Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)

Identity

Alias (NCBI)P110BETA
PI3K
PI3KBETA
PIK3C1
HGNC (Hugo) PIK3CB
HGNC Previous namePIK3C1
HGNC Previous namephosphoinositide-3-kinase, catalytic, beta polypeptide
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
LocusID (NCBI) 5291
Atlas_Id 41715
Location 3q22.3  [Link to chromosome band 3q22]
Location_base_pair Starts at 138652698 and ends at 138834928 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP70 (3q22.3)::PIK3CB (3q22.3)PIK3CB (3q22.3)::BFSP2 (3q22.1)PIK3CB (3q22.3)::COPB2 (3q23)
PIK3CB (3q22.3)::KCNAB1 (3q25.31)PIK3CB (3q22.3)::NVL (1q42.11)PIK3CB (3q22.3)::PCCB (3q22.3)
PIK3CB (3q22.3)::TSPO (22q13.2)PIK3CB 3q22.3::BFSP2 3q22.1PIK3CB 3q22.3::COPB2 3q23
PIK3CB 3q22.3::KCNAB1 3q25.31PIK3CB 3q22.3::PCCB 3q22.3PIK3CB 3q22.3::TSPO 22q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;14)(p15;q32)


External links

 

Nomenclature
HGNC (Hugo)PIK3CB   8976
Cards
Entrez_Gene (NCBI)PIK3CB    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
AliasesP110BETA; PI3K; PI3KBETA; PIK3C1
GeneCards (Weizmann)PIK3CB
Ensembl hg19 (Hinxton)ENSG00000051382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000051382 [Gene_View]  ENSG00000051382 [Sequence]  chr3:138652698-138834928 [Contig_View]  PIK3CB [Vega]
ICGC DataPortalENSG00000051382
TCGA cBioPortalPIK3CB
AceView (NCBI)PIK3CB
Genatlas (Paris)PIK3CB
SOURCE (Princeton)PIK3CB
Genetics Home Reference (NIH)PIK3CB
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3CB  -     chr3:138652698-138834928 -  3q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3CB  -     3q22.3   [Description]    (hg19-Feb_2009)
GoldenPathPIK3CB - 3q22.3 [CytoView hg19]  PIK3CB - 3q22.3 [CytoView hg38]
ImmunoBaseENSG00000051382
Genome Data Viewer NCBIPIK3CB [Mapview hg19]  
OMIM602925   
Gene and transcription
Genbank (Entrez)AI623206 AK293754 AK302937 BC003393 BC022049
RefSeq transcript (Entrez)NM_001256045 NM_006219
Consensus coding sequences : CCDS (NCBI)PIK3CB
Gene ExpressionPIK3CB [ NCBI-GEO ]   PIK3CB [ EBI - ARRAY_EXPRESS ]   PIK3CB [ SEEK ]   PIK3CB [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3CB [ Firebrowse - Broad ]
GenevisibleExpression of PIK3CB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5291
GTEX Portal (Tissue expression)PIK3CB
Human Protein AtlasENSG00000051382-PIK3CB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42338   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42338  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42338
PhosPhoSitePlusP42338
Domaine pattern : Prosite (Expaxy)C2_PI3K (PS51547)    PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_ABD (PS51544)    PI3K_RBD (PS51546)    PIK_HELICAL (PS51545)   
Domains : Interpro (EBI)ARM-type_fold    C2_domain_sf    Kinase-like_dom_sf    PI3/4_kinase_cat_dom    PI3/4_kinase_cat_sf    PI3/4_kinase_CS    PI3K_accessory_dom    PI3K_accessory_sf    PI3K_adapt-bd_dom    PI3K_C2_dom    PI3K_Ras-bd_dom    PI3Kbeta_dom    PI_Kinase    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)PI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3K_p85B (PF02192)    PI3K_rbd (PF00794)    PI3Ka (PF00613)   
Domain families : Pfam (NCBI)pfam00454    pfam00792    pfam02192    pfam00794    pfam00613   
Domain families : Smart (EMBL)PI3K_C2 (SM00142)  PI3K_p85B (SM00143)  PI3K_rbd (SM00144)  PI3Ka (SM00145)  PI3Kc (SM00146)  
Conserved Domain (NCBI)PIK3CB
SuperfamilyP42338
AlphaFold pdb e-kbP42338   
Human Protein Atlas [tissue]ENSG00000051382-PIK3CB [tissue]
