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PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta)

Identity

Alias_namesphosphatidylinositol-4-phosphate 5-kinase
Alias_symbol (synonym)STM7
MSS4
Other alias
HGNC (Hugo) PIP5K1B
LocusID (NCBI) 8395
Atlas_Id 47416
Location 9q21.11  [Link to chromosome band 9q21]
Location_base_pair Starts at 68705414 and ends at 69009176 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNKSR2 (Xp22.12) / PIP5K1B (9q21.11)PIP5K1B (9q21.11) / ABHD15 (17q11.2)PIP5K1B (9q21.11) / PGM5 (9q21.11)
STK24 (13q32.2) / PIP5K1B (9q21.11)ZNF37A (10p11.1) / PIP5K1B (9q21.11)PIP5K1B 9q21.11 / PGM5 9q21.11
STK24 13q32.2 / PIP5K1B 9q21.11ZNF37A 10p11.1 / PIP5K1B 9q21.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIP5K1B   8995
Cards
Entrez_Gene (NCBI)PIP5K1B  8395  phosphatidylinositol-4-phosphate 5-kinase type 1 beta
AliasesMSS4; STM7
GeneCards (Weizmann)PIP5K1B
Ensembl hg19 (Hinxton)ENSG00000107242 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107242 [Gene_View]  chr9:68705414-69009176 [Contig_View]  PIP5K1B [Vega]
ICGC DataPortalENSG00000107242
TCGA cBioPortalPIP5K1B
AceView (NCBI)PIP5K1B
Genatlas (Paris)PIP5K1B
WikiGenes8395
SOURCE (Princeton)PIP5K1B
Genetics Home Reference (NIH)PIP5K1B
Genomic and cartography
GoldenPath hg38 (UCSC)PIP5K1B  -     chr9:68705414-69009176 +  9q21.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIP5K1B  -     9q21.11   [Description]    (hg19-Feb_2009)
EnsemblPIP5K1B - 9q21.11 [CytoView hg19]  PIP5K1B - 9q21.11 [CytoView hg38]
Mapping of homologs : NCBIPIP5K1B [Mapview hg19]  PIP5K1B [Mapview hg38]
OMIM602745   
Gene and transcription
Genbank (Entrez)AK292734 AK295587 BC030587 CB988216 CK299479
RefSeq transcript (Entrez)NM_001031687 NM_001278253 NM_003558
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIP5K1B
Cluster EST : UnigeneHs.534371 [ NCBI ]
CGAP (NCI)Hs.534371
Alternative Splicing GalleryENSG00000107242
Gene ExpressionPIP5K1B [ NCBI-GEO ]   PIP5K1B [ EBI - ARRAY_EXPRESS ]   PIP5K1B [ SEEK ]   PIP5K1B [ MEM ]
Gene Expression Viewer (FireBrowse)PIP5K1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8395
GTEX Portal (Tissue expression)PIP5K1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14986   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14986  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14986
Splice isoforms : SwissVarO14986
Catalytic activity : Enzyme2.7.1.68 [ Enzyme-Expasy ]   2.7.1.682.7.1.68 [ IntEnz-EBI ]   2.7.1.68 [ BRENDA ]   2.7.1.68 [ KEGG ]   
PhosPhoSitePlusO14986
Domaine pattern : Prosite (Expaxy)PIPK (PS51455)   
Domains : Interpro (EBI)PInositol-4-P-5-kinase    PInositol-4-P-5-kinase_C    PInositol-4-P-5-kinase_core    PInositol-4-P-5-kinase_N   
Domain families : Pfam (Sanger)PIP5K (PF01504)   
Domain families : Pfam (NCBI)pfam01504   
Domain families : Smart (EMBL)PIPKc (SM00330)  
Conserved Domain (NCBI)PIP5K1B
DMDM Disease mutations8395
Blocks (Seattle)PIP5K1B
SuperfamilyO14986
Human Protein AtlasENSG00000107242
Peptide AtlasO14986
HPRD04121
IPIIPI00465236   IPI00304025   IPI00645719   IPI00844583   IPI00646827   IPI00645354   
Protein Interaction databases
DIP (DOE-UCLA)O14986
IntAct (EBI)O14986
FunCoupENSG00000107242
BioGRIDPIP5K1B
STRING (EMBL)PIP5K1B
ZODIACPIP5K1B
Ontologies - Pathways
QuickGOO14986
