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PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)

Identity

Alias_namesPIK3C1
phosphoinositide-3-kinase, catalytic, beta polypeptide
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Other aliasP110BETA
PI3K
PI3KBETA
HGNC (Hugo) PIK3CB
LocusID (NCBI) 5291
Atlas_Id 41715
Location 3q22.3  [Link to chromosome band 3q22]
Location_base_pair Starts at 138652698 and ends at 138707621 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP70 (3q22.3) / PIK3CB (3q22.3)PIK3CB (3q22.3) / BFSP2 (3q22.1)PIK3CB (3q22.3) / COPB2 (3q23)
PIK3CB (3q22.3) / KCNAB1 (3q25.31)PIK3CB (3q22.3) / NVL (1q42.11)PIK3CB (3q22.3) / PCCB (3q22.3)
PIK3CB (3q22.3) / TSPO (22q13.2)PIK3CB 3q22.3 / BFSP2 3q22.1PIK3CB 3q22.3 / COPB2 3q23
PIK3CB 3q22.3 / KCNAB1 3q25.31PIK3CB 3q22.3 / PCCB 3q22.3PIK3CB 3q22.3 / TSPO 22q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PIK3CB   8976
Cards
Entrez_Gene (NCBI)PIK3CB  5291  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
AliasesP110BETA; PI3K; PI3KBETA; PIK3C1
GeneCards (Weizmann)PIK3CB
Ensembl hg19 (Hinxton)ENSG00000051382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000051382 [Gene_View]  chr3:138652698-138707621 [Contig_View]  PIK3CB [Vega]
ICGC DataPortalENSG00000051382
TCGA cBioPortalPIK3CB
AceView (NCBI)PIK3CB
Genatlas (Paris)PIK3CB
WikiGenes5291
SOURCE (Princeton)PIK3CB
Genetics Home Reference (NIH)PIK3CB
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3CB  -     chr3:138652698-138707621 -  3q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3CB  -     3q22.3   [Description]    (hg19-Feb_2009)
EnsemblPIK3CB - 3q22.3 [CytoView hg19]  PIK3CB - 3q22.3 [CytoView hg38]
Mapping of homologs : NCBIPIK3CB [Mapview hg19]  PIK3CB [Mapview hg38]
OMIM602925   
Gene and transcription
Genbank (Entrez)AI623206 AK293754 AK302937 BC003393 BC022049
RefSeq transcript (Entrez)NM_001256045 NM_006219
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3CB
Cluster EST : UnigeneHs.239818 [ NCBI ]
CGAP (NCI)Hs.239818
Alternative Splicing GalleryENSG00000051382
Gene ExpressionPIK3CB [ NCBI-GEO ]   PIK3CB [ EBI - ARRAY_EXPRESS ]   PIK3CB [ SEEK ]   PIK3CB [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3CB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5291
GTEX Portal (Tissue expression)PIK3CB
Human Protein AtlasENSG00000051382-PIK3CB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42338   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42338  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42338
Splice isoforms : SwissVarP42338
Catalytic activity : Enzyme2.7.1.153 [ Enzyme-Expasy ]   2.7.1.1532.7.1.153 [ IntEnz-EBI ]   2.7.1.153 [ BRENDA ]   2.7.1.153 [ KEGG ]   
PhosPhoSitePlusP42338
Domaine pattern : Prosite (Expaxy)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_ABD (PS51544)    PI3K_C2 (PS51547)    PI3K_RBD (PS51546)    PIK_HELICAL (PS51545)   
Domains : Interpro (EBI)ARM-type_fold    C2_dom    Kinase-like_dom    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI3K_adapt-bd_dom    PI3K_C2_dom    PI3K_Ras-bd_dom    PI_Kinase    PInositide-3_kin_accessory_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)PI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3K_p85B (PF02192)    PI3K_rbd (PF00794)    PI3Ka (PF00613)   
Domain families : Pfam (NCBI)pfam00454    pfam00792    pfam02192    pfam00794    pfam00613   
Domain families : Smart (EMBL)PI3K_C2 (SM00142)  PI3K_p85B (SM00143)  PI3K_rbd (SM00144)  PI3Ka (SM00145)  PI3Kc (SM00146)  
Conserved Domain (NCBI)PIK3CB
DMDM Disease mutations5291
Blocks (Seattle)PIK3CB
SuperfamilyP42338
Human Protein Atlas [tissue]ENSG00000051382-PIK3CB [tissue]
Peptide AtlasP42338
HPRD04234
IPIIPI00031388   IPI00797179   IPI00946617   IPI00946458   IPI00946966   IPI00946800   IPI00945232   IPI00947096   IPI00947249   
Protein Interaction databases
DIP (DOE-UCLA)P42338
IntAct (EBI)P42338
FunCoupENSG00000051382
BioGRIDPIK3CB
STRING (EMBL)PIK3CB
ZODIACPIK3CB
Ontologies - Pathways
QuickGOP42338
