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PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

Identity

Alias_namesphosphoinositide-3-kinase, catalytic, gamma polypeptide
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other aliasPI3CG
PI3K
PI3Kgamma
PIK3
p110gamma
p120-PI3K
HGNC (Hugo) PIK3CG
LocusID (NCBI) 5294
Atlas_Id 41716
Location 7q22.3  [Link to chromosome band 7q22]
Location_base_pair Starts at 106505723 and ends at 106549423 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3CG   8978
Cards
Entrez_Gene (NCBI)PIK3CG  5294  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
AliasesPI3CG; PI3K; PI3Kgamma; PIK3; 
p110gamma; p120-PI3K
GeneCards (Weizmann)PIK3CG
Ensembl hg19 (Hinxton)ENSG00000105851 [Gene_View]  chr7:106505723-106549423 [Contig_View]  PIK3CG [Vega]
Ensembl hg38 (Hinxton)ENSG00000105851 [Gene_View]  chr7:106505723-106549423 [Contig_View]  PIK3CG [Vega]
ICGC DataPortalENSG00000105851
TCGA cBioPortalPIK3CG
AceView (NCBI)PIK3CG
Genatlas (Paris)PIK3CG
WikiGenes5294
SOURCE (Princeton)PIK3CG
Genetics Home Reference (NIH)PIK3CG
Genomic and cartography
GoldenPath hg19 (UCSC)PIK3CG  -     chr7:106505723-106549423 +  7q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PIK3CG  -     7q22.3   [Description]    (hg38-Dec_2013)
EnsemblPIK3CG - 7q22.3 [CytoView hg19]  PIK3CG - 7q22.3 [CytoView hg38]
Mapping of homologs : NCBIPIK3CG [Mapview hg19]  PIK3CG [Mapview hg38]
OMIM601232   
Gene and transcription
Genbank (Entrez)AA810265 AF327656 AK292684 AK313753 AY496423
RefSeq transcript (Entrez)NM_001282426 NM_001282427 NM_002649
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)PIK3CG
Cluster EST : UnigeneHs.561747 [ NCBI ]
CGAP (NCI)Hs.561747
Alternative Splicing GalleryENSG00000105851
Gene ExpressionPIK3CG [ NCBI-GEO ]   PIK3CG [ EBI - ARRAY_EXPRESS ]   PIK3CG [ SEEK ]   PIK3CG [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3CG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5294
GTEX Portal (Tissue expression)PIK3CG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48736   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48736  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48736
Splice isoforms : SwissVarP48736
Catalytic activity : Enzyme2.7.1.153 [ Enzyme-Expasy ]   2.7.1.1532.7.1.153 [ IntEnz-EBI ]   2.7.1.153 [ BRENDA ]   2.7.1.153 [ KEGG ]   
PhosPhoSitePlusP48736
Domaine pattern : Prosite (Expaxy)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_ABD (PS51544)    PI3K_C2 (PS51547)    PI3K_RBD (PS51546)    PIK_HELICAL (PS51545)   
Domains : Interpro (EBI)ARM-type_fold    C2_dom    Kinase-like_dom    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI3K_adapt-bd_dom    PI3K_C2_dom    PI3K_Ras-bd_dom    PI_Kinase    PInositide-3_kin_accessory_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)PI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3K_rbd (PF00794)    PI3Ka (PF00613)   
Domain families : Pfam (NCBI)pfam00454    pfam00792    pfam00794    pfam00613   
Domain families : Smart (EMBL)PI3K_C2 (SM00142)  PI3K_rbd (SM00144)  PI3Ka (SM00145)  PI3Kc (SM00146)  
Conserved Domain (NCBI)PIK3CG
DMDM Disease mutations5294
Blocks (Seattle)PIK3CG
PDB (SRS)1E8Y    1E8Z    1HE8    2A4Z    2A5U    2CHW    2CHX    2CHZ    2V4L    3APC    3APD    3APF    3CSF    3CST    3DBS    3DPD    3ENE    3IBE    3L08    3L13    3L16    3L17    3L54    3LJ3    3MJW    3ML8    3ML9    3NZS    3NZU    3OAW    3P2B    3PRE    3PRZ    3PS6    3QAQ    3QAR    3QJZ    3QK0    3R7Q    3R7R    3S2A    3SD5    3T8M    3TJP    3TL5    3ZVV    3ZW3    4ANU    4ANV    4ANW    4ANX    4AOF    4DK5    4EZJ    4EZK    4EZL    4F1S    4FA6    4FAD    4FHJ    4FHK    4FJY    4FJZ    4FLH    4FUL    4G11    4GB9    4HLE    4HVB    4J6I    4KZ0    4KZC    4PS3    4PS7    4PS8    4URK    4WWN    4WWO    4WWP    4XX5    4XZ4    5EDS   
