Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PIK3IP1 (phosphoinositide-3-kinase interacting protein 1)

Identity

Alias (NCBI)HGFL
TrIP
hHGFL(S)
HGNC (Hugo) PIK3IP1
HGNC Alias symbHGFL
MGC17330
TrIP
HGNC Alias nametransmembrane inhibitor of PI3K
LocusID (NCBI) 113791
Atlas_Id 50366
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 31281611 and ends at 31292488 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGA (4q31.3) / PIK3IP1 (22q12.2)HNRNPH1 (5q35.3) / PIK3IP1 (22q12.2)LINC00476 (9q22.32) / PIK3IP1 (22q12.2)
PIK3IP1 (22q12.2) / PIK3IP1 (22q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)PIK3IP1   24942
Cards
Entrez_Gene (NCBI)PIK3IP1    phosphoinositide-3-kinase interacting protein 1
AliasesHGFL; TrIP; hHGFL(S)
GeneCards (Weizmann)PIK3IP1
Ensembl hg19 (Hinxton)ENSG00000100100 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100100 [Gene_View]  ENSG00000100100 [Sequence]  chr22:31281611-31292488 [Contig_View]  PIK3IP1 [Vega]
ICGC DataPortalENSG00000100100
TCGA cBioPortalPIK3IP1
AceView (NCBI)PIK3IP1
Genatlas (Paris)PIK3IP1
SOURCE (Princeton)PIK3IP1
Genetics Home Reference (NIH)PIK3IP1
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3IP1  -     chr22:31281611-31292488 -  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3IP1  -     22q12.2   [Description]    (hg19-Feb_2009)
GoldenPathPIK3IP1 - 22q12.2 [CytoView hg19]  PIK3IP1 - 22q12.2 [CytoView hg38]
ImmunoBaseENSG00000100100
Genome Data Viewer NCBIPIK3IP1 [Mapview hg19]  
OMIM619158   
Gene and transcription
Genbank (Entrez)AF528079 AF528080 AK074688 AK093768 AK226089
RefSeq transcript (Entrez)NM_001135911 NM_052880
Consensus coding sequences : CCDS (NCBI)PIK3IP1
Gene ExpressionPIK3IP1 [ NCBI-GEO ]   PIK3IP1 [ EBI - ARRAY_EXPRESS ]   PIK3IP1 [ SEEK ]   PIK3IP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3IP1 [ Firebrowse - Broad ]
GenevisibleExpression of PIK3IP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)113791
GTEX Portal (Tissue expression)PIK3IP1
Human Protein AtlasENSG00000100100-PIK3IP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96FE7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96FE7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96FE7
PhosPhoSitePlusQ96FE7
Domaine pattern : Prosite (Expaxy)KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)   
Domains : Interpro (EBI)Kringle    Kringle-like    Kringle_CS    Kringle_sf   
Domain families : Pfam (Sanger)Kringle (PF00051)   
Domain families : Pfam (NCBI)pfam00051   
Domain families : Smart (EMBL)KR (SM00130)  
Conserved Domain (NCBI)PIK3IP1
SuperfamilyQ96FE7
AlphaFold pdb e-kbQ96FE7   
Human Protein Atlas [tissue]ENSG00000100100-PIK3IP1 [tissue]
HPRD17518
Protein Interaction databases
DIP (DOE-UCLA)Q96FE7
IntAct (EBI)Q96FE7
BioGRIDPIK3IP1
STRING (EMBL)PIK3IP1
ZODIACPIK3IP1
Ontologies - Pathways
QuickGOQ96FE7
Ontology : AmiGOserine-type endopeptidase activity  protein binding  plasma membrane  proteolysis  negative regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  phosphatidylinositol 3-kinase catalytic subunit binding  negative regulation of phosphatidylinositol 3-kinase activity  negative regulation of phosphatidylinositol 3-kinase activity  
Ontology : EGO-EBIserine-type endopeptidase activity  protein binding  plasma membrane  proteolysis  negative regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  phosphatidylinositol 3-kinase catalytic subunit binding  negative regulation of phosphatidylinositol 3-kinase activity  negative regulation of phosphatidylinositol 3-kinase activity  
NDEx NetworkPIK3IP1
Atlas of Cancer Signalling NetworkPIK3IP1
Wikipedia pathwaysPIK3IP1
Orthology - Evolution
OrthoDB113791
GeneTree (enSembl)ENSG00000100100
Phylogenetic Trees/Animal Genes : TreeFamPIK3IP1
Homologs : HomoloGenePIK3IP1
Homology/Alignments : Family Browser (UCSC)PIK3IP1
Gene fusions - Rearrangements
Fusion : QuiverPIK3IP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3IP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3IP1
dbVarPIK3IP1
ClinVarPIK3IP1
MonarchPIK3IP1
1000_GenomesPIK3IP1 
Exome Variant ServerPIK3IP1
GNOMAD BrowserENSG00000100100
Varsome BrowserPIK3IP1
ACMGPIK3IP1 variants
VarityQ96FE7
Genomic Variants (DGV)PIK3IP1 [DGVbeta]
DECIPHERPIK3IP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3IP1 
Mutations
ICGC Data PortalPIK3IP1 
TCGA Data PortalPIK3IP1 
Broad Tumor PortalPIK3IP1
OASIS PortalPIK3IP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3IP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIK3IP1
Mutations and Diseases : HGMDPIK3IP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPIK3IP1
DgiDB (Drug Gene Interaction Database)PIK3IP1
DoCM (Curated mutations)PIK3IP1
CIViC (Clinical Interpretations of Variants in Cancer)PIK3IP1
Cancer3DPIK3IP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619158   
Orphanet
DisGeNETPIK3IP1
MedgenPIK3IP1
Genetic Testing Registry PIK3IP1
NextProtQ96FE7 [Medical]
GENETestsPIK3IP1
Target ValidationPIK3IP1
Huge Navigator PIK3IP1 [HugePedia]
ClinGenPIK3IP1
Clinical trials, drugs, therapy
MyCancerGenomePIK3IP1
Protein Interactions : CTDPIK3IP1
Pharm GKB GenePA162399553
PharosQ96FE7
Clinical trialPIK3IP1
Miscellaneous
canSAR (ICR)PIK3IP1
HarmonizomePIK3IP1
DataMed IndexPIK3IP1
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIK3IP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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