Ontology : AmiGOactivation of MAPK activity  endothelial cell proliferation  regulation of cell-matrix adhesion  protein binding  ATP binding  nucleus  nucleolus  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  cellular calcium ion homeostasis  autophagy  chemotaxis  homophilic cell adhesion via plasma membrane adhesion molecules  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  G-protein coupled receptor signaling pathway  axon guidance  positive regulation of autophagy  positive regulation of gene expression  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  regulation of phosphatidylinositol 3-kinase signaling  kinase activity  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  phosphorylation  cell migration  platelet activation  midbody  positive regulation of neutrophil apoptotic process  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol-3-phosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  embryonic cleavage  insulin receptor substrate binding  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  vascular endothelial growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  T cell receptor signaling pathway  leukocyte migration  angiogenesis involved in wound healing  platelet aggregation  regulation of clathrin-dependent endocytosis  
Ontology : EGO-EBIactivation of MAPK activity  endothelial cell proliferation  regulation of cell-matrix adhesion  protein binding  ATP binding  nucleus  nucleolus  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  cellular calcium ion homeostasis  autophagy  chemotaxis  homophilic cell adhesion via plasma membrane adhesion molecules  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  G-protein coupled receptor signaling pathway  axon guidance  positive regulation of autophagy  positive regulation of gene expression  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  regulation of phosphatidylinositol 3-kinase signaling  kinase activity  1-phosphatidylinositol-3-kinase activity  1-phosphatidylinositol-3-kinase activity  phosphorylation  cell migration  platelet activation  midbody  positive regulation of neutrophil apoptotic process  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  phosphatidylinositol-3-phosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  embryonic cleavage  insulin receptor substrate binding  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  vascular endothelial growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  T cell receptor signaling pathway  leukocyte migration  angiogenesis involved in wound healing  platelet aggregation  regulation of clathrin-dependent endocytosis  
Pathways : KEGG   
NDEx NetworkPIK3CB
Atlas of Cancer Signalling NetworkPIK3CB
Wikipedia pathwaysPIK3CB
Orthology - Evolution
OrthoDB5291
GeneTree (enSembl)ENSG00000051382
Phylogenetic Trees/Animal Genes : TreeFamPIK3CB
HOVERGENP42338
HOGENOMP42338
Homologs : HomoloGenePIK3CB
Homology/Alignments : Family Browser (UCSC)PIK3CB
Gene fusions - Rearrangements
Fusion : MitelmanPIK3CB/BFSP2 [3q22.3/3q22.1]  
Fusion : MitelmanPIK3CB/COPB2 [3q22.3/3q23]  [t(3;3)(q22;q23)]  
Fusion : MitelmanPIK3CB/KCNAB1 [3q22.3/3q25.31]  [t(3;3)(q22;q25)]  
Fusion : MitelmanPIK3CB/PCCB [3q22.3/3q22.3]  [t(3;3)(q22;q22)]  
Fusion : MitelmanPIK3CB/TSPO [3q22.3/22q13.2]  [t(3;22)(q22;q13)]  
Fusion: TCGA_MDACCPIK3CB 3q22.3 BFSP2 3q22.1 LUSC
Fusion: TCGA_MDACCPIK3CB 3q22.3 COPB2 3q23 BRCA
Fusion: TCGA_MDACCPIK3CB 3q22.3 KCNAB1 3q25.31 KIRC
Fusion: TCGA_MDACCPIK3CB 3q22.3 PCCB 3q22.3 BRCA
Fusion: TCGA_MDACCPIK3CB 3q22.3 TSPO 22q13.2 BRCA
Tumor Fusion PortalPIK3CB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3CB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3CB
dbVarPIK3CB
ClinVarPIK3CB
1000_GenomesPIK3CB 
Exome Variant ServerPIK3CB
ExAC (Exome Aggregation Consortium)ENSG00000051382
GNOMAD BrowserENSG00000051382
Genetic variants : HAPMAP5291
Genomic Variants (DGV)PIK3CB [DGVbeta]
DECIPHERPIK3CB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3CB 
Mutations
ICGC Data PortalPIK3CB 
TCGA Data PortalPIK3CB 
Broad Tumor PortalPIK3CB
OASIS PortalPIK3CB [ Somatic mutations - Copy number]
Cancer Gene: CensusPIK3CB 
Somatic Mutations in Cancer : COSMICPIK3CB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3CB
intOGen PortalPIK3CB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3CB
DgiDB (Drug Gene Interaction Database)PIK3CB
DoCM (Curated mutations)PIK3CB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3CB (select a term)
intoGenPIK3CB
Cancer3DPIK3CB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602925   
Orphanet
DisGeNETPIK3CB
MedgenPIK3CB
Genetic Testing Registry PIK3CB
NextProtP42338 [Medical]
TSGene5291
GENETestsPIK3CB
Target ValidationPIK3CB
Huge Navigator PIK3CB [HugePedia]
snp3D : Map Gene to Disease5291
BioCentury BCIQPIK3CB
ClinGenPIK3CB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5291
Chemical/Pharm GKB GenePA33309
Clinical trialPIK3CB
Miscellaneous
canSAR (ICR)PIK3CB (select the gene name)
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3CB
EVEXPIK3CB
GoPubMedPIK3CB
iHOPPIK3CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:28:48 CET 2017

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