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PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)

Identity

Alias_namesphosphoinositide-3-kinase, class 2, gamma polypeptide
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Other aliasPI3K-C2-gamma
PI3K-C2GAMMA
HGNC (Hugo) PIK3C2G
LocusID (NCBI) 5288
Atlas_Id 41713
Location 12p12.3  [Link to chromosome band 12p12]
Location_base_pair Starts at 18261540 and ends at 18648418 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EFNA3 (1q22) / PIK3C2G (12p12.3)ERC1 (12p13.33) / PIK3C2G (12p12.3)PIK3C2G (12p12.3) / PPFIBP1 (12p11.23)
PIK3C2G (12p12.3) / SAE1 (19q13.32)RP11-540D14.8 () / PIK3C2G (12p12.3)ERC1 12p13.33 / PIK3C2G 12p12.3
PIK3C2G 12p12.3 / PPFIBP1 12p11.23RP11-540D14.8 PIK3C2G 12p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3C2G   8973
Cards
Entrez_Gene (NCBI)PIK3C2G  5288  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
AliasesPI3K-C2-gamma; PI3K-C2GAMMA
GeneCards (Weizmann)PIK3C2G
Ensembl hg19 (Hinxton)ENSG00000139144 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139144 [Gene_View]  chr12:18261540-18648418 [Contig_View]  PIK3C2G [Vega]
ICGC DataPortalENSG00000139144
TCGA cBioPortalPIK3C2G
AceView (NCBI)PIK3C2G
Genatlas (Paris)PIK3C2G
WikiGenes5288
SOURCE (Princeton)PIK3C2G
Genetics Home Reference (NIH)PIK3C2G
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3C2G  -     chr12:18261540-18648418 +  12p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3C2G  -     12p12.3   [Description]    (hg19-Feb_2009)
EnsemblPIK3C2G - 12p12.3 [CytoView hg19]  PIK3C2G - 12p12.3 [CytoView hg38]
Mapping of homologs : NCBIPIK3C2G [Mapview hg19]  PIK3C2G [Mapview hg38]
OMIM609001   
Gene and transcription
Genbank (Entrez)AI478164 AJ000008 BC130277 BC144133 BC144134
RefSeq transcript (Entrez)NM_001288772 NM_001288774 NM_004570
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3C2G
Cluster EST : UnigeneHs.22500 [ NCBI ]
CGAP (NCI)Hs.22500
Alternative Splicing GalleryENSG00000139144
Gene ExpressionPIK3C2G [ NCBI-GEO ]   PIK3C2G [ EBI - ARRAY_EXPRESS ]   PIK3C2G [ SEEK ]   PIK3C2G [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3C2G [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5288
GTEX Portal (Tissue expression)PIK3C2G
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75747   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75747  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75747
Splice isoforms : SwissVarO75747
Catalytic activity : Enzyme2.7.1.154 [ Enzyme-Expasy ]   2.7.1.1542.7.1.154 [ IntEnz-EBI ]   2.7.1.154 [ BRENDA ]   2.7.1.154 [ KEGG ]   
PhosPhoSitePlusO75747
Domaine pattern : Prosite (Expaxy)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_C2 (PS51547)    PI3K_RBD (PS51546)    PIK_HELICAL (PS51545)    PX (PS50195)   
Domains : Interpro (EBI)ARM-type_fold    C2_dom    Kinase-like_dom    Phox    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI3K_C2_dom    PI3K_Ras-bd_dom    PI_Kinase    PInositide-3_kin_accessory_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    PI3_PI4_kinase (PF00454)    PI3K_rbd (PF00794)    PI3Ka (PF00613)    PX (PF00787)   
Domain families : Pfam (NCBI)pfam00168    pfam00454    pfam00794    pfam00613    pfam00787   
Domain families : Smart (EMBL)C2 (SM00239)  PI3Ka (SM00145)  PI3Kc (SM00146)  PX (SM00312)  
Conserved Domain (NCBI)PIK3C2G
DMDM Disease mutations5288
Blocks (Seattle)PIK3C2G
PDB (SRS)2WWE   
PDB (PDBSum)2WWE   
PDB (IMB)2WWE   
PDB (RSDB)2WWE   
Structural Biology KnowledgeBase2WWE   
SCOP (Structural Classification of Proteins)2WWE   