PDB (PDBSum)1E8Y    1E8Z    1HE8    2A4Z    2A5U    2CHW    2CHX    2CHZ    2V4L    3APC    3APD    3APF    3CSF    3CST    3DBS    3DPD    3ENE    3IBE    3L08    3L13    3L16    3L17    3L54    3LJ3    3MJW    3ML8    3ML9    3NZS    3NZU    3OAW    3P2B    3PRE    3PRZ    3PS6    3QAQ    3QAR    3QJZ    3QK0    3R7Q    3R7R    3S2A    3SD5    3T8M    3TJP    3TL5    3ZVV    3ZW3    4ANU    4ANV    4ANW    4ANX    4AOF    4DK5    4EZJ    4EZK    4EZL    4F1S    4FA6    4FAD    4FHJ    4FHK    4FJY    4FJZ    4FLH    4FUL    4G11    4GB9    4HLE    4HVB    4J6I    4KZ0    4KZC    4PS3    4PS7    4PS8    4URK    4WWN    4WWO    4WWP    4XX5    4XZ4    5EDS   
PDB (IMB)1E8Y    1E8Z    1HE8    2A4Z    2A5U    2CHW    2CHX    2CHZ    2V4L    3APC    3APD    3APF    3CSF    3CST    3DBS    3DPD    3ENE    3IBE    3L08    3L13    3L16    3L17    3L54    3LJ3    3MJW    3ML8    3ML9    3NZS    3NZU    3OAW    3P2B    3PRE    3PRZ    3PS6    3QAQ    3QAR    3QJZ    3QK0    3R7Q    3R7R    3S2A    3SD5    3T8M    3TJP    3TL5    3ZVV    3ZW3    4ANU    4ANV    4ANW    4ANX    4AOF    4DK5    4EZJ    4EZK    4EZL    4F1S    4FA6    4FAD    4FHJ    4FHK    4FJY    4FJZ    4FLH    4FUL    4G11    4GB9    4HLE    4HVB    4J6I    4KZ0    4KZC    4PS3    4PS7    4PS8    4URK    4WWN    4WWO    4WWP    4XX5    4XZ4    5EDS   
PDB (RSDB)1E8Y    1E8Z    1HE8    2A4Z    2A5U    2CHW    2CHX    2CHZ    2V4L    3APC    3APD    3APF    3CSF    3CST    3DBS    3DPD    3ENE    3IBE    3L08    3L13    3L16    3L17    3L54    3LJ3    3MJW    3ML8    3ML9    3NZS    3NZU    3OAW    3P2B    3PRE    3PRZ    3PS6    3QAQ    3QAR    3QJZ    3QK0    3R7Q    3R7R    3S2A    3SD5    3T8M    3TJP    3TL5    3ZVV    3ZW3    4ANU    4ANV    4ANW    4ANX    4AOF    4DK5    4EZJ    4EZK    4EZL    4F1S    4FA6    4FAD    4FHJ    4FHK    4FJY    4FJZ    4FLH    4FUL    4G11    4GB9    4HLE    4HVB    4J6I    4KZ0    4KZC    4PS3    4PS7    4PS8    4URK    4WWN    4WWO    4WWP    4XX5    4XZ4    5EDS   
Structural Biology KnowledgeBase1E8Y    1E8Z    1HE8    2A4Z    2A5U    2CHW    2CHX    2CHZ    2V4L    3APC    3APD    3APF    3CSF    3CST    3DBS    3DPD    3ENE    3IBE    3L08    3L13    3L16    3L17    3L54    3LJ3    3MJW    3ML8    3ML9    3NZS    3NZU    3OAW    3P2B    3PRE    3PRZ    3PS6    3QAQ    3QAR    3QJZ    3QK0    3R7Q    3R7R    3S2A    3SD5    3T8M    3TJP    3TL5    3ZVV    3ZW3    4ANU    4ANV    4ANW    4ANX    4AOF    4DK5    4EZJ    4EZK    4EZL    4F1S    4FA6    4FAD    4FHJ    4FHK    4FJY    4FJZ    4FLH    4FUL    4G11    4GB9    4HLE    4HVB    4J6I    4KZ0    4KZC    4PS3    4PS7    4PS8    4URK    4WWN    4WWO    4WWP    4XX5    4XZ4    5EDS   
SCOP (Structural Classification of Proteins)1E8Y    1E8Z    1HE8    2A4Z    2A5U    2CHW    2CHX    2CHZ    2V4L    3APC    3APD    3APF    3CSF    3CST    3DBS    3DPD    3ENE    3IBE    3L08    3L13    3L16    3L17    3L54    3LJ3    3MJW    3ML8    3ML9    3NZS    3NZU    3OAW    3P2B    3PRE    3PRZ    3PS6    3QAQ    3QAR    3QJZ    3QK0    3R7Q    3R7R    3S2A    3SD5    3T8M    3TJP    3TL5    3ZVV    3ZW3    4ANU    4ANV    4ANW    4ANX    4AOF    4DK5    4EZJ    4EZK    4EZL    4F1S    4FA6    4FAD    4FHJ    4FHK    4FJY    4FJZ    4FLH    4FUL    4G11    4GB9    4HLE    4HVB    4J6I    4KZ0    4KZC    4PS3    4PS7    4PS8    4URK    4WWN    4WWO    4WWP    4XX5    4XZ4    5EDS   
CATH (Classification of proteins structures)1E8Y    1E8Z    1HE8    2A4Z    2A5U    2CHW    2CHX    2CHZ    2V4L    3APC    3APD    3APF    3CSF    3CST    3DBS    3DPD    3ENE    3IBE    3L08    3L13    3L16    3L17    3L54    3LJ3    3MJW    3ML8    3ML9    3NZS    3NZU    3OAW    3P2B    3PRE    3PRZ    3PS6    3QAQ    3QAR    3QJZ    3QK0    3R7Q    3R7R    3S2A    3SD5    3T8M    3TJP    3TL5    3ZVV    3ZW3    4ANU    4ANV    4ANW    4ANX    4AOF    4DK5    4EZJ    4EZK    4EZL    4F1S    4FA6    4FAD    4FHJ    4FHK    4FJY    4FJZ    4FLH    4FUL    4G11    4GB9    4HLE    4HVB    4J6I    4KZ0    4KZC    4PS3    4PS7    4PS8    4URK    4WWN    4WWO    4WWP    4XX5    4XZ4    5EDS   