Ontology : AmiGO1-phosphatidylinositol-3-phosphate 5-kinase activity  uropod  protein binding  ATP binding  cytosol  phosphatidylinositol biosynthetic process  endomembrane system  regulation of phosphatidylinositol 3-kinase signaling  membrane  1-phosphatidylinositol-4-phosphate 5-kinase activity  1-phosphatidylinositol-4-phosphate 5-kinase activity  phosphatidylinositol phosphorylation  1-phosphatidylinositol-5-kinase activity  1-phosphatidylinositol-3-phosphate 4-kinase activity  phosphatidylinositol-3,4-bisphosphate 5-kinase activity  
Ontology : EGO-EBI1-phosphatidylinositol-3-phosphate 5-kinase activity  uropod  protein binding  ATP binding  cytosol  phosphatidylinositol biosynthetic process  endomembrane system  regulation of phosphatidylinositol 3-kinase signaling  membrane  1-phosphatidylinositol-4-phosphate 5-kinase activity  1-phosphatidylinositol-4-phosphate 5-kinase activity  phosphatidylinositol phosphorylation  1-phosphatidylinositol-5-kinase activity  1-phosphatidylinositol-3-phosphate 4-kinase activity  phosphatidylinositol-3,4-bisphosphate 5-kinase activity  
Pathways : BIOCARTARho cell motility signaling pathway [Genes]   
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    Endocytosis    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton   
NDEx NetworkPIP5K1B
Atlas of Cancer Signalling NetworkPIP5K1B
Wikipedia pathwaysPIP5K1B
Orthology - Evolution
OrthoDB8395
GeneTree (enSembl)ENSG00000107242
Phylogenetic Trees/Animal Genes : TreeFamPIP5K1B
HOVERGENO14986
HOGENOMO14986
Homologs : HomoloGenePIP5K1B
Homology/Alignments : Family Browser (UCSC)PIP5K1B
Gene fusions - Rearrangements
Fusion : MitelmanPIP5K1B/PGM5 [9q21.11/9q21.11]  
Fusion : MitelmanSTK24/PIP5K1B [13q32.2/9q21.11]  [t(9;13)(q21;q32)]  
Fusion : MitelmanZNF37A/PIP5K1B [10p11.1/9q21.11]  [t(9;10)(q21;p11)]  
Fusion: TCGAPIP5K1B 9q21.11 PGM5 9q21.11 BRCA
Fusion: TCGASTK24 13q32.2 PIP5K1B 9q21.11 BRCA
Fusion: TCGAZNF37A 10p11.1 PIP5K1B 9q21.11 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIP5K1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIP5K1B
dbVarPIP5K1B
ClinVarPIP5K1B
1000_GenomesPIP5K1B 
Exome Variant ServerPIP5K1B
ExAC (Exome Aggregation Consortium)PIP5K1B (select the gene name)
Genetic variants : HAPMAP8395
Genomic Variants (DGV)PIP5K1B [DGVbeta]
DECIPHERPIP5K1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIP5K1B 
Mutations
ICGC Data PortalPIP5K1B 
TCGA Data PortalPIP5K1B 
Broad Tumor PortalPIP5K1B
OASIS PortalPIP5K1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIP5K1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIP5K1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIP5K1B
DgiDB (Drug Gene Interaction Database)PIP5K1B
DoCM (Curated mutations)PIP5K1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIP5K1B (select a term)
intoGenPIP5K1B
Cancer3DPIP5K1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602745   
Orphanet
MedgenPIP5K1B
Genetic Testing Registry PIP5K1B
NextProtO14986 [Medical]
TSGene8395
GENETestsPIP5K1B
Huge Navigator PIP5K1B [HugePedia]
snp3D : Map Gene to Disease8395
BioCentury BCIQPIP5K1B
ClinGenPIP5K1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8395
Chemical/Pharm GKB GenePA33328
Clinical trialPIP5K1B
Miscellaneous
canSAR (ICR)PIP5K1B (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIP5K1B
EVEXPIP5K1B
GoPubMedPIP5K1B
iHOPPIP5K1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:19 CEST 2017

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