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PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta)

Identity

Alias_namesPIP5K2B
phosphatidylinositol-4-phosphate 5-kinase, type II, beta
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Alias_symbol (synonym)PIP5KIIB
PIP5KIIbeta
Other aliasPI5P4KB
PIP5P4KB
HGNC (Hugo) PIP4K2B
LocusID (NCBI) 8396
Atlas_Id 46799
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 36921944 and ends at 36956158 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BPTF (17q24.2) / PIP4K2B (17q12)C7orf50 (7p22.3) / PIP4K2B (17q12)CDC20 (1p34.2) / PIP4K2B (17q12)
PIP4K2B (17q12) / APBA3 (19p13.3)PIP4K2B (17q12) / DGCR5 (22q11.21)PIP4K2B (17q12) / MED24 (17q21.1)
PIP4K2B (17q12) / PIP4K2B (17q12)PIP4K2B (17q12) / SLC6A4 (17q11.2)PIP4K2B (17q12) / TMEM132E (17q12)
PIP4K2B (17q12) / TMEM99 (17q21.2)BPTF 17q24.2 / PIP4K2B 17q12PIP4K2B 17q12 / MED24 17q21.1
PIP4K2B 17q12 / SLC6A4 17q11.2PIP4K2B 17q12 / TMEM132E 17q12PIP4K2B 17q12 / TMEM99 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIP4K2B   8998
Cards
Entrez_Gene (NCBI)PIP4K2B  8396  phosphatidylinositol-5-phosphate 4-kinase type 2 beta
AliasesPI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta; 
PIP5P4KB
GeneCards (Weizmann)PIP4K2B
Ensembl hg19 (Hinxton)ENSG00000276293 [Gene_View]  chr17:36921944-36956158 [Contig_View]  PIP4K2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000276293 [Gene_View]  chr17:36921944-36956158 [Contig_View]  PIP4K2B [Vega]
ICGC DataPortalENSG00000276293
TCGA cBioPortalPIP4K2B
AceView (NCBI)PIP4K2B
Genatlas (Paris)PIP4K2B
WikiGenes8396
SOURCE (Princeton)PIP4K2B
Genetics Home Reference (NIH)PIP4K2B
Genomic and cartography
GoldenPath hg19 (UCSC)PIP4K2B  -     chr17:36921944-36956158 -  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PIP4K2B  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblPIP4K2B - 17q12 [CytoView hg19]  PIP4K2B - 17q12 [CytoView hg38]
Mapping of homologs : NCBIPIP4K2B [Mapview hg19]  PIP4K2B [Mapview hg38]
OMIM603261   
Gene and transcription
Genbank (Entrez)AI333549 AK307169 BC027459 BC073896 BC094858
RefSeq transcript (Entrez)NM_003559 NM_138687
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NT_187614 NW_004929407
Consensus coding sequences : CCDS (NCBI)PIP4K2B
Cluster EST : UnigeneHs.260603 [ NCBI ]
CGAP (NCI)Hs.260603
Alternative Splicing GalleryENSG00000276293
Gene ExpressionPIP4K2B [ NCBI-GEO ]   PIP4K2B [ EBI - ARRAY_EXPRESS ]   PIP4K2B [ SEEK ]   PIP4K2B [ MEM ]
Gene Expression Viewer (FireBrowse)PIP4K2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8396
GTEX Portal (Tissue expression)PIP4K2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78356   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78356  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78356
Splice isoforms : SwissVarP78356
Catalytic activity : Enzyme2.7.1.149 [ Enzyme-Expasy ]   2.7.1.1492.7.1.149 [ IntEnz-EBI ]   2.7.1.149 [ BRENDA ]   2.7.1.149 [ KEGG ]   
PhosPhoSitePlusP78356
Domaine pattern : Prosite (Expaxy)PIPK (PS51455)   
Domains : Interpro (EBI)PInositol-4-P-5-kinase    PInositol-4-P-5-kinase_C    PInositol-4-P-5-kinase_core    PInositol-4-P-5-kinase_N    PInositol-4P-5-kinase_core_sub   
Domain families : Pfam (Sanger)PIP5K (PF01504)   
Domain families : Pfam (NCBI)pfam01504   
Domain families : Smart (EMBL)PIPKc (SM00330)  
Conserved Domain (NCBI)PIP4K2B
DMDM Disease mutations8396
Blocks (Seattle)PIP4K2B
PDB (SRS)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C   
PDB (PDBSum)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C   
PDB (IMB)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C   
PDB (RSDB)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C   
Structural Biology KnowledgeBase1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C   
SCOP (Structural Classification of Proteins)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C   
CATH (Classification of proteins structures)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C   
