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PITRM1 (pitrilysin metallopeptidase 1)

Identity

Alias_namespitrilysin metalloproteinase 1
Alias_symbol (synonym)MP1
KIAA1104
hMP1
PreP
Other alias
HGNC (Hugo) PITRM1
LocusID (NCBI) 10531
Atlas_Id 71932
Location 10p15.2  [Link to chromosome band 10p15]
Location_base_pair Starts at 3179919 and ends at 3215033 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
WDR74 (11q12.3) / PITRM1 (10p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PITRM1   17663
Cards
Entrez_Gene (NCBI)PITRM1  10531  pitrilysin metallopeptidase 1
AliasesMP1; PreP
GeneCards (Weizmann)PITRM1
Ensembl hg19 (Hinxton)ENSG00000107959 [Gene_View]  chr10:3179919-3215033 [Contig_View]  PITRM1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000107959 [Gene_View]  chr10:3179919-3215033 [Contig_View]  PITRM1 [Vega]
ICGC DataPortalENSG00000107959
TCGA cBioPortalPITRM1
AceView (NCBI)PITRM1
Genatlas (Paris)PITRM1
WikiGenes10531
SOURCE (Princeton)PITRM1
Genetics Home Reference (NIH)PITRM1
Genomic and cartography
GoldenPath hg19 (UCSC)PITRM1  -     chr10:3179919-3215033 -  10p15.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PITRM1  -     10p15.2   [Description]    (hg38-Dec_2013)
EnsemblPITRM1 - 10p15.2 [CytoView hg19]  PITRM1 - 10p15.2 [CytoView hg38]
Mapping of homologs : NCBIPITRM1 [Mapview hg19]  PITRM1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA132969 AB029027 AF061243 AK001183 AK002061
RefSeq transcript (Entrez)NM_001242307 NM_001242309 NM_014889 NM_014968
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_008705 NW_004929370
Consensus coding sequences : CCDS (NCBI)PITRM1
Cluster EST : UnigeneHs.528300 [ NCBI ]
CGAP (NCI)Hs.528300
Alternative Splicing GalleryENSG00000107959
Gene ExpressionPITRM1 [ NCBI-GEO ]   PITRM1 [ EBI - ARRAY_EXPRESS ]   PITRM1 [ SEEK ]   PITRM1 [ MEM ]
Gene Expression Viewer (FireBrowse)PITRM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10531
GTEX Portal (Tissue expression)PITRM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5JRX3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5JRX3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5JRX3
Splice isoforms : SwissVarQ5JRX3
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ5JRX3
Domains : Interpro (EBI)Metalloenz_LuxS/M16    Pept_M16_dom    Pept_M16_N    Peptidase_M16_C    Peptidase_M16C_assoc   
Domain families : Pfam (Sanger)M16C_assoc (PF08367)    Peptidase_M16 (PF00675)    Peptidase_M16_C (PF05193)   
Domain families : Pfam (NCBI)pfam08367    pfam00675    pfam05193   
Conserved Domain (NCBI)PITRM1
DMDM Disease mutations10531
Blocks (Seattle)PITRM1
PDB (SRS)4L3T    4NGE   
PDB (PDBSum)4L3T    4NGE   
PDB (IMB)4L3T    4NGE   
PDB (RSDB)4L3T    4NGE   
Structural Biology KnowledgeBase4L3T    4NGE   
SCOP (Structural Classification of Proteins)4L3T    4NGE   
CATH (Classification of proteins structures)4L3T    4NGE   
SuperfamilyQ5JRX3
Human Protein AtlasENSG00000107959
Peptide AtlasQ5JRX3
HPRD07142
IPIIPI00787827   IPI00470936   IPI00908889   IPI00952680   IPI00553109   IPI01018890   IPI01018844   IPI00552238   IPI00552829   
Protein Interaction databases
DIP (DOE-UCLA)Q5JRX3
IntAct (EBI)Q5JRX3
FunCoupENSG00000107959
BioGRIDPITRM1
STRING (EMBL)PITRM1
ZODIACPITRM1
Ontologies - Pathways
QuickGOQ5JRX3
Ontology : AmiGOmetalloendopeptidase activity  mitochondrion  mitochondrial matrix  proteolysis  enzyme activator activity  positive regulation of catalytic activity  metal ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  mitochondrion  mitochondrial matrix  proteolysis  enzyme activator activity  positive regulation of catalytic activity  metal ion binding  
NDEx NetworkPITRM1
Atlas of Cancer Signalling NetworkPITRM1
Wikipedia pathwaysPITRM1
Orthology - Evolution
OrthoDB10531
GeneTree (enSembl)ENSG00000107959
Phylogenetic Trees/Animal Genes : TreeFamPITRM1
HOVERGENQ5JRX3
HOGENOMQ5JRX3
Homologs : HomoloGenePITRM1
Homology/Alignments : Family Browser (UCSC)PITRM1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPITRM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PITRM1
dbVarPITRM1
ClinVarPITRM1
1000_GenomesPITRM1 
Exome Variant ServerPITRM1
ExAC (Exome Aggregation Consortium)PITRM1 (select the gene name)
Genetic variants : HAPMAP10531
Genomic Variants (DGV)PITRM1 [DGVbeta]
DECIPHER (Syndromes)10:3179919-3215033  ENSG00000107959
CONAN: Copy Number AnalysisPITRM1 
Mutations
ICGC Data PortalPITRM1 
TCGA Data PortalPITRM1 
Broad Tumor PortalPITRM1
OASIS PortalPITRM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPITRM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPITRM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PITRM1
DgiDB (Drug Gene Interaction Database)PITRM1
DoCM (Curated mutations)PITRM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PITRM1 (select a term)
intoGenPITRM1
Cancer3DPITRM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPITRM1
Genetic Testing Registry PITRM1
NextProtQ5JRX3 [Medical]
TSGene10531
GENETestsPITRM1
Huge Navigator PITRM1 [HugePedia]
snp3D : Map Gene to Disease10531
BioCentury BCIQPITRM1
ClinGenPITRM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10531
Chemical/Pharm GKB GenePA134902269
Clinical trialPITRM1
Miscellaneous
canSAR (ICR)PITRM1 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePITRM1
EVEXPITRM1
GoPubMedPITRM1
iHOPPITRM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 12:38:42 CET 2017

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