PIK3R6 (phosphoinositide-3-kinase regulatory subunit 6)

2014-11-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
C17orf38,HsT41028,p84 PIKAP,p87(PIKAP),p87PIKAP

Other Information

Locus ID:

NCBI: 146850
MIM: 611462
HGNC: 27101
Ensembl: ENSG00000276231

Variants:

dbSNP: 146850
ClinVar: 146850
TCGA: ENSG00000276231
COSMIC: PIK3R6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000276231ENST00000611951A0A087X1F3
ENSG00000276231ENST00000613555A0A087X1F3
ENSG00000276231ENST00000619866Q5UE93

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Cholinergic synapseKEGGhsa04725
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164767362006Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.38
185962322008RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma.27
219967372012Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis.24
227288272012GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.17
183235252008Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells.15
240140272013p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.9
257533932015p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.2

Citation

Dessen P

PIK3R6 (phosphoinositide-3-kinase regulatory subunit 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71919/pik3r6