SuperfamilyP48736
Human Protein AtlasENSG00000105851
Peptide AtlasP48736
HPRD03135
IPIIPI00292690   IPI00946767   
Protein Interaction databases
DIP (DOE-UCLA)P48736
IntAct (EBI)P48736
FunCoupENSG00000105851
BioGRIDPIK3CG
STRING (EMBL)PIK3CG
ZODIACPIK3CG
Ontologies - Pathways
QuickGOP48736
Ontology : AmiGOangiogenesis  cytokine production  adaptive immune response  dendritic cell chemotaxis  positive regulation of acute inflammatory response  respiratory burst involved in defense response  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex, class IB  protein phosphorylation  phosphatidylinositol biosynthetic process  endocytosis  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  T cell chemotaxis  negative regulation of triglyceride catabolic process  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  1-phosphatidylinositol-3-kinase activity  platelet activation  neutrophil chemotaxis  secretory granule localization  regulation of cell adhesion mediated by integrin  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  natural killer cell chemotaxis  phosphatidylinositol-3-phosphate biosynthetic process  T cell proliferation  T cell activation  mast cell granule  mast cell degranulation  positive regulation of MAP kinase activity  innate immune response  phosphatidylinositol phosphorylation  ephrin receptor binding  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  negative regulation of cardiac muscle contraction  platelet aggregation  cellular response to cAMP  neutrophil extravasation  hepatocyte apoptotic process  regulation of calcium ion transmembrane transport  negative regulation of fibroblast apoptotic process  
Ontology : EGO-EBIangiogenesis  cytokine production  adaptive immune response  dendritic cell chemotaxis  positive regulation of acute inflammatory response  respiratory burst involved in defense response  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex, class IB  protein phosphorylation  phosphatidylinositol biosynthetic process  endocytosis  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  T cell chemotaxis  negative regulation of triglyceride catabolic process  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  1-phosphatidylinositol-3-kinase activity  platelet activation  neutrophil chemotaxis  secretory granule localization  regulation of cell adhesion mediated by integrin  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  natural killer cell chemotaxis  phosphatidylinositol-3-phosphate biosynthetic process  T cell proliferation  T cell activation  mast cell granule  mast cell degranulation  positive regulation of MAP kinase activity  innate immune response  phosphatidylinositol phosphorylation  ephrin receptor binding  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  negative regulation of cardiac muscle contraction  platelet aggregation  cellular response to cAMP  neutrophil extravasation  hepatocyte apoptotic process  regulation of calcium ion transmembrane transport  negative regulation of fibroblast apoptotic process  
Pathways : BIOCARTAB Cell Survival Pathway [Genes]    Corticosteroids and cardioprotection [Genes]    Insulin Signaling Pathway [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    PDGF Signaling Pathway [Genes]    AKT Signaling Pathway [Genes]    Phospholipids as signalling intermediaries [Genes]    Role of Erk5 in Neuronal Survival [Genes]    Growth Hormone Signaling Pathway [Genes]    IL-7 Signal Transduction [Genes]    The IGF-1 Receptor and Longevity [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    Rac 1 cell motility signaling pathway [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    T