PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta)

2003-06-01 Affiliation

Identity

HGNC

PIK3C2B

LOCATION

1q32.1

LOCUSID

5287

ALIAS

C2-PI3K

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5287
MIM: 602838
HGNC: 8972
Ensembl: ENSG00000133056

Variants:

dbSNP: 5287
ClinVar: 5287
TCGA: ENSG00000133056
COSMIC: PIK3C2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133056	ENST00000367184	Q5SWA0
ENSG00000133056	ENST00000367187	O00750
ENSG00000133056	ENST00000367187	A2RUF7
ENSG00000133056	ENST00000415899	Q5SW98
ENSG00000133056	ENST00000424712	F5GWN5
ENSG00000133056	ENST00000429009	Q5SW97

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
Phosphatidylinositol signaling system	KEGG	ko04070
Inositol phosphate metabolism	KEGG	hsa00562
Phosphatidylinositol signaling system	KEGG	hsa04070
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the plasma membrane	REACTOME	R-HSA-1660499

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134941638	FGFR1OP	Gene	Pathway	associated	20124951
PA134972108	FGFR1OP2	Gene	Pathway	associated	20124951
PA24684	AKT1	Gene	Pathway	associated	20124951, 28362716
PA24685	AKT2	Gene	Pathway	associated	20124951
PA24686	AKT3	Gene	Pathway	associated	20124951
PA28127	FGFR1	Gene	Pathway	associated	20124951
PA28128	FGFR2	Gene	Pathway	associated	20124951
PA28129	FGFR3	Gene	Pathway	associated	20124951
PA28130	FGFR4	Gene	Pathway	associated	20124951
PA28131	FGFR3P1	Gene	Pathway	associated	20124951
PA28132	FGFRL1	Gene	Pathway	associated	20124951
PA28180	FLT1	Gene	Pathway	associated	28362716
PA28183	FLT4	Gene	Pathway	associated	28362716
PA29457	HRH2	Gene	Pathway	associated
PA30086	KDR	Gene	Pathway	associated	28362716

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19536175	2009	Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.	30
16775008	2006	Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.	28
19587117	2009	The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.	26
12356726	2002	Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.	25
16314532	2005	The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation.	24
16113997	2005	The class II phosphoinositide 3-kinase PI3K-C2beta regulates cell migration by a PtdIns3P dependent mechanism.	23
22128329	2011	Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.	19
20197460	2010	Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.	16

Citation

Dessen P

PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41712/pik3c2b