PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1)

2003-02-01  

Identity

HGNC
PINX1
LOCATION
8p23.1
LOCUSID
54984
ALIAS
Gno1,LPTL,LPTS,Pxr1

Other Information

Locus ID:

NCBI: 54984
MIM: 606505
HGNC: 30046
Ensembl: ENSG00000254093

Variants:

dbSNP: 54984
ClinVar: 54984
TCGA: ENSG00000254093
COSMIC: PINX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000254093ENST00000314787Q96BK5
ENSG00000254093ENST00000519088Q96BK5
ENSG00000254093ENST00000523559E5RJG9
ENSG00000254093ENST00000524061H0YBF0
ENSG00000254093ENST00000524114E5RGR1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203676402010Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.44
121071832002The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition.31
200566412010Multiple genetic variants in telomere pathway genes and breast cancer risk.24
191179892009Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.22
153817002004Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.19
195536602009PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.18
248237962014The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis.17
258888292015PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway.16
211191972011Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.15

Citation

Dessen P

PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41721/pinx1