Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PIR (pirin)

Identity

Alias (NCBI)-
HGNC (Hugo) PIR
HGNC Previous namepirin (iron-binding nuclear protein)
LocusID (NCBI) 8544
Atlas_Id 41722
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 15384801 and ends at 15493588 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;17)(q24;q22) ???BCL3/MYC


External links

Nomenclature
HGNC (Hugo)PIR   30048
Cards
Entrez_Gene (NCBI)PIR    pirin
Aliases
GeneCards (Weizmann)PIR
Ensembl hg19 (Hinxton)ENSG00000087842 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087842 [Gene_View]  ENSG00000087842 [Sequence]  chrX:15384801-15493588 [Contig_View]  PIR [Vega]
ICGC DataPortalENSG00000087842
TCGA cBioPortalPIR
AceView (NCBI)PIR
Genatlas (Paris)PIR
SOURCE (Princeton)PIR
Genetics Home Reference (NIH)PIR
Genomic and cartography
GoldenPath hg38 (UCSC)PIR  -     chrX:15384801-15493588 -  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIR  -     Xp22.2   [Description]    (hg19-Feb_2009)
GoldenPathPIR - Xp22.2 [CytoView hg19]  PIR - Xp22.2 [CytoView hg38]
ImmunoBaseENSG00000087842
genome Data Viewer NCBIPIR [Mapview hg19]  
OMIM300931   
Gene and transcription
Genbank (Entrez)AK309656 BC002517 BT019583 BT019584 CR541822
RefSeq transcript (Entrez)NM_001018109 NM_003662
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PIR
Alternative Splicing GalleryENSG00000087842
Gene ExpressionPIR [ NCBI-GEO ]   PIR [ EBI - ARRAY_EXPRESS ]   PIR [ SEEK ]   PIR [ MEM ]
Gene Expression Viewer (FireBrowse)PIR [ Firebrowse - Broad ]
GenevisibleExpression of PIR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8544
GTEX Portal (Tissue expression)PIR
Human Protein AtlasENSG00000087842-PIR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00625   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00625  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00625
Splice isoforms : SwissVarO00625
Catalytic activity : Enzyme1.13.11.24 [ Enzyme-Expasy ]   1.13.11.241.13.11.24 [ IntEnz-EBI ]   1.13.11.24 [ BRENDA ]   1.13.11.24 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO00625
Domains : Interpro (EBI)Pirin    Pirin_C_dom    Pirin_N_dom    RmlC-like_jellyroll    RmlC_Cupin_sf   
Domain families : Pfam (Sanger)Pirin (PF02678)    Pirin_C (PF05726)   
Domain families : Pfam (NCBI)pfam02678    pfam05726   
Conserved Domain (NCBI)PIR
Blocks (Seattle)PIR
PDB (RSDB)1J1L    3ACL    4ERO    4EWA    4EWD    4EWE    4GUL    4HLT    5JCT    6H1H    6H1I    6N0J    6N0K   
PDB Europe1J1L    3ACL    4ERO    4EWA    4EWD    4EWE    4GUL    4HLT    5JCT    6H1H    6H1I    6N0J    6N0K   
PDB (PDBSum)1J1L    3ACL    4ERO    4EWA    4EWD    4EWE    4GUL    4HLT    5JCT    6H1H    6H1I    6N0J    6N0K   
PDB (IMB)1J1L    3ACL    4ERO    4EWA    4EWD    4EWE    4GUL    4HLT    5JCT    6H1H    6H1I    6N0J    6N0K   
Structural Biology KnowledgeBase1J1L    3ACL    4ERO    4EWA    4EWD    4EWE    4GUL    4HLT    5JCT    6H1H    6H1I    6N0J    6N0K   
SCOP (Structural Classification of Proteins)1J1L    3ACL    4ERO    4EWA    4EWD    4EWE    4GUL    4HLT    5JCT    6H1H    6H1I    6N0J    6N0K   
CATH (Classification of proteins structures)1J1L    3ACL    4ERO    4EWA    4EWD    4EWE    4GUL    4HLT    5JCT    6H1H    6H1I    6N0J    6N0K   
SuperfamilyO00625
Human Protein Atlas [tissue]ENSG00000087842-PIR [tissue]
Peptide AtlasO00625
HPRD04510
IPIIPI00012575   
Protein Interaction databases
DIP (DOE-UCLA)O00625
IntAct (EBI)O00625
BioGRIDPIR
STRING (EMBL)PIR
ZODIACPIR
Ontologies - Pathways
QuickGOO00625
Ontology : AmiGOtranscription coregulator activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  transcription by RNA polymerase II  digestion  quercetin 2,3-dioxygenase activity  quercetin 2,3-dioxygenase activity  quercetin 2,3-dioxygenase activity  monocyte differentiation  monocyte differentiation  metal ion binding  
Ontology : EGO-EBItranscription coregulator activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  transcription by RNA polymerase II  digestion  quercetin 2,3-dioxygenase activity  quercetin 2,3-dioxygenase activity  quercetin 2,3-dioxygenase activity  monocyte differentiation  monocyte differentiation  metal ion binding  
Pathways : BIOCARTAY branching of actin filaments [Genes]   
NDEx NetworkPIR
Atlas of Cancer Signalling NetworkPIR
Wikipedia pathwaysPIR
Orthology - Evolution
OrthoDB8544
GeneTree (enSembl)ENSG00000087842
Phylogenetic Trees/Animal Genes : TreeFamPIR
HOGENOMO00625
Homologs : HomoloGenePIR
Homology/Alignments : Family Browser (UCSC)PIR
Gene fusions - Rearrangements
Fusion : QuiverPIR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIR [hg38]
dbVarPIR
ClinVarPIR
MonarchPIR
1000_GenomesPIR 
Exome Variant ServerPIR
GNOMAD BrowserENSG00000087842
Varsome BrowserPIR
Genomic Variants (DGV)PIR [DGVbeta]
DECIPHERPIR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIR 
Mutations
ICGC Data PortalPIR 
TCGA Data PortalPIR 
Broad Tumor PortalPIR
OASIS PortalPIR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIR
Mutations and Diseases : HGMDPIR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch PIR
DgiDB (Drug Gene Interaction Database)PIR
DoCM (Curated mutations)PIR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIR (select a term)
intoGenPIR
Cancer3DPIR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300931   
Orphanet
DisGeNETPIR
MedgenPIR
Genetic Testing Registry PIR
NextProtO00625 [Medical]
GENETestsPIR
Target ValidationPIR
Huge Navigator PIR [HugePedia]
ClinGenPIR
Clinical trials, drugs, therapy
MyCancerGenomePIR
Protein Interactions : CTD
Pharm GKB GenePA134870022
PharosO00625
Clinical trialPIR
Miscellaneous
canSAR (ICR)PIR (select the gene name)
HarmonizomePIR
DataMed IndexPIR
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:39:27 CET 2021

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