HPRD04234
Protein Interaction databases
DIP (DOE-UCLA)P42338
IntAct (EBI)P42338
BioGRIDPIK3CB
STRING (EMBL)PIK3CB
ZODIACPIK3CB
Ontologies - Pathways
QuickGOP42338
Ontology : AmiGOendothelial cell proliferation  regulation of cell-matrix adhesion  response to ischemia  sphingosine-1-phosphate receptor signaling pathway  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol 3-kinase complex, class IA  cellular calcium ion homeostasis  endocytosis  autophagy  chemotaxis  homophilic cell adhesion via plasma membrane adhesion molecules  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of autophagy  positive regulation of endothelial cell migration  positive regulation of gene expression  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  kinase activity  1-phosphatidylinositol-3-kinase activity  phosphorylation  cell migration  cell migration  platelet activation  midbody  positive regulation of neutrophil apoptotic process  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  positive regulation of Rac protein signal transduction  phosphatidylinositol-3-phosphate biosynthetic process  embryonic cleavage  intracellular membrane-bounded organelle  negative regulation of MAP kinase activity  insulin receptor substrate binding  phosphatidylinositol phosphate biosynthetic process  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of nitric-oxide synthase activity  positive regulation of protein kinase B signaling  negative regulation of protein kinase B signaling  phosphatidylinositol kinase activity  phosphatidylinositol-3,4-bisphosphate 5-kinase activity  angiogenesis involved in wound healing  platelet aggregation  negative regulation of vascular endothelial growth factor signaling pathway  negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  negative regulation of sprouting angiogenesis  regulation of clathrin-dependent endocytosis  
Ontology : EGO-EBIendothelial cell proliferation  regulation of cell-matrix adhesion  response to ischemia  sphingosine-1-phosphate receptor signaling pathway  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  phosphatidylinositol 3-kinase complex, class IA  cellular calcium ion homeostasis  endocytosis  autophagy  chemotaxis  homophilic cell adhesion via plasma membrane adhesion molecules  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of autophagy  positive regulation of endothelial cell migration  positive regulation of gene expression  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  kinase activity  1-phosphatidylinositol-3-kinase activity  phosphorylation  cell migration  cell migration  platelet activation  midbody  positive regulation of neutrophil apoptotic process  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  positive regulation of Rac protein signal transduction  phosphatidylinositol-3-phosphate biosynthetic process  embryonic cleavage  intracellular membrane-bounded organelle  negative regulation of MAP kinase activity  insulin receptor substrate binding  phosphatidylinositol phosphate biosynthetic process  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of nitric-oxide synthase activity  positive regulation of protein kinase B signaling  negative regulation of protein kinase B signaling  phosphatidylinositol kinase activity  phosphatidylinositol-3,4-bisphosphate 5-kinase activity  angiogenesis involved in wound healing  platelet aggregation  negative regulation of vascular endothelial growth factor signaling pathway  negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  negative regulation of sprouting angiogenesis  regulation of clathrin-dependent endocytosis  
