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PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)

Identity

Alias_namesphosphoinositide-3-kinase, class 2, alpha polypeptide
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Alias_symbol (synonym)PI3K-C2alpha
Other aliasCPK
PI3-K-C2(ALPHA)
PI3-K-C2A
PI3K-C2-alpha
HGNC (Hugo) PIK3C2A
LocusID (NCBI) 5286
Atlas_Id 41711
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 17086576 and ends at 17207996 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AD_1 () / PIK3C2A (11p15.1)PIK3C2A (11p15.1) / CNN2 (19p13.3)PIK3C2A (11p15.1) / RP11-113D6.6 ()
PIK3C2A (11p15.1) / TEAD1 (11p15.3)PIK3C2A 11p15.1 RP11-113D6.6

Note

Non-annotated gune. Xr%liminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)PIK3C2A   8971
Cards
Entrez_Gene (NCBI)PIK3C2A  5286  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
AliasesCPK; PI3-K-C2(ALPHA); PI3-K-C2A; PI3K-C2-alpha; 
PI3K-C2alpha
GeneCards (Weizmann)PIK3C2A
Ensembl hg19 (Hinxton)ENSG00000011405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011405 [Gene_View]  chr11:17086576-17207996 [Contig_View]  PIK3C2A [Vega]
ICGC DataPortalENSG00000011405
TCGA cBioPortalPIK3C2A
AceView (NCBI)PIK3C2A
Genatlas (Paris)PIK3C2A
WikiGenes5286
SOURCE (Princeton)PIK3C2A
Genetics Home Reference (NIH)PIK3C2A
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3C2A  -     chr11:17086576-17207996 -  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3C2A  -     11p15.1   [Description]    (hg19-Feb_2009)
EnsemblPIK3C2A - 11p15.1 [CytoView hg19]  PIK3C2A - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBIPIK3C2A [Mapview hg19]  PIK3C2A [Mapview hg38]
OMIM603601   
Gene and transcription
Genbank (Entrez)AK294416 AK299474 AK304262 AK309610 AK310248
RefSeq transcript (Entrez)NM_001321378 NM_001321380 NM_002645
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3C2A
Cluster EST : UnigeneHs.736397 [ NCBI ]
CGAP (NCI)Hs.736397
Alternative Splicing GalleryENSG00000011405
Gene ExpressionPIK3C2A [ NCBI-GEO ]   PIK3C2A [ EBI - ARRAY_EXPRESS ]   PIK3C2A [ SEEK ]   PIK3C2A [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3C2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5286
GTEX Portal (Tissue expression)PIK3C2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00443   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00443  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00443
Splice isoforms : SwissVarO00443
Catalytic activity : Enzyme2.7.1.154 [ Enzyme-Expasy ]   2.7.1.1542.7.1.154 [ IntEnz-EBI ]   2.7.1.154 [ BRENDA ]   2.7.1.154 [ KEGG ]   
PhosPhoSitePlusO00443
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_C2 (PS51547)    PI3K_RBD (PS51546)    PIK_HELICAL (PS51545)    PX (PS50195)   
Domains : Interpro (EBI)ARM-type_fold    C2_dom    Kinase-like_dom    Phox    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI3K_C2_dom    PI3K_Ras-bd_dom    PI_Kinase    PInositide-3_kin_accessory_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    PI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3K_rbd (PF00794)    PI3Ka (PF00613)    PX (PF00787)   
Domain families : Pfam (NCBI)pfam00168    pfam00454    pfam00792    pfam00794    pfam00613    pfam00787   
Domain families : Smart (EMBL)C2 (SM00239)  PI3K_C2 (SM00142)  PI3K_rbd (SM00144)  PI3Ka (SM00145)  PI3Kc (SM00146)  PX (SM00312)  
Conserved Domain (NCBI)PIK3C2A
DMDM Disease mutations5286
Blocks (Seattle)PIK3C2A
PDB (SRS)2AR5    2IWL    2REA    2RED   
PDB (PDBSum)2AR5    2IWL    2REA    2RED   
PDB (IMB)2AR5    2IWL    2REA    2RED   
PDB (RSDB)2AR5    2IWL    2REA    2RED   
Structural Biology KnowledgeBase2AR5    2IWL    2REA    2RED   
SCOP (Structural Classification of Proteins)2AR5    2IWL    2REA    2RED   
