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PIM2 (Pim-2 proto-oncogene, serine/threonine kinase)

Identity

Alias_namespim-2 oncogene
Other alias-
HGNC (Hugo) PIM2
LocusID (NCBI) 11040
Atlas_Id 41718
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 48913182 and ends at 48919136 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PIM2 (Xp11.23) / PIM2 (Xp11.23)PIM2 (Xp11.23) / STOML2 (9p13.3)STOML2 (9p13.3) / PIM2 (Xp11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIM2   8987
Cards
Entrez_Gene (NCBI)PIM2  11040  Pim-2 proto-oncogene, serine/threonine kinase
Aliases
GeneCards (Weizmann)PIM2
Ensembl hg19 (Hinxton)ENSG00000102096 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102096 [Gene_View]  chrX:48913182-48919136 [Contig_View]  PIM2 [Vega]
ICGC DataPortalENSG00000102096
TCGA cBioPortalPIM2
AceView (NCBI)PIM2
Genatlas (Paris)PIM2
WikiGenes11040
SOURCE (Princeton)PIM2
Genetics Home Reference (NIH)PIM2
Genomic and cartography
GoldenPath hg38 (UCSC)PIM2  -     chrX:48913182-48919136 -  Xp11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIM2  -     Xp11.23   [Description]    (hg19-Feb_2009)
EnsemblPIM2 - Xp11.23 [CytoView hg19]  PIM2 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBIPIM2 [Mapview hg19]  PIM2 [Mapview hg38]
OMIM300295   
Gene and transcription
Genbank (Entrez)AK290931 AK312745 BC018111 DC378253 DQ891336
RefSeq transcript (Entrez)NM_006875
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIM2
Cluster EST : UnigeneHs.727148 [ NCBI ]
CGAP (NCI)Hs.727148
Alternative Splicing GalleryENSG00000102096
Gene ExpressionPIM2 [ NCBI-GEO ]   PIM2 [ EBI - ARRAY_EXPRESS ]   PIM2 [ SEEK ]   PIM2 [ MEM ]
Gene Expression Viewer (FireBrowse)PIM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11040
GTEX Portal (Tissue expression)PIM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P1W9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P1W9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P1W9
Splice isoforms : SwissVarQ9P1W9
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9P1W9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    PIM1/2/3    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PIM2
DMDM Disease mutations11040
Blocks (Seattle)PIM2
PDB (SRS)2IWI    4X7Q   
PDB (PDBSum)2IWI    4X7Q   
PDB (IMB)2IWI    4X7Q   
PDB (RSDB)2IWI    4X7Q   
Structural Biology KnowledgeBase2IWI    4X7Q   
SCOP (Structural Classification of Proteins)2IWI    4X7Q   
CATH (Classification of proteins structures)2IWI    4X7Q   
SuperfamilyQ9P1W9
Human Protein AtlasENSG00000102096
Peptide AtlasQ9P1W9
HPRD02244
IPIIPI00332692   IPI00647683   
Protein Interaction databases
DIP (DOE-UCLA)Q9P1W9
IntAct (EBI)Q9P1W9
FunCoupENSG00000102096
BioGRIDPIM2
STRING (EMBL)PIM2
ZODIACPIM2
Ontologies - Pathways
QuickGOQ9P1W9
Ontology : AmiGOG1/S transition of mitotic cell cycle  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  protein phosphorylation  apoptotic process  male meiotic nuclear division  regulation of mitotic cell cycle  cell proliferation  negative regulation of cell proliferation  response to virus  positive regulation of autophagy  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription, DNA-templated  protein autophosphorylation  protein stabilization  protein stabilization  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  protein phosphorylation  apoptotic process  male meiotic nuclear division  regulation of mitotic cell cycle  cell proliferation  negative regulation of cell proliferation  response to virus  positive regulation of autophagy  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription, DNA-templated  protein autophosphorylation  protein stabilization  protein stabilization  
Pathways : KEGGAcute myeloid leukemia   
NDEx NetworkPIM2
Atlas of Cancer Signalling NetworkPIM2
Wikipedia pathwaysPIM2
Orthology - Evolution
OrthoDB11040
GeneTree (enSembl)ENSG00000102096
Phylogenetic Trees/Animal Genes : TreeFamPIM2
HOVERGENQ9P1W9
HOGENOMQ9P1W9
Homologs : HomoloGenePIM2
Homology/Alignments : Family Browser (UCSC)PIM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIM2
dbVarPIM2
ClinVarPIM2
1000_GenomesPIM2 
Exome Variant ServerPIM2
ExAC (Exome Aggregation Consortium)PIM2 (select the gene name)
Genetic variants : HAPMAP11040
Genomic Variants (DGV)PIM2 [DGVbeta]
DECIPHERPIM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIM2 
Mutations
ICGC Data PortalPIM2 
TCGA Data PortalPIM2 
Broad Tumor PortalPIM2
OASIS PortalPIM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch PIM2
DgiDB (Drug Gene Interaction Database)PIM2
DoCM (Curated mutations)PIM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIM2 (select a term)
intoGenPIM2
Cancer3DPIM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300295   
Orphanet
MedgenPIM2
Genetic Testing Registry PIM2
NextProtQ9P1W9 [Medical]
TSGene11040
GENETestsPIM2
Huge Navigator PIM2 [HugePedia]
snp3D : Map Gene to Disease11040
BioCentury BCIQPIM2
ClinGenPIM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11040
Chemical/Pharm GKB GenePA33319
Clinical trialPIM2
Miscellaneous
canSAR (ICR)PIM2 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIM2
EVEXPIM2
GoPubMedPIM2
iHOPPIM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:17 CEST 2017

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