Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PIM3 (Pim-3 proto-oncogene, serine/threonine kinase)

Identity

Alias_namespim-3 oncogene
Other aliaspim-3
HGNC (Hugo) PIM3
LocusID (NCBI) 415116
Atlas_Id 43009
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 49960495 and ends at 49964072 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PIM3 (22q13.33) / ATP5G2 (12q13.13)PIM3 (22q13.33) / CRELD2 (22q13.33)PIM3 (22q13.33) / GARS (7p14.3)
PIM3 (22q13.33) / PARP9 (3q21.1)PIM3 (22q13.33) / PIM3 (22q13.33)PIM3 22q13.33 / CRELD2 22q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIM3   19310
Cards
Entrez_Gene (NCBI)PIM3  415116  Pim-3 proto-oncogene, serine/threonine kinase
Aliasespim-3
GeneCards (Weizmann)PIM3
Ensembl hg19 (Hinxton)ENSG00000198355 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198355 [Gene_View]  chr22:49960495-49964072 [Contig_View]  PIM3 [Vega]
ICGC DataPortalENSG00000198355
TCGA cBioPortalPIM3
AceView (NCBI)PIM3
Genatlas (Paris)PIM3
WikiGenes415116
SOURCE (Princeton)PIM3
Genetics Home Reference (NIH)PIM3
Genomic and cartography
GoldenPath hg38 (UCSC)PIM3  -     chr22:49960495-49964072 +  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIM3  -     22q13.33   [Description]    (hg19-Feb_2009)
EnsemblPIM3 - 22q13.33 [CytoView hg19]  PIM3 - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBIPIM3 [Mapview hg19]  PIM3 [Mapview hg38]
OMIM610580   
Gene and transcription
Genbank (Entrez)AB114795 AK292005 BC017083 BC052239 BC064477
RefSeq transcript (Entrez)NM_001001852
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIM3
Cluster EST : UnigeneHs.530381 [ NCBI ]
CGAP (NCI)Hs.530381
Alternative Splicing GalleryENSG00000198355
Gene ExpressionPIM3 [ NCBI-GEO ]   PIM3 [ EBI - ARRAY_EXPRESS ]   PIM3 [ SEEK ]   PIM3 [ MEM ]
Gene Expression Viewer (FireBrowse)PIM3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)415116
GTEX Portal (Tissue expression)PIM3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86V86   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86V86  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86V86
Splice isoforms : SwissVarQ86V86
PhosPhoSitePlusQ86V86
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    PIM1/2/3    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PIM3
DMDM Disease mutations415116
Blocks (Seattle)PIM3
SuperfamilyQ86V86
Human Protein AtlasENSG00000198355
Peptide AtlasQ86V86
HPRD15137
IPIIPI00384276   IPI00440195   
Protein Interaction databases
DIP (DOE-UCLA)Q86V86
IntAct (EBI)Q86V86
FunCoupENSG00000198355
BioGRIDPIM3
STRING (EMBL)PIM3
ZODIACPIM3
Ontologies - Pathways
QuickGOQ86V86
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  apoptotic process  cell cycle  regulation of mitotic cell cycle  negative regulation of apoptotic process  protein autophosphorylation  negative regulation of insulin secretion involved in cellular response to glucose stimulus  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  apoptotic process  cell cycle  regulation of mitotic cell cycle  negative regulation of apoptotic process  protein autophosphorylation  negative regulation of insulin secretion involved in cellular response to glucose stimulus  
NDEx NetworkPIM3
Atlas of Cancer Signalling NetworkPIM3
Wikipedia pathwaysPIM3
Orthology - Evolution
OrthoDB415116
GeneTree (enSembl)ENSG00000198355
Phylogenetic Trees/Animal Genes : TreeFamPIM3
HOVERGENQ86V86
HOGENOMQ86V86
Homologs : HomoloGenePIM3
Homology/Alignments : Family Browser (UCSC)PIM3
Gene fusions - Rearrangements
Fusion : MitelmanPIM3/CRELD2 [22q13.33/22q13.33]  
Fusion: TCGAPIM3 22q13.33 CRELD2 22q13.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIM3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIM3
dbVarPIM3
ClinVarPIM3
1000_GenomesPIM3 
Exome Variant ServerPIM3
ExAC (Exome Aggregation Consortium)PIM3 (select the gene name)
Genetic variants : HAPMAP415116
Genomic Variants (DGV)PIM3 [DGVbeta]
DECIPHERPIM3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIM3 
Mutations
ICGC Data PortalPIM3 
TCGA Data PortalPIM3 
Broad Tumor PortalPIM3
OASIS PortalPIM3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPIM3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIM3
DgiDB (Drug Gene Interaction Database)PIM3
DoCM (Curated mutations)PIM3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIM3 (select a term)
intoGenPIM3
Cancer3DPIM3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610580   
Orphanet
MedgenPIM3
Genetic Testing Registry PIM3
NextProtQ86V86 [Medical]
TSGene415116
GENETestsPIM3
Huge Navigator PIM3 [HugePedia]
snp3D : Map Gene to Disease415116
BioCentury BCIQPIM3
ClinGenPIM3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD415116
Chemical/Pharm GKB GenePA134980758
Clinical trialPIM3
Miscellaneous
canSAR (ICR)PIM3 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIM3
EVEXPIM3
GoPubMedPIM3
iHOPPIM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:31:17 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.