000104872ENST00000595550M0R2H3
ENSG00000104872ENST00000596049Q9NWS0
ENSG00000104872ENST00000596651M0QZM3
ENSG00000104872ENST00000596916M0R1R3
ENSG00000104872ENST00000597415M0QYF4
ENSG00000104872ENST00000597577M0R2P8
ENSG00000104872ENST00000598175M0QZZ1
ENSG00000104872ENST00000598889M0R028
ENSG00000104872ENST00000599366M0QXD5
ENSG00000104872ENST00000600875M0R3A4
ENSG00000104872ENST00000601053M0R3A8
ENSG00000104872ENST00000601807M0QYA2
ENSG00000104872ENST00000601825M0R0J2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194506872009High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.42
246568132014Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.25
210783002010PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis.9
231596232013RPAP3 splicing variant isoform 1 interacts with PIH1D1 to compose R2TP complex for cell survival.8
240364512013PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.7
300332182018Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex.6
223682832012Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis.5
200789482009[Effect of PIH1D1 on the degradation of its binding protein SNF5].0

Citation

Dessen P

PIH1D1 (PIH1 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71913/pih1d1