CATH (Classification of proteins structures)2AR5    2IWL    2REA    2RED   
SuperfamilyO00443
Human Protein AtlasENSG00000011405
Peptide AtlasO00443
HPRD04672
IPIIPI00002580   IPI01011654   IPI00981341   IPI00982877   
Protein Interaction databases
DIP (DOE-UCLA)O00443
IntAct (EBI)O00443
FunCoupENSG00000011405
BioGRIDPIK3C2A
STRING (EMBL)PIK3C2A
ZODIACPIK3C2A
Ontologies - Pathways
QuickGOO00443
Ontology : AmiGOATP binding  nucleus  cytoplasm  Golgi apparatus  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  exocytosis  endocytosis  epidermal growth factor receptor signaling pathway  insulin receptor signaling pathway  vascular smooth muscle contraction  membrane  1-phosphatidylinositol-3-kinase activity  clathrin-coated vesicle  vesicle  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol binding  phosphatidylinositol-3-phosphate biosynthetic process  phosphatidylinositol phosphorylation  platelet-derived growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  clathrin coat assembly  membrane organization  extracellular exosome  
Ontology : EGO-EBIATP binding  nucleus  cytoplasm  Golgi apparatus  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  exocytosis  endocytosis  epidermal growth factor receptor signaling pathway  insulin receptor signaling pathway  vascular smooth muscle contraction  membrane  1-phosphatidylinositol-3-kinase activity  clathrin-coated vesicle  vesicle  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol binding  phosphatidylinositol-3-phosphate biosynthetic process  phosphatidylinositol phosphorylation  platelet-derived growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  clathrin coat assembly  membrane organization  extracellular exosome  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkPIK3C2A
Atlas of Cancer Signalling NetworkPIK3C2A
Wikipedia pathwaysPIK3C2A
Orthology - Evolution
OrthoDB5286
GeneTree (enSembl)ENSG00000011405
Phylogenetic Trees/Animal Genes : TreeFamPIK3C2A
HOVERGENO00443
HOGENOMO00443
Homologs : HomoloGenePIK3C2A
Homology/Alignments : Family Browser (UCSC)PIK3C2A
Gene fusions - Rearrangements
Fusion : MitelmanPIK3C2A/TEAD1 [11p15.1/11p15.3]  
Fusion: TCGAPIK3C2A 11p15.1 RP11-113D6.6 BRCA
Fusion Cancer (Beijing)AD_1 [PIK3C2A]  -  11p15.1 [FUSC000467]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3C2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3C2A
dbVarPIK3C2A
ClinVarPIK3C2A
1000_GenomesPIK3C2A 
Exome Variant ServerPIK3C2A
ExAC (Exome Aggregation Consortium)PIK3C2A (select the gene name)
Genetic variants : HAPMAP5286
Genomic Variants (DGV)PIK3C2A [DGVbeta]
DECIPHERPIK3C2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3C2A 
Mutations
ICGC Data PortalPIK3C2A 
TCGA Data PortalPIK3C2A 
Broad Tumor PortalPIK3C2A
OASIS PortalPIK3C2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3C2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3C2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3C2A
DgiDB (Drug Gene Interaction Database)PIK3C2A
DoCM (Curated mutations)PIK3C2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3C2A (select a term)
intoGenPIK3C2A
Cancer3DPIK3C2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603601   
Orphanet
MedgenPIK3C2A
Genetic Testing Registry PIK3C2A
NextProtO00443 [Medical]
TSGene5286
GENETestsPIK3C2A
Target ValidationPIK3C2A
Huge Navigator PIK3C2A [HugePedia]
snp3D : Map Gene to Disease5286
BioCentury BCIQPIK3C2A
ClinGenPIK3C2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5286
Chemical/Pharm GKB GenePA33304
Clinical trialPIK3C2A
Miscellaneous
canSAR (ICR)PIK3C2A (select the gene name)
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3C2A
EVEXPIK3C2A
GoPubMedPIK3C2A
iHOPPIK3C2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:24:49 CEST 2017

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