Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)

Identity

Alias_namesphosphoinositide-3-kinase
Alias_symbol (synonym)p55
Other aliasp55-GAMMA
p55PIK
HGNC (Hugo) PIK3R3
LocusID (NCBI) 8503
Atlas_Id 53226
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 46040140 and ends at 46133036 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PIK3R3 (1p34.1) / AP2A1 (19q13.33)PIK3R3 (1p34.1) / LRRC41 (1p34.1)PIK3R3 (1p34.1) / ZSWIM5 (1p34.1)
UQCRH (1p34.1) / PIK3R3 (1p34.1)PIK3R3 1p34.1 / LRRC41 1p34.1PIK3R3 1p34.1 / ZSWIM5 1p34.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIK3R3   8981
Cards
Entrez_Gene (NCBI)PIK3R3  8503  phosphoinositide-3-kinase regulatory subunit 3
Aliasesp55; p55-GAMMA; p55PIK
GeneCards (Weizmann)PIK3R3
Ensembl hg19 (Hinxton)ENSG00000117461 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117461 [Gene_View]  chr1:46040140-46133036 [Contig_View]  PIK3R3 [Vega]
ICGC DataPortalENSG00000117461
TCGA cBioPortalPIK3R3
AceView (NCBI)PIK3R3
Genatlas (Paris)PIK3R3
WikiGenes8503
SOURCE (Princeton)PIK3R3
Genetics Home Reference (NIH)PIK3R3
Genomic and cartography
GoldenPath hg38 (UCSC)PIK3R3  -     chr1:46040140-46133036 -  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIK3R3  -     1p34.1   [Description]    (hg19-Feb_2009)
EnsemblPIK3R3 - 1p34.1 [CytoView hg19]  PIK3R3 - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBIPIK3R3 [Mapview hg19]  PIK3R3 [Mapview hg38]
OMIM606076   
Gene and transcription
Genbank (Entrez)AF028785 AK304713 AK313726 BC005381 BC021622
RefSeq transcript (Entrez)NM_001114172 NM_001303428 NM_001303429 NM_001328648 NM_001328649 NM_001328650 NM_001328651 NM_001328652 NM_001328653 NM_001328654 NM_003629
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIK3R3
Cluster EST : UnigeneHs.655387 [ NCBI ]
CGAP (NCI)Hs.655387
Alternative Splicing GalleryENSG00000117461
Gene ExpressionPIK3R3 [ NCBI-GEO ]   PIK3R3 [ EBI - ARRAY_EXPRESS ]   PIK3R3 [ SEEK ]   PIK3R3 [ MEM ]
Gene Expression Viewer (FireBrowse)PIK3R3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8503
GTEX Portal (Tissue expression)PIK3R3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92569   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92569  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92569
Splice isoforms : SwissVarQ92569
PhosPhoSitePlusQ92569
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)PI3K_P85_iSH2    PI3kinase_P85    SH2   
Domain families : Pfam (Sanger)PI3K_P85_iSH2 (PF16454)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam16454    pfam00017   
Domain families : Smart (EMBL)SH2 (SM00252)  
Conserved Domain (NCBI)PIK3R3
DMDM Disease mutations8503
Blocks (Seattle)PIK3R3
SuperfamilyQ92569
Human Protein AtlasENSG00000117461
Peptide AtlasQ92569
HPRD05831
IPIIPI00513745   IPI00220498   IPI00220499   IPI00910186   IPI01018685   IPI00643776   
Protein Interaction databases
DIP (DOE-UCLA)Q92569
IntAct (EBI)Q92569
FunCoupENSG00000117461
BioGRIDPIK3R3
STRING (EMBL)PIK3R3
ZODIACPIK3R3
Ontologies - Pathways
QuickGOQ92569
Ontology : AmiGOphosphotyrosine binding  protein binding  cytosol  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  insulin receptor signaling pathway  1-phosphatidylinositol-3-kinase activity  phosphatidylinositol-3-phosphate biosynthetic process  regulation of phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-3-kinase regulator activity  positive regulation of glucose import in response to insulin stimulus  
Ontology : EGO-EBIphosphotyrosine binding  protein binding  cytosol  phosphatidylinositol 3-kinase complex  phosphatidylinositol biosynthetic process  insulin receptor signaling pathway  1-phosphatidylinositol-3-kinase activity  phosphatidylinositol-3-phosphate biosynthetic process  regulation of phosphatidylinositol 3-kinase activity  1-phosphatidylinositol-3-kinase regulator activity  positive regulation of glucose import in response to insulin stimulus  
Pathways : KEGG   
NDEx NetworkPIK3R3
Atlas of Cancer Signalling NetworkPIK3R3
Wikipedia pathwaysPIK3R3
Orthology - Evolution
OrthoDB8503
GeneTree (enSembl)ENSG00000117461
Phylogenetic Trees/Animal Genes : TreeFamPIK3R3
HOVERGENQ92569
HOGENOMQ92569
Homologs : HomoloGenePIK3R3
Homology/Alignments : Family Browser (UCSC)PIK3R3
Gene fusions - Rearrangements
Fusion : MitelmanPIK3R3/LRRC41 [1p34.1/1p34.1]  
Fusion : MitelmanPIK3R3/ZSWIM5 [1p34.1/1p34.1]  [t(1;1)(p34;p34)]  
Fusion: TCGAPIK3R3 1p34.1 LRRC41 1p34.1 BRCA
Fusion: TCGAPIK3R3 1p34.1 ZSWIM5 1p34.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIK3R3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIK3R3
dbVarPIK3R3
ClinVarPIK3R3
1000_GenomesPIK3R3 
Exome Variant ServerPIK3R3
ExAC (Exome Aggregation Consortium)PIK3R3 (select the gene name)
Genetic variants : HAPMAP8503
Genomic Variants (DGV)PIK3R3 [DGVbeta]
DECIPHERPIK3R3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIK3R3 
Mutations
ICGC Data PortalPIK3R3 
TCGA Data PortalPIK3R3 
Broad Tumor PortalPIK3R3
OASIS PortalPIK3R3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIK3R3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIK3R3
intOGen PortalPIK3R3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIK3R3
DgiDB (Drug Gene Interaction Database)PIK3R3
DoCM (Curated mutations)PIK3R3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIK3R3 (select a term)
intoGenPIK3R3
Cancer3DPIK3R3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606076   
Orphanet
MedgenPIK3R3
Genetic Testing Registry PIK3R3
NextProtQ92569 [Medical]
TSGene8503
GENETestsPIK3R3
Huge Navigator PIK3R3 [HugePedia]
snp3D : Map Gene to Disease8503
BioCentury BCIQPIK3R3
ClinGenPIK3R3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8503
Chemical/Pharm GKB GenePA33314
Clinical trialPIK3R3
Miscellaneous
canSAR (ICR)PIK3R3 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIK3R3
EVEXPIK3R3
GoPubMedPIK3R3
iHOPPIK3R3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:16 CEST 2017

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