SuperfamilyP78356
Human Protein AtlasENSG00000276293
Peptide AtlasP78356
HPRD04463
IPIIPI00216470   IPI00235352   IPI00952795   
Protein Interaction databases
DIP (DOE-UCLA)P78356
IntAct (EBI)P78356
FunCoupENSG00000276293
BioGRIDPIP4K2B
STRING (EMBL)PIP4K2B
ZODIACPIP4K2B
Ontologies - Pathways
QuickGOP78356
Ontology : AmiGOreceptor signaling protein activity  protein binding  ATP binding  nucleoplasm  autophagosome  endoplasmic reticulum membrane  cytosol  plasma membrane  phosphatidylinositol biosynthetic process  cell surface receptor signaling pathway  regulation of autophagy  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-4-phosphate 5-kinase activity  1-phosphatidylinositol-5-phosphate 4-kinase activity  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  1-phosphatidylinositol-3-phosphate 4-kinase activity  positive regulation of autophagosome assembly  
Ontology : EGO-EBIreceptor signaling protein activity  protein binding  ATP binding  nucleoplasm  autophagosome  endoplasmic reticulum membrane  cytosol  plasma membrane  phosphatidylinositol biosynthetic process  cell surface receptor signaling pathway  regulation of autophagy  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-4-phosphate 5-kinase activity  1-phosphatidylinositol-5-phosphate 4-kinase activity  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  phosphatidylinositol phosphorylation  1-phosphatidylinositol-3-phosphate 4-kinase activity  positive regulation of autophagosome assembly  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    Regulation of actin cytoskeleton   
NDEx NetworkPIP4K2B
Atlas of Cancer Signalling NetworkPIP4K2B
Wikipedia pathwaysPIP4K2B
Orthology - Evolution
OrthoDB8396
GeneTree (enSembl)ENSG00000276293
Phylogenetic Trees/Animal Genes : TreeFamPIP4K2B
HOVERGENP78356
HOGENOMP78356
Homologs : HomoloGenePIP4K2B
Homology/Alignments : Family Browser (UCSC)PIP4K2B
Gene fusions - Rearrangements
Fusion : MitelmanBPTF/PIP4K2B [17q24.2/17q12]  [t(17;17)(q12;q24)]  
Fusion : MitelmanPIP4K2B/MED24 [17q12/17q21.1]  [t(17;17)(q12;q21)]  
Fusion : MitelmanPIP4K2B/SLC6A4 [17q12/17q11.2]  [t(17;17)(q11;q12)]  
Fusion : MitelmanPIP4K2B/TMEM99 [17q12/17q21.2]  [t(17;17)(q12;q21)]  
Fusion: TCGABPTF 17q24.2 PIP4K2B 17q12 BRCA
Fusion: TCGAPIP4K2B 17q12 MED24 17q21.1 BRCA
Fusion: TCGAPIP4K2B 17q12 SLC6A4 17q11.2 BRCA
Fusion: TCGAPIP4K2B 17q12 TMEM132E 17q12 BRCA
Fusion: TCGAPIP4K2B 17q12 TMEM99 17q21.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIP4K2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIP4K2B
dbVarPIP4K2B
ClinVarPIP4K2B
1000_GenomesPIP4K2B 
Exome Variant ServerPIP4K2B
ExAC (Exome Aggregation Consortium)PIP4K2B (select the gene name)
Genetic variants : HAPMAP8396
Genomic Variants (DGV)PIP4K2B [DGVbeta]
DECIPHER (Syndromes)17:36921944-36956158  ENSG00000276293
CONAN: Copy Number AnalysisPIP4K2B 
Mutations
ICGC Data PortalPIP4K2B 
TCGA Data PortalPIP4K2B 
Broad Tumor PortalPIP4K2B
OASIS PortalPIP4K2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIP4K2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIP4K2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIP4K2B
DgiDB (Drug Gene Interaction Database)PIP4K2B
DoCM (Curated mutations)PIP4K2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIP4K2B (select a term)
intoGenPIP4K2B
Cancer3DPIP4K2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603261   
Orphanet
MedgenPIP4K2B
Genetic Testing Registry PIP4K2B
NextProtP78356 [Medical]
TSGene8396
GENETestsPIP4K2B
Huge Navigator PIP4K2B [HugePedia]
snp3D : Map Gene to Disease8396
BioCentury BCIQPIP4K2B
ClinGenPIP4K2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8396
Chemical/Pharm GKB GenePA162399640
Clinical trialPIP4K2B
Miscellaneous
canSAR (ICR)PIP4K2B (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIP4K2B
EVEXPIP4K2B
GoPubMedPIP4K2B
iHOPPIP4K2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:26 CEST 2017

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