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PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta)

Identity

Alias (NCBI)PI5P4KB
PIP5K2B
PIP5KIIB
PIP5KIIbeta
PIP5P4KB
HGNC (Hugo) PIP4K2B
HGNC Alias symbPIP5KIIB
PIP5KIIbeta
HGNC Previous namePIP5K2B
HGNC Previous namephosphatidylinositol-4-phosphate 5-kinase, type II, beta
 phosphatidylinositol-5-phosphate 4-kinase, type II, beta
LocusID (NCBI) 8396
Atlas_Id 46799
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 38765691 and ends at 38799905 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BPTF (17q24.2) / PIP4K2B (17q12)C7orf50 (7p22.3) / PIP4K2B (17q12)CDC20 (1p34.2) / PIP4K2B (17q12)
PIP4K2B (17q12) / APBA3 (19p13.3)PIP4K2B (17q12) / DGCR5 (22q11.21)PIP4K2B (17q12) / MED24 (17q21.1)
PIP4K2B (17q12) / PIP4K2B (17q12)PIP4K2B (17q12) / SLC6A4 (17q11.2)PIP4K2B (17q12) / TMEM132E (17q12)
PIP4K2B (17q12) / TMEM99 (17q21.2)BPTF 17q24.2 / PIP4K2B 17q12PIP4K2B 17q12 / MED24 17q21.1
PIP4K2B 17q12 / SLC6A4 17q11.2PIP4K2B 17q12 / TMEM132E 17q12PIP4K2B 17q12 / TMEM99 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PIP4K2B   8998
Cards
Entrez_Gene (NCBI)PIP4K2B    phosphatidylinositol-5-phosphate 4-kinase type 2 beta
AliasesPI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta; 
PIP5P4KB
GeneCards (Weizmann)PIP4K2B
Ensembl hg19 (Hinxton)ENSG00000276293 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000276293 [Gene_View]  ENSG00000276293 [Sequence]  chr17:38765691-38799905 [Contig_View]  PIP4K2B [Vega]
ICGC DataPortalENSG00000276293
TCGA cBioPortalPIP4K2B
AceView (NCBI)PIP4K2B
Genatlas (Paris)PIP4K2B
SOURCE (Princeton)PIP4K2B
Genetics Home Reference (NIH)PIP4K2B
Genomic and cartography
GoldenPath hg38 (UCSC)PIP4K2B  -     chr17:38765691-38799905 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIP4K2B  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathPIP4K2B - 17q12 [CytoView hg19]  PIP4K2B - 17q12 [CytoView hg38]
ImmunoBaseENSG00000276293
Genome Data Viewer NCBIPIP4K2B [Mapview hg19]  
OMIM603261   
Gene and transcription
Genbank (Entrez)AI333549 AK307169 BC027459 BC073896 BC094858
RefSeq transcript (Entrez)NM_003559 NM_138687
Consensus coding sequences : CCDS (NCBI)PIP4K2B
Gene ExpressionPIP4K2B [ NCBI-GEO ]   PIP4K2B [ EBI - ARRAY_EXPRESS ]   PIP4K2B [ SEEK ]   PIP4K2B [ MEM ]
Gene Expression Viewer (FireBrowse)PIP4K2B [ Firebrowse - Broad ]
GenevisibleExpression of PIP4K2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8396
GTEX Portal (Tissue expression)PIP4K2B
Human Protein AtlasENSG00000276293-PIP4K2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78356   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78356  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78356
PhosPhoSitePlusP78356
Domaine pattern : Prosite (Expaxy)PIPK (PS51455)   
Domains : Interpro (EBI)PInositol-4-P-5-kinase    PInositol-4-P-5-kinase_C    PInositol-4-P-5-kinase_core    PInositol-4-P-5-kinase_N   
Domain families : Pfam (Sanger)PIP5K (PF01504)   
Domain families : Pfam (NCBI)pfam01504   
Domain families : Smart (EMBL)PIPKc (SM00330)  
Conserved Domain (NCBI)PIP4K2B
PDB (RSDB)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C    6K4G    6K4H   
PDB Europe1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C    6K4G    6K4H   
PDB (PDBSum)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C    6K4G    6K4H   
PDB (IMB)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C    6K4G    6K4H   
Structural Biology KnowledgeBase1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C    6K4G    6K4H   
SCOP (Structural Classification of Proteins)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C    6K4G    6K4H   
CATH (Classification of proteins structures)1BO1    3WZZ    3X01    3X02    3X03    3X04    3X05    3X06    3X07    3X08    3X09    3X0A    3X0B    3X0C    6K4G    6K4H   
SuperfamilyP78356
AlphaFold pdb e-kbP78356   
Human Protein Atlas [tissue]ENSG00000276293-PIP4K2B [tissue]
