PIM3 (Pim-3 proto-oncogene, serine/threonine kinase)

2005-02-01  

Identity

HGNC
PIM3
LOCATION
22q13.33
LOCUSID
415116
ALIAS
pim-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 415116
MIM: 610580
HGNC: 19310
Ensembl: ENSG00000198355

Variants:

dbSNP: 415116
ClinVar: 415116
TCGA: ENSG00000198355
COSMIC: PIM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198355ENST00000360612Q86V86

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
185939062008Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.109
211874262011The Pim protein kinases regulate energy metabolism and cell growth.47
192660832009KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.37
241654822013A novel regulatory mechanism of Pim-3 kinase stability and its involvement in pancreatic cancer progression.21
260757202015Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts.21
216466872011The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas.17
191544092009Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.13
252382622014The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.13
247990662014PIM kinases: an overview in tumors and recent advances in pancreatic cancer.11
209398202010Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.9

Citation

Dessen P

PIM3 (Pim-3 proto-oncogene, serine/threonine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/43009/pim3