Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

Identity

Alias_namesphosphoinositide-3-kinase, catalytic, gamma polypeptide
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other aliasPI3CG
PI3K
PI3Kgamma
PIK3
p110gamma
p120-PI3K
HGNC (Hugo) PIK3CG
LocusID (NCBI) 5294
Atlas_Id 41716
Location 7q22.3  [Link to chromosome band 7q22]
Location_base_pair Starts at 106865278 and ends at 106908978 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3CG   8978
Cards
Entrez_Gene (NCBI)PIK3CG  5294  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
AliasesPI3CG; PI3K; PI3Kgamma; PIK3; 
p110gamma; p120-PI3K
GeneCards (Weizmann)PIK3CG
Ensembl hg19 (Hinxton)ENSG00000105851 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105851 [Gene_View]  chr7:106865278-106908978 [Contig_View]  PIK3CG [Vega]
ICGC DataPortalENSG00000105851
TCGA cBioPortalPIK3CG
AceView (NCBI)PIK3CG
Genatlas (Paris)PIK3CG
WikiGenes5294
SOURCE (Princeton)PIK3CG
Genetics Home Reference (NIH)PIK3CG
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3CG  -     chr7:106865278-106908978 +  7q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3CG  -     7q22.3   [Description]    (hg19-Feb_2009)
EnsemblPIK3CG - 7q22.3 [CytoView hg19]  PIK3CG - 7q22.3 [CytoView hg38]
Mapping of homologs : NCBIPIK3CG [Mapview hg19]  PIK3CG [Mapview hg38]
OMIM601232   
Gene and transcription
Genbank (Entrez)AA810265 AF327656 AK292684 AK313753 AY496423
RefSeq transcript (Entrez)NM_001282426 NM_001282427 NM_002649
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3CG
Cluster EST : UnigeneHs.561747 [ NCBI ]
CGAP (NCI)Hs.561747
Alternative Splicing GalleryENSG00000105851
Gene ExpressionPIK3CG [ NCBI-GEO ]   PIK3CG [ EBI - ARRAY_EXPRESS ]   PIK3CG [ SEEK ]   PIK3CG [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3CG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5294
GTEX Portal (Tissue expression)PIK3CG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48736   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48736  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48736
Splice isoforms : SwissVarP48736
Catalytic activity : Enzyme2.7.1.153 [ Enzyme-Expasy ]   2.7.1.1532.7.1.153 [ IntEnz-EBI ]   2.7.1.153 [ BRENDA ]   2.7.1.153 [ KEGG ]   
PhosPhoSitePlusP48736
Domaine pattern : Prosite (Expaxy)PI3_4_KINASE_1 (PS00915)    PI3_4_KINASE_2 (PS00916)    PI3_4_KINASE_3 (PS50290)    PI3K_ABD (PS51544)    PI3K_C2 (PS51547)    PI3K_RBD (PS51546)    PIK_HELICAL (PS51545)   
Domains : Interpro (EBI)ARM-type_fold    C2_dom    Kinase-like_dom    PI3/4_kinase_cat_dom    PI3/4_kinase_CS    PI3K_adapt-bd_dom    PI3K_C2_dom    PI3K_Ras-bd_dom    PI_Kinase    PInositide-3_kin_accessory_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)PI3_PI4_kinase (PF00454)    PI3K_C2 (PF00792)    PI3K_rbd (PF00794)    PI3Ka (PF00613)   
Domain families : Pfam (NCBI)pfam00454    pfam00792    pfam00794    pfam00613   
Domain families : Smart (EMBL)PI3K_C2 (SM00142)  PI3K_rbd (SM00144)  PI3Ka (SM00145)  PI3Kc (SM00146)  
Conserved Domain (NCBI)PIK3CG
DMDM Disease mutations5294
Blocks (Seattle)PIK3CG
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP48736
Human Protein AtlasENSG00000105851
Peptide AtlasP48736
HPRD03135
IPIIPI00292690   IPI00946767   
Protein Interaction databases
DIP (DOE-UCLA)P48736
IntAct (EBI)P48736
FunCoupENSG00000105851
BioGRIDPIK3CG
STRING (EMBL)PIK3CG
ZODIACPIK3CG
Ontologies - Pathways
QuickGOP48736
Ontology : AmiGOangiogenesis  cytokine production  adaptive immune response  dendritic cell chemotaxis  positive regulation of acute inflammatory response  respiratory burst involved in defense response  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  plasma membrane  phosphatidylinositol 3-kinase complex, class IB  protein phosphorylation  phosphatidylinositol biosynthetic process  endocytosis  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  T cell chemotaxis  negative regulation of triglyceride catabolic process  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  kinase activity  1-phosphatidylinositol-3-kinase activity  phosphorylation  platelet activation  neutrophil chemotaxis  secretory