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PINK1 (PTEN induced putative kinase 1)

Identity

Other namesBRPK
PARK6
HGNC (Hugo) PINK1
LocusID (NCBI) 65018
Location 1p36.12
Location_base_pair Starts at 20959948 and ends at 20978004 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PINK1   14581
Cards
Entrez_Gene (NCBI)PINK1  65018  PTEN induced putative kinase 1
GeneCards (Weizmann)PINK1
Ensembl (Hinxton)ENSG00000158828 [Gene_View]  chr1:20959948-20978004 [Contig_View]  PINK1 [Vega]
AceView (NCBI)PINK1
Genatlas (Paris)PINK1
WikiGenes65018
SOURCE (Princeton)NM_032409
Genomic and cartography
GoldenPath (UCSC)PINK1  -  1p36.12   chr1:20959948-20978004 +  1p36.12   [Description]    (hg19-Feb_2009)
EnsemblPINK1 - 1p36.12 [CytoView]
Mapping of homologs : NCBIPINK1 [Mapview]
OMIM605909   608309   
Gene and transcription
Genbank (Entrez)AB053323 AF316873 AK075225 AK130746 BC009534
RefSeq transcript (Entrez)NM_032409
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_008164 NT_004610 NW_001838573 NW_004929289
Consensus coding sequences : CCDS (NCBI)PINK1
Cluster EST : UnigeneHs.389171 [ NCBI ]
CGAP (NCI)Hs.389171
Alternative Splicing : Fast-db (Paris)GSHG0000215
Alternative Splicing GalleryENSG00000158828
Gene ExpressionPINK1 [ NCBI-GEO ]     PINK1 [ SEEK ]   PINK1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXM7 (Uniprot)
NextProtQ9BXM7  [Medical]
With graphics : InterProQ9BXM7
Splice isoforms : SwissVarQ9BXM7 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ9BXM7
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
DMDM Disease mutations65018
Blocks (Seattle)Q9BXM7
Human Protein AtlasENSG00000158828
Peptide AtlasQ9BXM7
HPRD10514
IPIIPI00307065   IPI00411562   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXM7
IntAct (EBI)Q9BXM7
FunCoupENSG00000158828
BioGRIDPINK1
InParanoidQ9BXM7
Interologous Interaction database Q9BXM7
IntegromeDBPINK1
STRING (EMBL)PINK1
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  mitochondrion degradation  protein serine/threonine kinase activity  protein binding  ATP binding  mitochondrion  mitochondrial outer membrane  cytosol  protein phosphorylation  response to stress  intracellular protein kinase cascade  cell death  calcium-dependent protein kinase activity  integral to membrane  kinase activity  peptidyl-serine phosphorylation  regulation of protein ubiquitination  ubiquitin protein ligase binding  positive regulation of synaptic transmission, dopaminergic  positive regulation of dopamine secretion  positive regulation of I-kappaB kinase/NF-kappaB cascade  regulation of protein complex assembly  negative regulation of neuron apoptotic process  C3HC4-type RING finger domain binding  positive regulation of release of cytochrome c from mitochondria  cellular response to toxic substance  
Ontology : EGO-EBImagnesium ion binding  mitochondrion degradation  protein serine/threonine kinase activity  protein binding  ATP binding  mitochondrion  mitochondrial outer membrane  cytosol  protein phosphorylation  response to stress  intracellular protein kinase cascade  cell death  calcium-dependent protein kinase activity  integral to membrane  kinase activity  peptidyl-serine phosphorylation  regulation of protein ubiquitination  ubiquitin protein ligase binding  positive regulation of synaptic transmission, dopaminergic  positive regulation of dopamine secretion  positive regulation of I-kappaB kinase/NF-kappaB cascade  regulation of protein complex assembly  negative regulation of neuron apoptotic process  C3HC4-type RING finger domain binding  positive regulation of release of cytochrome c from mitochondria  cellular response to toxic substance  
Pathways : KEGGParkinson's disease   
REACTOMEPINK1
Protein Interaction DatabasePINK1
Wikipedia pathwaysPINK1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PINK1
SNP (GeneSNP Utah)PINK1
SNP : HGBasePINK1
Genetic variants : HAPMAPPINK1
1000_GenomesPINK1 
ICGC programENSG00000158828 
Somatic Mutations in Cancer : COSMICPINK1 
CONAN: Copy Number AnalysisPINK1 
Mutations and Diseases : HGMDPINK1
OMIM605909    608309   
GENETestsPINK1
Disease Genetic AssociationPINK1
Huge Navigator PINK1 [HugePedia]  PINK1 [HugeCancerGEM]
Genomic VariantsPINK1  PINK1 [DGVbeta]
Exome VariantPINK1
dbVarPINK1
ClinVarPINK1
snp3D : Map Gene to Disease65018
General knowledge
Homologs : HomoloGenePINK1
Homology/Alignments : Family Browser (UCSC)PINK1
Phylogenetic Trees/Animal Genes : TreeFamPINK1
Chemical/Protein Interactions : CTD65018
Chemical/Pharm GKB GenePA33325
Clinical trialPINK1
Cancer Resource (Charite)ENSG00000158828
Other databases
Probes
Litterature
PubMed203 Pubmed reference(s) in Entrez
CoreMinePINK1
iHOPPINK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:45:42 CEST 2014

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