Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PINK1 (PTEN induced putative kinase 1)

Identity

Other namesBRPK
PARK6
HGNC (Hugo) PINK1
LocusID (NCBI) 65018
Location 1p36.12
Location_base_pair Starts at 20959948 and ends at 20978004 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PINK1   14581
Cards
Entrez_Gene (NCBI)PINK1  65018  PTEN induced putative kinase 1
GeneCards (Weizmann)PINK1
Ensembl (Hinxton)ENSG00000158828 [Gene_View]  chr1:20959948-20978004 [Contig_View]  PINK1 [Vega]
ICGC DataPortalENSG00000158828
cBioPortalPINK1
AceView (NCBI)PINK1
Genatlas (Paris)PINK1
WikiGenes65018
SOURCE (Princeton)NM_032409
Genomic and cartography
GoldenPath (UCSC)PINK1  -  1p36.12   chr1:20959948-20978004 +  1p36.12   [Description]    (hg19-Feb_2009)
EnsemblPINK1 - 1p36.12 [CytoView]
Mapping of homologs : NCBIPINK1 [Mapview]
OMIM605909   608309   
Gene and transcription
Genbank (Entrez)AB053323 AF316873 AK075225 AK130746 BC009534
RefSeq transcript (Entrez)NM_032409
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_008164 NT_032977 NW_001838573 NW_004929289
Consensus coding sequences : CCDS (NCBI)PINK1
Cluster EST : UnigeneHs.389171 [ NCBI ]
CGAP (NCI)Hs.389171
Alternative Splicing : Fast-db (Paris)GSHG0000215
Alternative Splicing GalleryENSG00000158828
Gene ExpressionPINK1 [ NCBI-GEO ]     PINK1 [ SEEK ]   PINK1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXM7 (Uniprot)
NextProtQ9BXM7  [Medical]
With graphics : InterProQ9BXM7
Splice isoforms : SwissVarQ9BXM7 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrQ9BXM7
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
DMDM Disease mutations65018
Blocks (Seattle)Q9BXM7
Human Protein AtlasENSG00000158828 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9BXM7
HPRD10514
IPIIPI00307065   IPI00411562   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXM7
IntAct (EBI)Q9BXM7
FunCoupENSG00000158828
BioGRIDPINK1
InParanoidQ9BXM7
Interologous Interaction database Q9BXM7
IntegromeDBPINK1
STRING (EMBL)PINK1
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  mitochondrion degradation  chromatin  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  mitochondrial intermembrane space  cytosol  cytoskeleton  protein phosphorylation  response to stress  cell death  calcium-dependent protein kinase activity  membrane  integral component of membrane  kinase activity  protein ubiquitination  peptidyl-serine phosphorylation  regulation of protein ubiquitination  ubiquitin protein ligase binding  positive regulation of synaptic transmission, dopaminergic  positive regulation of dopamine secretion  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein complex assembly  negative regulation of neuron apoptotic process  C3HC4-type RING finger domain binding  positive regulation of release of cytochrome c from mitochondria  cellular response to toxic substance  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
Ontology : EGO-EBImagnesium ion binding  mitochondrion degradation  chromatin  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  mitochondrial intermembrane space  cytosol  cytoskeleton  protein phosphorylation  response to stress  cell death  calcium-dependent protein kinase activity  membrane  integral component of membrane  kinase activity  protein ubiquitination  peptidyl-serine phosphorylation  regulation of protein ubiquitination  ubiquitin protein ligase binding  positive regulation of synaptic transmission, dopaminergic  positive regulation of dopamine secretion  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein complex assembly  negative regulation of neuron apoptotic process  C3HC4-type RING finger domain binding  positive regulation of release of cytochrome c from mitochondria  cellular response to toxic substance  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
Pathways : KEGGParkinson's disease   
Protein Interaction DatabasePINK1
Wikipedia pathwaysPINK1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PINK1
snp3D : Map Gene to Disease65018
SNP (GeneSNP Utah)PINK1
SNP : HGBasePINK1
Genetic variants : HAPMAPPINK1
Exome VariantPINK1
1000_GenomesPINK1 
ICGC programENSG00000158828 
Somatic Mutations in Cancer : COSMICPINK1 
CONAN: Copy Number AnalysisPINK1 
Mutations and Diseases : HGMDPINK1
Mutations and Diseases : intOGenPINK1
Genomic VariantsPINK1  PINK1 [DGVbeta]
dbVarPINK1
ClinVarPINK1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM605909    608309   
MedgenPINK1
GENETestsPINK1
Disease Genetic AssociationPINK1
Huge Navigator PINK1 [HugePedia]  PINK1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePINK1
Homology/Alignments : Family Browser (UCSC)PINK1
Phylogenetic Trees/Animal Genes : TreeFamPINK1
Chemical/Protein Interactions : CTD65018
Chemical/Pharm GKB GenePA33325
Clinical trialPINK1
Cancer Resource (Charite)ENSG00000158828
Other databases
Probes
Litterature
PubMed223 Pubmed reference(s) in Entrez
CoreMinePINK1
iHOPPINK1
OncoSearchPINK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:59:46 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.