CATH (Classification of proteins structures)2WWE   
SuperfamilyO75747
Human Protein AtlasENSG00000139144
Peptide AtlasO75747
HPRD16416
IPIIPI01015248   IPI00922656   IPI01012284   
Protein Interaction databases
DIP (DOE-UCLA)O75747
IntAct (EBI)O75747
FunCoupENSG00000139144
BioGRIDPIK3C2G
STRING (EMBL)PIK3C2G
ZODIACPIK3C2G
Ontologies - Pathways
QuickGOO75747
Ontology : AmiGOATP binding  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  chemotaxis  biological_process  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  phosphatidylinositol phosphate kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol binding  phosphatidylinositol-3-phosphate biosynthetic process  viral RNA genome replication  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  
Ontology : EGO-EBIATP binding  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  chemotaxis  biological_process  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  phosphatidylinositol phosphate kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol binding  phosphatidylinositol-3-phosphate biosynthetic process  viral RNA genome replication  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  
Pathways : BIOCARTAfMLP induced chemokine gene expression in HMC-1 cells [Genes]    CCR3 signaling in Eosinophils [Genes]    CXCR4 Signaling Pathway [Genes]   
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
NDEx NetworkPIK3C2G
Atlas of Cancer Signalling NetworkPIK3C2G
Wikipedia pathwaysPIK3C2G
Orthology - Evolution
OrthoDB5288
GeneTree (enSembl)ENSG00000139144
Phylogenetic Trees/Animal Genes : TreeFamPIK3C2G
HOVERGENO75747
HOGENOMO75747
Homologs : HomoloGenePIK3C2G
Homology/Alignments : Family Browser (UCSC)PIK3C2G
Gene fusions - Rearrangements
Fusion : MitelmanERC1/PIK3C2G [12p13.33/12p12.3]  [t(12;12)(p12;p13)]  
Fusion : MitelmanPIK3C2G/PPFIBP1 [12p12.3/12p11.23]  [t(12;12)(p11;p12)]  
Fusion: TCGAERC1 12p13.33 PIK3C2G 12p12.3 BRCA
Fusion: TCGAPIK3C2G 12p12.3 PPFIBP1 12p11.23 BRCA
Fusion: TCGARP11-540D14.8 PIK3C2G 12p12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3C2G [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3C2G
dbVarPIK3C2G
ClinVarPIK3C2G
1000_GenomesPIK3C2G 
Exome Variant ServerPIK3C2G
ExAC (Exome Aggregation Consortium)PIK3C2G (select the gene name)
Genetic variants : HAPMAP5288
Genomic Variants (DGV)PIK3C2G [DGVbeta]
DECIPHERPIK3C2G [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3C2G 
Mutations
ICGC Data PortalPIK3C2G 
TCGA Data PortalPIK3C2G 
Broad Tumor PortalPIK3C2G
OASIS PortalPIK3C2G [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3C2G  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3C2G
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3C2G
DgiDB (Drug Gene Interaction Database)PIK3C2G
DoCM (Curated mutations)PIK3C2G (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3C2G (select a term)
intoGenPIK3C2G
Cancer3DPIK3C2G(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609001   
Orphanet
MedgenPIK3C2G
Genetic Testing Registry PIK3C2G
NextProtO75747 [Medical]
TSGene5288
GENETestsPIK3C2G
Target ValidationPIK3C2G
Huge Navigator PIK3C2G [HugePedia]
snp3D : Map Gene to Disease5288
BioCentury BCIQPIK3C2G
ClinGenPIK3C2G
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5288
Chemical/Pharm GKB GenePA33306
Clinical trialPIK3C2G
Miscellaneous
canSAR (ICR)PIK3C2G (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3C2G
EVEXPIK3C2G
GoPubMedPIK3C2G
iHOPPIK3C2G
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:49:29 CEST 2017

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