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PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta)

Identity

Alias_namesphosphoinositide-3-kinase, class 2, beta polypeptide
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Alias_symbol (synonym)C2-PI3K
PI3K-C2beta
Other alias
HGNC (Hugo) PIK3C2B
LocusID (NCBI) 5287
Atlas_Id 41712
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 204422630 and ends at 204490346 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PIK3C2B (1q32.1) / ANKHD1 (5q31.3)PIK3C2B (1q32.1) / DSTYK (1q32.1)PLEKHA6 (1q32.1) / PIK3C2B (1q32.1)
SATB2 (2q33.1) / PIK3C2B (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3C2B   8972
Cards
Entrez_Gene (NCBI)PIK3C2B  5287  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
AliasesC2-PI3K
GeneCards (Weizmann)PIK3C2B
Ensembl hg19 (Hinxton)ENSG00000133056 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133056 [Gene_View]  chr1:204422630-204490346 [Contig_View]  PIK3C2B [Vega]
ICGC DataPortalENSG00000133056
TCGA cBioPortalPIK3C2B
AceView (NCBI)PIK3C2B
Genatlas (Paris)PIK3C2B
WikiGenes5287
SOURCE (Princeton)PIK3C2B
Genetics Home Reference (NIH)PIK3C2B
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3C2B  -     chr1:204422630-204490346 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3C2B  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblPIK3C2B - 1q32.1 [CytoView hg19]  PIK3C2B - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIPIK3C2B [Mapview hg19]  PIK3C2B [Mapview hg38]
OMIM602838   
Gene and transcription
Genbank (Entrez)AB210006 AK308153 BC094741 BC132876 BC136645
RefSeq transcript (Entrez)NM_002646
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3C2B
Cluster EST : UnigeneHs.497487 [ NCBI ]
CGAP (NCI)Hs.497487
Alternative Splicing GalleryENSG00000133056
Gene ExpressionPIK3C2B [ NCBI-GEO ]   PIK3C2B [ EBI - ARRAY_EXPRESS ]   PIK3C2B [ SEEK ]   PIK3C2B [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3C2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5287
GTEX Portal (Tissue expression)PIK3C2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00750
Splice isoforms : SwissVarO00750
Catalytic activity : Enzyme2.7.1.154 [ Enzyme-Expasy ]   2.7.1.1542.7.1.154 [ IntEnz-EBI ]   2.7.1.154 [ BRENDA ]   2.7.1.154 [ KEGG ]   
PhosPhoSitePlusO00750
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_C2 (PS51547)    PI3K_RBD (PS51546)    PIK_HELICAL (PS51545)    PX (PS50195)   
Domains : Interpro (EBI)ARM-type_fold    C2_dom    Kinase-like_dom    Phox    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI3K_C2_dom    PI3K_Ras-bd_dom    PI_Kinase    PInositide-3_kin_accessory_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    PI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3K_rbd (PF00794)    PI3Ka (PF00613)    PX (PF00787)   
Domain families : Pfam (NCBI)pfam00168    pfam00454    pfam00792    pfam00794    pfam00613    pfam00787   
Domain families : Smart (EMBL)C2 (SM00239)  PI3K_C2 (SM00142)  PI3K_rbd (SM00144)  PI3Ka (SM00145)  PI3Kc (SM00146)  PX (SM00312)  
Conserved Domain (NCBI)PIK3C2B
DMDM Disease mutations5287
Blocks (Seattle)PIK3C2B
SuperfamilyO00750
Human Protein AtlasENSG00000133056
Peptide AtlasO00750
HPRD04160
IPIIPI00292056   IPI00844313   IPI00647314   IPI00646074   IPI00514737   
Protein Interaction databases
DIP (DOE-UCLA)O00750
IntAct (EBI)O00750
FunCoupENSG00000133056
BioGRIDPIK3C2B
STRING (EMBL)PIK3C2B
ZODIACPIK3C2B
Ontologies - Pathways
QuickGOO00750
Ontology : AmiGOlipid kinase activity  protein binding  ATP binding  nucleoplasm  endoplasmic reticulum  cytosol  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  biological_process  cellular response to starvation  1-phosphatidylinositol-3-kinase activity  endocytic vesicle  1-phosphatidylinositol-4-phosphate 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol binding  phosphatidylinositol-3-phosphate biosynthetic process  protein kinase B signaling  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  autophagosome organization  
Ontology : EGO-EBIlipid kinase activity  protein binding  ATP binding  nucleoplasm  endoplasmic reticulum  cytosol  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  biological_process  cellular response to starvation  1-phosphatidylinositol-3-kinase activity  endocytic vesicle  1-phosphatidylinositol-4-phosphate 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol binding  phosphatidylinositol-3-phosphate biosynthetic process  protein kinase B signaling  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  autophagosome organization  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkPIK3C2B
Atlas of Cancer Signalling NetworkPIK3C2B
Wikipedia pathwaysPIK3C2B
Orthology - Evolution
OrthoDB5287
GeneTree (enSembl)ENSG00000133056
Phylogenetic Trees/Animal Genes : TreeFamPIK3C2B
HOVERGENO00750
HOGENOMO00750
Homologs : HomoloGenePIK3C2B
Homology/Alignments : Family Browser (UCSC)PIK3C2B
Gene fusions - Rearrangements
Fusion : MitelmanPIK3C2B/DSTYK [1q32.1/1q32.1]  
Fusion : MitelmanPLEKHA6/PIK3C2B [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3C2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3C2B
dbVarPIK3C2B
ClinVarPIK3C2B
1000_GenomesPIK3C2B 
Exome Variant ServerPIK3C2B
ExAC (Exome Aggregation Consortium)PIK3C2B (select the gene name)
Genetic variants : HAPMAP5287
Genomic Variants (DGV)PIK3C2B [DGVbeta]
DECIPHERPIK3C2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3C2B 
Mutations
ICGC Data PortalPIK3C2B 
TCGA Data PortalPIK3C2B 
Broad Tumor PortalPIK3C2B
OASIS PortalPIK3C2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3C2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3C2B
intOGen PortalPIK3C2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3C2B
DgiDB (Drug Gene Interaction Database)PIK3C2B
DoCM (Curated mutations)PIK3C2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3C2B (select a term)
intoGenPIK3C2B
Cancer3DPIK3C2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602838   
Orphanet
MedgenPIK3C2B
Genetic Testing Registry PIK3C2B
NextProtO00750 [Medical]
TSGene5287
GENETestsPIK3C2B
Target ValidationPIK3C2B
Huge Navigator PIK3C2B [HugePedia]
snp3D : Map Gene to Disease5287
BioCentury BCIQPIK3C2B
ClinGenPIK3C2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5287
Chemical/Pharm GKB GenePA33305
Clinical trialPIK3C2B
Miscellaneous
canSAR (ICR)PIK3C2B (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3C2B
EVEXPIK3C2B
GoPubMedPIK3C2B
iHOPPIK3C2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:49:29 CEST 2017

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