Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)

Identity

Alias_namesphosphoinositide-3-kinase, class 3
phosphatidylinositol 3-kinase, catalytic subunit type 3
Alias_symbol (synonym)Vps34
Other aliasVPS34
hVps34
HGNC (Hugo) PIK3C3
LocusID (NCBI) 5289
Atlas_Id 41714
Location 18q12.3  [Link to chromosome band 18q12]
Location_base_pair Starts at 39535163 and ends at 39661446 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PIK3C3 (18q12.3) / DAB2 (5p13.1)PIK3C3 (18q12.3) / LOC100132273 ()PIK3C3 (18q12.3) / TRPC6 (11q22.1)
TWSG1 (18p11.22) / PIK3C3 (18q12.3)PIK3C3 18q12.3 / TRPC6 11q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PIK3C3   8974
Cards
Entrez_Gene (NCBI)PIK3C3  5289  phosphatidylinositol 3-kinase catalytic subunit type 3
AliasesVPS34; Vps34; hVps34
GeneCards (Weizmann)PIK3C3
Ensembl hg19 (Hinxton)ENSG00000078142 [Gene_View]  chr18:39535163-39661446 [Contig_View]  PIK3C3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000078142 [Gene_View]  chr18:39535163-39661446 [Contig_View]  PIK3C3 [Vega]
ICGC DataPortalENSG00000078142
TCGA cBioPortalPIK3C3
AceView (NCBI)PIK3C3
Genatlas (Paris)PIK3C3
WikiGenes5289
SOURCE (Princeton)PIK3C3
Genetics Home Reference (NIH)PIK3C3
Genomic and cartography
GoldenPath hg19 (UCSC)PIK3C3  -     chr18:39535163-39661446 +  18q12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PIK3C3  -     18q12.3   [Description]    (hg38-Dec_2013)
EnsemblPIK3C3 - 18q12.3 [CytoView hg19]  PIK3C3 - 18q12.3 [CytoView hg38]
Mapping of homologs : NCBIPIK3C3 [Mapview hg19]  PIK3C3 [Mapview hg38]
OMIM602609   
Gene and transcription
Genbank (Entrez)AF131843 AK022653 AK090567 AK298517 AK308364
RefSeq transcript (Entrez)NM_001308020 NM_002647
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010966 NW_004929410
Consensus coding sequences : CCDS (NCBI)PIK3C3
Cluster EST : UnigeneHs.656958 [ NCBI ]
CGAP (NCI)Hs.656958
Alternative Splicing GalleryENSG00000078142
Gene ExpressionPIK3C3 [ NCBI-GEO ]   PIK3C3 [ EBI - ARRAY_EXPRESS ]   PIK3C3 [ SEEK ]   PIK3C3 [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3C3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5289
GTEX Portal (Tissue expression)PIK3C3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NEB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NEB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NEB9
Splice isoforms : SwissVarQ8NEB9
Catalytic activity : Enzyme2.7.1.137 [ Enzyme-Expasy ]   2.7.1.1372.7.1.137 [ IntEnz-EBI ]   2.7.1.137 [ BRENDA ]   2.7.1.137 [ KEGG ]   
PhosPhoSitePlusQ8NEB9
Domaine pattern : Prosite (Expaxy)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_C2 (PS51547)    PIK_HELICAL (PS51545)   
Domains : Interpro (EBI)ARM-type_fold    C2_dom    Kinase-like_dom    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI3K_C2_dom    PI3K_Vps34    PI_Kinase    PInositide-3_kin_accessory_dom   
Domain families : Pfam (Sanger)PI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3Ka (PF00613)   
Domain families : Pfam (NCBI)pfam00454    pfam00792    pfam00613   
Domain families : Smart (EMBL)C2 (SM00239)  PI3K_C2 (SM00142)  PI3Ka (SM00145)  PI3Kc (SM00146)  
Conserved Domain (NCBI)PIK3C3
DMDM Disease mutations5289
Blocks (Seattle)PIK3C3
PDB (SRS)3IHY    3LS8    4OYS    4PH4    4UWF    4UWG    4UWH    4UWK    4UWL   
PDB (PDBSum)3IHY    3LS8    4OYS    4PH4    4UWF    4UWG    4UWH    4UWK    4UWL   
PDB (IMB)3IHY    3LS8    4OYS    4PH4    4UWF    4UWG    4UWH    4UWK    4UWL   
PDB (RSDB)3IHY    3LS8    4OYS    4PH4    4UWF    4UWG    4UWH    4UWK    4UWL   
Structural Biology KnowledgeBase3IHY    3LS8    4OYS    4PH4    4UWF    4UWG    4UWH    4UWK    4UWL   
SCOP (Structural Classification of Proteins)3IHY    3LS8    4OYS    4PH4    4UWF    4UWG    4UWH    4UWK    4UWL   
CATH (Classification of proteins structures)3IHY    3LS8    4OYS    4PH4    4UWF    4UWG    4UWH    4UWK    4UWL   
SuperfamilyQ8NEB9
Human Protein AtlasENSG00000078142
Peptide AtlasQ8NEB9
HPRD04009