granule localization  regulation of cell adhesion mediated by integrin  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  natural killer cell chemotaxis  phosphatidylinositol-3-phosphate biosynthetic process  T cell proliferation  T cell activation  mast cell granule  mast cell degranulation  positive regulation of MAP kinase activity  innate immune response  phosphatidylinositol phosphorylation  ephrin receptor binding  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  negative regulation of cardiac muscle contraction  platelet aggregation  cellular response to cAMP  neutrophil extravasation  hepatocyte apoptotic process  regulation of calcium ion transmembrane transport  negative regulation of fibroblast apoptotic process  
Ontology : EGO-EBIangiogenesis  cytokine production  adaptive immune response  dendritic cell chemotaxis  positive regulation of acute inflammatory response  respiratory burst involved in defense response  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  plasma membrane  phosphatidylinositol 3-kinase complex, class IB  protein phosphorylation  phosphatidylinositol biosynthetic process  endocytosis  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  T cell chemotaxis  negative regulation of triglyceride catabolic process  phosphatidylinositol 3-kinase signaling  phosphatidylinositol 3-kinase signaling  membrane  kinase activity  1-phosphatidylinositol-3-kinase activity  phosphorylation  platelet activation  neutrophil chemotaxis  secretory granule localization  regulation of cell adhesion mediated by integrin  phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-4-phosphate 3-kinase activity  natural killer cell chemotaxis  phosphatidylinositol-3-phosphate biosynthetic process  T cell proliferation  T cell activation  mast cell granule  mast cell degranulation  positive regulation of MAP kinase activity  innate immune response  phosphatidylinositol phosphorylation  ephrin receptor binding  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  negative regulation of cardiac muscle contraction  platelet aggregation  cellular response to cAMP  neutrophil extravasation  hepatocyte apoptotic process  regulation of calcium ion transmembrane transport  negative regulation of fibroblast apoptotic process  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkPIK3CG
Atlas of Cancer Signalling NetworkPIK3CG
Wikipedia pathwaysPIK3CG
Orthology - Evolution
OrthoDB5294
GeneTree (enSembl)ENSG00000105851
Phylogenetic Trees/Animal Genes : TreeFamPIK3CG
HOVERGENP48736
HOGENOMP48736
Homologs : HomoloGenePIK3CG
Homology/Alignments : Family Browser (UCSC)PIK3CG
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3CG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3CG
dbVarPIK3CG
ClinVarPIK3CG
1000_GenomesPIK3CG 
Exome Variant ServerPIK3CG
ExAC (Exome Aggregation Consortium)PIK3CG (select the gene name)
Genetic variants : HAPMAP5294
Genomic Variants (DGV)PIK3CG [DGVbeta]
DECIPHERPIK3CG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3CG 
Mutations
ICGC Data PortalPIK3CG 
TCGA Data PortalPIK3CG 
Broad Tumor PortalPIK3CG
OASIS PortalPIK3CG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3CG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3CG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3CG
DgiDB (Drug Gene Interaction Database)PIK3CG
DoCM (Curated mutations)PIK3CG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3CG (select a term)
intoGenPIK3CG
Cancer3DPIK3CG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601232   
Orphanet
MedgenPIK3CG
Genetic Testing Registry PIK3CG
NextProtP48736 [Medical]
TSGene5294
GENETestsPIK3CG
Huge Navigator PIK3CG [HugePedia]
snp3D : Map Gene to Disease5294
BioCentury BCIQPIK3CG
ClinGenPIK3CG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5294
Chemical/Pharm GKB GenePA33311
Clinical trialPIK3CG
Miscellaneous
canSAR (ICR)PIK3CG (select the gene name)
Probes
Litterature
PubMed408 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3CG
EVEXPIK3CG
GoPubMedPIK3CG
iHOPPIK3CG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:31:15 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.