Pathways : KEGGKEGG_INOSITOL_PHOSPHATE_METABOLISM    KEGG_ERBB_SIGNALING    KEGG_CHEMOKINE_SIGNALING    KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM    KEGG_MTOR_SIGNALING    KEGG_APOPTOSIS    KEGG_VEGF_SIGNALING    KEGG_FOCAL_ADHESION    KEGG_TOLL_LIKE_RECEPTOR_SIGNALING    KEGG_JAK_STAT_SIGNALING    KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY    KEGG_T_CELL_RECEPTOR_SIGNALING    KEGG_B_CELL_RECEPTOR_SIGNALING    KEGG_FC_EPSILON_RI_SIGNALING    KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS    KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION    KEGG_NEUROTROPHIN_SIGNALING    KEGG_REGULATION_OF_ACTIN_CYTOSKELETON    KEGG_INSULIN_SIGNALING    KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION    KEGG_TYPE_II_DIABETES_MELLITUS    KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION    KEGG_PATHWAYS_IN_CANCER    KEGG_COLORECTAL_CANCER    KEGG_RENAL_CELL_CARCINOMA    KEGG_PANCREATIC_CANCER    KEGG_ENDOMETRIAL_CANCER    KEGG_GLIOMA    KEGG_PROSTATE_CANCER    KEGG_MELANOMA    KEGG_CHRONIC_MYELOID_LEUKEMIA    KEGG_ACUTE_MYELOID_LEUKEMIA    KEGG_SMALL_CELL_LUNG_CANCER    KEGG_NON_SMALL_CELL_LUNG_CANCER   
NDEx NetworkPIK3CB
Atlas of Cancer Signalling NetworkPIK3CB
Wikipedia pathwaysPIK3CB
Orthology - Evolution
OrthoDB5291
GeneTree (enSembl)ENSG00000051382
Phylogenetic Trees/Animal Genes : TreeFamPIK3CB
Homologs : HomoloGenePIK3CB
Homology/Alignments : Family Browser (UCSC)PIK3CB
Gene fusions - Rearrangements
Fusion : MitelmanPIK3CB::BFSP2 [3q22.3/3q22.1]  
Fusion : MitelmanPIK3CB::COPB2 [3q22.3/3q23]  
Fusion : MitelmanPIK3CB::KCNAB1 [3q22.3/3q25.31]  
Fusion : MitelmanPIK3CB::PCCB [3q22.3/3q22.3]  
Fusion : MitelmanPIK3CB::TSPO [3q22.3/22q13.2]  
Fusion : QuiverPIK3CB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3CB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3CB
dbVarPIK3CB
ClinVarPIK3CB
MonarchPIK3CB
1000_GenomesPIK3CB 
Exome Variant ServerPIK3CB
GNOMAD BrowserENSG00000051382
Varsome BrowserPIK3CB
ACMGPIK3CB variants
VarityP42338
Genomic Variants (DGV)PIK3CB [DGVbeta]
DECIPHERPIK3CB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3CB 
Mutations
ICGC Data PortalPIK3CB 
TCGA Data PortalPIK3CB 
Broad Tumor PortalPIK3CB
OASIS PortalPIK3CB [ Somatic mutations - Copy number]
Cancer Gene: CensusPIK3CB 
Somatic Mutations in Cancer : COSMICPIK3CB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIK3CB
Mutations and Diseases : HGMDPIK3CB
intOGen PortalPIK3CB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPIK3CB
DgiDB (Drug Gene Interaction Database)PIK3CB
DoCM (Curated mutations)PIK3CB
CIViC (Clinical Interpretations of Variants in Cancer)PIK3CB
Cancer3DPIK3CB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602925   
Orphanet
DisGeNETPIK3CB
MedgenPIK3CB
Genetic Testing Registry PIK3CB
NextProtP42338 [Medical]
GENETestsPIK3CB
Target ValidationPIK3CB
Huge Navigator PIK3CB [HugePedia]
ClinGenPIK3CB
Clinical trials, drugs, therapy
MyCancerGenomePIK3CB
Protein Interactions : CTDPIK3CB
Pharm GKB GenePA33309
Pharm GKB PathwaysPA153627758   PA162356267   PA165959584   
PharosP42338
Clinical trialPIK3CB
Miscellaneous
canSAR (ICR)PIK3CB
HarmonizomePIK3CB
ARCHS4PIK3CB
DataMed IndexPIK3CB
Probes
Litterature
PubMed243 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIK3CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:52:17 CET 2022

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