Cell Receptor Signaling Pathway [Genes]    CTCF: First Multivalent Nuclear Factor [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Nerve growth factor pathway (NGF) [Genes]    Phospholipase C Signaling Pathway [Genes]    Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    Thrombin signaling and protease-activated receptors [Genes]    TPO Signaling Pathway [Genes]    IGF-1 Signaling Pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Tumor Suppressor Arf Inhibits Ribosomal Biogenesis [Genes]    Regulation of BAD phosphorylation [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    Ras Signaling Pathway [Genes]    VEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGGInositol phosphate metabolism    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    Phosphatidylinositol signaling system    mTOR signaling pathway    PI3K-Akt signaling pathway    Apoptosis    Adrenergic signaling in cardiomyocytes    VEGF signaling pathway    Osteoclast differentiation    Focal adhesion    Toll-like receptor signaling pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    TNF signaling pathway    Leukocyte transendothelial migration    Neurotrophin signaling pathway    Cholinergic synapse    Regulation of actin cytoskeleton    Insulin signaling pathway    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Prolactin signaling pathway    Thyroid hormone signaling pathway    Type II diabetes mellitus    Non-alcoholic fatty liver disease (NAFLD)    Aldosterone-regulated sodium reabsorption    Carbohydrate digestion and absorption    Bacterial invasion of epithelial cells    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Amoebiasis    Hepatitis C    Hepatitis B    Measles    Influenza A    HTLV-I infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    Colorectal cancer    Renal cell carcinoma    Pancreatic cancer    Endometrial cancer    Glioma    Prostate cancer    Melanoma    Chronic myeloid leukemia    Acute myeloid leukemia    Small cell lung cancer    Non-small cell lung cancer   
NDEx NetworkPIK3CG
Atlas of Cancer Signalling NetworkPIK3CG
Wikipedia pathwaysPIK3CG
Orthology - Evolution
OrthoDB5294
GeneTree (enSembl)ENSG00000105851
Phylogenetic Trees/Animal Genes : TreeFamPIK3CG
HOVERGENP48736
HOGENOMP48736
Homologs : HomoloGenePIK3CG
Homology/Alignments : Family Browser (UCSC)PIK3CG
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3CG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3CG
dbVarPIK3CG
ClinVarPIK3CG
1000_GenomesPIK3CG 
Exome Variant ServerPIK3CG
ExAC (Exome Aggregation Consortium)PIK3CG (select the gene name)
Genetic variants : HAPMAP5294
Genomic Variants (DGV)PIK3CG [DGVbeta]
DECIPHER (Syndromes)7:106505723-106549423  ENSG00000105851
CONAN: Copy Number AnalysisPIK3CG 
Mutations
ICGC Data PortalPIK3CG 
TCGA Data PortalPIK3CG 
Broad Tumor PortalPIK3CG
OASIS PortalPIK3CG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3CG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3CG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3CG
DgiDB (Drug Gene Interaction Database)PIK3CG
DoCM (Curated mutations)PIK3CG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3CG (select a term)
intoGenPIK3CG
Cancer3DPIK3CG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601232   
Orphanet
MedgenPIK3CG
Genetic Testing Registry PIK3CG
NextProtP48736 [Medical]
TSGene5294
GENETestsPIK3CG
Huge Navigator PIK3CG [HugePedia]
snp3D : Map Gene to Disease5294
BioCentury BCIQPIK3CG
ClinGenPIK3CG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5294
Chemical/Pharm GKB GenePA33311
Clinical trialPIK3CG
Miscellaneous
canSAR (ICR)PIK3CG (select the gene name)
Probes
Litterature
PubMed403 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3CG
EVEXPIK3CG
GoPubMedPIK3CG
iHOPPIK3CG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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