HPRD04463
Protein Interaction databases
DIP (DOE-UCLA)P78356
IntAct (EBI)P78356
BioGRIDPIP4K2B
STRING (EMBL)PIP4K2B
ZODIACPIP4K2B
Ontologies - Pathways
QuickGOP78356
Ontology : AmiGOprotein binding  ATP binding  GTP binding  nucleus  nucleoplasm  nucleoplasm  autophagosome  endoplasmic reticulum membrane  cytosol  plasma membrane  phospholipid metabolic process  phosphatidylinositol biosynthetic process  cell surface receptor signaling pathway  regulation of autophagy  regulation of autophagy  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-4-phosphate 5-kinase activity  1-phosphatidylinositol-5-phosphate 4-kinase activity  phosphorylation  protein homodimerization activity  negative regulation of insulin receptor signaling pathway  autophagosome-lysosome fusion  negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity  regulation of signal transduction by p53 class mediator  1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process  positive regulation of autophagosome assembly  
Ontology : EGO-EBIprotein binding  ATP binding  GTP binding  nucleus  nucleoplasm  nucleoplasm  autophagosome  endoplasmic reticulum membrane  cytosol  plasma membrane  phospholipid metabolic process  phosphatidylinositol biosynthetic process  cell surface receptor signaling pathway  regulation of autophagy  regulation of autophagy  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-4-phosphate 5-kinase activity  1-phosphatidylinositol-5-phosphate 4-kinase activity  phosphorylation  protein homodimerization activity  negative regulation of insulin receptor signaling pathway  autophagosome-lysosome fusion  negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity  regulation of signal transduction by p53 class mediator  1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process  positive regulation of autophagosome assembly  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    Regulation of actin cytoskeleton   
NDEx NetworkPIP4K2B
Atlas of Cancer Signalling NetworkPIP4K2B
Wikipedia pathwaysPIP4K2B
Orthology - Evolution
OrthoDB8396
GeneTree (enSembl)ENSG00000276293
Phylogenetic Trees/Animal Genes : TreeFamPIP4K2B
Homologs : HomoloGenePIP4K2B
Homology/Alignments : Family Browser (UCSC)PIP4K2B
Gene fusions - Rearrangements
Fusion : MitelmanBPTF/PIP4K2B [17q24.2/17q12]  
Fusion : MitelmanPIP4K2B/MED24 [17q12/17q21.1]  
Fusion : MitelmanPIP4K2B/SLC6A4 [17q12/17q11.2]  
Fusion : MitelmanPIP4K2B/TMEM99 [17q12/17q21.2]  
Fusion : QuiverPIP4K2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIP4K2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIP4K2B
dbVarPIP4K2B
ClinVarPIP4K2B
MonarchPIP4K2B
1000_GenomesPIP4K2B 
Exome Variant ServerPIP4K2B
GNOMAD BrowserENSG00000276293
Varsome BrowserPIP4K2B
ACMGPIP4K2B variants
VarityP78356
Genomic Variants (DGV)PIP4K2B [DGVbeta]
DECIPHERPIP4K2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIP4K2B 
Mutations
ICGC Data PortalPIP4K2B 
TCGA Data PortalPIP4K2B 
Broad Tumor PortalPIP4K2B
OASIS PortalPIP4K2B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPIP4K2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPIP4K2B
DgiDB (Drug Gene Interaction Database)PIP4K2B
DoCM (Curated mutations)PIP4K2B
CIViC (Clinical Interpretations of Variants in Cancer)PIP4K2B
Cancer3DPIP4K2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603261   
Orphanet
DisGeNETPIP4K2B
MedgenPIP4K2B
Genetic Testing Registry PIP4K2B
NextProtP78356 [Medical]
GENETestsPIP4K2B
Target ValidationPIP4K2B
Huge Navigator PIP4K2B [HugePedia]
ClinGenPIP4K2B
Clinical trials, drugs, therapy
MyCancerGenomePIP4K2B
Protein Interactions : CTDPIP4K2B
Pharm GKB GenePA162399640
PharosP78356
Clinical trialPIP4K2B
Miscellaneous
canSAR (ICR)PIP4K2B
HarmonizomePIP4K2B
DataMed IndexPIP4K2B
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIP4K2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:23 CEST 2021

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