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PIK3C3 (phosphoinositide-3-kinase, class 3)

Identity

Other namesMGC61518
Vps34
HGNC (Hugo) PIK3C3
Location 18q12.3
Location_base_pair Starts at 37789197 and ends at 37915444 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PIK3C3   8974
Entrez_Gene (NCBI)PIK3C3  5289  phosphoinositide-3-kinase, class 3
Cards
GeneCards (Weizmann)PIK3C3
Ensembl (Hinxton)ENSG00000078142 [Gene_View]  PIK3C3 [Vega]
AceView (NCBI)PIK3C3
Genatlas (Paris)PIK3C3
euGene (Indiana)5289
SOURCE (Stanford)NM_002647
Genomic and cartography
GoldenPath (UCSC)PIK3C3  -  18q12.3   chr18:37789197-37915444 +  18q12.3   [Description]    (hg18-March_2006)
EnsemblPIK3C3 - 18q12.3 [CytoView]
Mapping of homologs : NCBIPIK3C3 [Mapview]
OMIM602609   
Gene and transcription
Gene : Genbank (Entrez)AK022653 AK090567 AK298517 AK308364 BC010388
Reference sequence (RefSeq transcript) :SRSNM_002647
Reference transcript : EntrezNM_002647
RefSeq genomic : SRSAC_000061 AC_000150 NC_000018 NT_010966 NW_001838467 NW_927095
RefSeq genomic : EntrezAC_000061 AC_000150 NC_000018 NT_010966 NW_001838467 NW_927095
Consensus coding sequences : CCDS NCBIPIK3C3
Cluster EST : UnigeneHs.464971 [ SRS ] Hs.464971 [ NCBI ]
Alternative Splicing : Fast-db (Paris)3903
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ8NEB9 (SRS) Q8NEB9 (Expasy) Q8NEB9 (Uniprot)
With graphics : InterProQ8NEB9
Splice isoforms : VarSplice FASTAQ8NEB9(VarSplice FASTA)
Domaine pattern : Prosite (SRS)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)   
Domain pattern : Prosite (Expaxy)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)   
Domains : Interpro (SRS)C2_Ca-dep    PI3/4_kinase_cat    PI3K_C2    PI3K_Vps34    PI3Ka    PI_Kinase   
Domains : Interpro (EBI)C2_Ca-dep    PI3/4_kinase_cat    PI3K_C2    PI3K_Vps34    PI3Ka    PI_Kinase   
Related proteins : CluSTrQ8NEB9
Domain families : Pfam SRSPI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3Ka (PF00613)   
Domain families : Pfam SangerPI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3Ka (PF00613)   
Domain families : Pfam NCBIpfam00454    pfam00792    pfam00613   
Domain families : Smart EMBLC2 (SM00239)PI3K_C2 (SM00142)PI3Ka (SM00145)PI3Kc (SM00146)
Blocks (Seattle)Q8NEB9
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD04009
Protein Interaction databases
DIP (DOE-UCLA)Q8NEB9
IntAct (EBI)Q8NEB9
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIPIK3C3
SNP : GeneSNP UtahPIK3C3
SNP : HGBasePIK3C3
Genetic variants : HAPMAPPIK3C3
Somatic Mutations in Cancer : COSMICPIK3C3 
Mutations and Diseases : HGMDPIK3C3
Hereditary diseases : OMIM602609   
Hereditary diseases : GENETests602609   
Diseases : Genetic AssociationPIK3C3
General knowledge
Homologs : HomoloGenePIK3C3
Homology/Alignments : Family Browser UCSCPIK3C3
Phylogenetic Trees/Animal Genes : TreeFamPIK3C3
Catalytic activity : Enzyme2.7.1.137 [ Enzyme-Expasy ]   2.7.1.137 [ Enzyme-SRS ]   2.7.1.137 [ IntEnz-EBI ]   2.7.1.137 [ BRENDA ]   2.7.1.137 [ KEGG ]   
Chemical/Protein Interactions : CTD5289
Keywords Ontology : AmiGOnucleotide binding  inositol or phosphatidylinositol kinase activity  protein kinase activity  protein binding  ATP binding  cytosol  phosphoinositide 3-kinase complex  protein amino acid phosphorylation  1-phosphatidylinositol-3-kinase activity  transferase activity  manganese ion binding  phosphoinositide phosphorylation  phosphoinositide-mediated signaling  
Keywords Ontology : EGO-EBInucleotide binding  inositol or phosphatidylinositol kinase activity  protein kinase activity  protein binding  ATP binding  cytosol  phosphoinositide 3-kinase complex  protein amino acid phosphorylation  1-phosphatidylinositol-3-kinase activity  transferase activity  manganese ion binding  phosphoinositide phosphorylation  phosphoinositide-mediated signaling  
Pathways : BIOCARTA
Pathways : KEGGInositol phosphate metabolismPhosphatidylinositol signaling systemRegulation of autophagy
Other databases
Probes
Probes : ImagenesPIK3C3 Related clones (RZPD - Berlin)
Literature
PubMed41 Pubmed reference(s) in Entrez
PubGenePIK3C3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 16:33:26 CEST 2009
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