IPIIPI00299755   IPI00873758   
Protein Interaction databases
DIP (DOE-UCLA)Q8NEB9
IntAct (EBI)Q8NEB9
FunCoupENSG00000078142
BioGRIDPIK3C3
STRING (EMBL)PIK3C3
ZODIACPIK3C3
Ontologies - Pathways
QuickGOQ8NEB9
Ontology : AmiGOautophagosome assembly  cytokinesis  protein kinase activity  protein binding  ATP binding  late endosome  autophagosome  cytosol  axoneme  phosphatidylinositol 3-kinase complex  protein phosphorylation  phosphatidylinositol biosynthetic process  endosome organization  membrane  macroautophagy  macroautophagy  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  protein processing  midbody  phagocytic vesicle membrane  regulation of cytokinesis  toll-like receptor 9 signaling pathway  phosphatidylinositol 3-kinase complex, class III  phosphatidylinositol-3-phosphate biosynthetic process  cellular response to glucose starvation  response to leucine  early endosome to late endosome transport  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  regulation of protein secretion  
Ontology : EGO-EBIautophagosome assembly  cytokinesis  protein kinase activity  protein binding  ATP binding  late endosome  autophagosome  cytosol  axoneme  phosphatidylinositol 3-kinase complex  protein phosphorylation  phosphatidylinositol biosynthetic process  endosome organization  membrane  macroautophagy  macroautophagy  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  protein processing  midbody  phagocytic vesicle membrane  regulation of cytokinesis  toll-like receptor 9 signaling pathway  phosphatidylinositol 3-kinase complex, class III  phosphatidylinositol-3-phosphate biosynthetic process  cellular response to glucose starvation  response to leucine  early endosome to late endosome transport  phosphatidylinositol phosphorylation  phosphatidylinositol-mediated signaling  regulation of protein secretion  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    Regulation of autophagy    Phagosome    Tuberculosis   
NDEx NetworkPIK3C3
Atlas of Cancer Signalling NetworkPIK3C3
Wikipedia pathwaysPIK3C3
Orthology - Evolution
OrthoDB5289
GeneTree (enSembl)ENSG00000078142
Phylogenetic Trees/Animal Genes : TreeFamPIK3C3
HOVERGENQ8NEB9
HOGENOMQ8NEB9
Homologs : HomoloGenePIK3C3
Homology/Alignments : Family Browser (UCSC)PIK3C3
Gene fusions - Rearrangements
Fusion : MitelmanPIK3C3/TRPC6 [18q12.3/11q22.1]  
Fusion : MitelmanTWSG1/PIK3C3 [18p11.22/18q12.3]  [t(18;18)(p11;q12)]  
Fusion: TCGAPIK3C3 18q12.3 TRPC6 11q22.1 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3C3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3C3
dbVarPIK3C3
ClinVarPIK3C3
1000_GenomesPIK3C3 
Exome Variant ServerPIK3C3
ExAC (Exome Aggregation Consortium)PIK3C3 (select the gene name)
Genetic variants : HAPMAP5289
Genomic Variants (DGV)PIK3C3 [DGVbeta]
DECIPHER (Syndromes)18:39535163-39661446  ENSG00000078142
CONAN: Copy Number AnalysisPIK3C3 
Mutations
ICGC Data PortalPIK3C3 
TCGA Data PortalPIK3C3 
Broad Tumor PortalPIK3C3
OASIS PortalPIK3C3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3C3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3C3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3C3
DgiDB (Drug Gene Interaction Database)PIK3C3
DoCM (Curated mutations)PIK3C3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3C3 (select a term)
intoGenPIK3C3
Cancer3DPIK3C3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602609   
Orphanet
MedgenPIK3C3
Genetic Testing Registry PIK3C3
NextProtQ8NEB9 [Medical]
TSGene5289
GENETestsPIK3C3
Huge Navigator PIK3C3 [HugePedia]
snp3D : Map Gene to Disease5289
BioCentury BCIQPIK3C3
ClinGenPIK3C3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5289
Chemical/Pharm GKB GenePA33307
Clinical trialPIK3C3
Miscellaneous
canSAR (ICR)PIK3C3 (select the gene name)
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3C3
EVEXPIK3C3
GoPubMedPIK3C3
iHOPPIK3C3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:21:25 CET 2017

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