Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PITX3 (paired like homeodomain 3)

Identity

Other aliasASGD1
ASMD
ASOD
CTPP4
CTRCT11
PTX3
HGNC (Hugo) PITX3
LocusID (NCBI) 5309
Atlas_Id 56649
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102230189 and ends at 102241474 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PITX3   9006
Cards
Entrez_Gene (NCBI)PITX3  5309  paired like homeodomain 3
AliasesASGD1; ASMD; ASOD; CTPP4; 
CTRCT11; PTX3
GeneCards (Weizmann)PITX3
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr10:102230189-102241474 [Contig_View]  PITX3 [Vega]
TCGA cBioPortalPITX3
AceView (NCBI)PITX3
Genatlas (Paris)PITX3
WikiGenes5309
SOURCE (Princeton)PITX3
Genetics Home Reference (NIH)PITX3
Genomic and cartography
GoldenPath hg38 (UCSC)PITX3  -     chr10:102230189-102241474 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PITX3  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblPITX3 - 10q24.32 [CytoView hg19]  PITX3 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBIPITX3 [Mapview hg19]  PITX3 [Mapview hg38]
OMIM107250   602669   610623   
Gene and transcription
Genbank (Entrez)AF041339 BC011642 DQ891945 DQ895131 DQ895132
RefSeq transcript (Entrez)NM_005029
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PITX3
Cluster EST : UnigeneHs.137568 [ NCBI ]
CGAP (NCI)Hs.137568
Gene ExpressionPITX3 [ NCBI-GEO ]   PITX3 [ EBI - ARRAY_EXPRESS ]   PITX3 [ SEEK ]   PITX3 [ MEM ]
Gene Expression Viewer (FireBrowse)PITX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5309
GTEX Portal (Tissue expression)PITX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75364   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75364  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75364
Splice isoforms : SwissVarO75364
PhosPhoSitePlusO75364
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    OAR (PS50803)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_Pitx/unc30    OAR_dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    OAR (PF03826)   
Domain families : Pfam (NCBI)pfam00046    pfam03826   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)PITX3
DMDM Disease mutations5309
Blocks (Seattle)PITX3
SuperfamilyO75364
Peptide AtlasO75364
IPIIPI00025313   
Protein Interaction databases
DIP (DOE-UCLA)O75364
IntAct (EBI)O75364
BioGRIDPITX3
STRING (EMBL)PITX3
ZODIACPITX3
Ontologies - Pathways
QuickGOO75364
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  lens development in camera-type eye  lens morphogenesis in camera-type eye  nucleus  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  aging  locomotory behavior  animal organ morphogenesis  negative regulation of gliogenesis  midbrain development  response to immobilization stress  response to cocaine  neuronal cell body  response to morphine  positive regulation of neuron apoptotic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  neuron development  lens fiber cell differentiation  dopaminergic neuron differentiation  dopaminergic neuron differentiation  response to methamphetamine hydrochloride  positive regulation of cell proliferation in midbrain  cellular response to glial cell derived neurotrophic factor  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  lens development in camera-type eye  lens morphogenesis in camera-type eye  nucleus  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  aging  locomotory behavior  animal organ morphogenesis  negative regulation of gliogenesis  midbrain development  response to immobilization stress  response to cocaine  neuronal cell body  response to morphine  positive regulation of neuron apoptotic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  neuron development  lens fiber cell differentiation  dopaminergic neuron differentiation  dopaminergic neuron differentiation  response to methamphetamine hydrochloride  positive regulation of cell proliferation in midbrain  cellular response to glial cell derived neurotrophic factor  
NDEx NetworkPITX3
Atlas of Cancer Signalling NetworkPITX3
Wikipedia pathwaysPITX3
Orthology - Evolution
OrthoDB5309
Phylogenetic Trees/Animal Genes : TreeFamPITX3
HOVERGENO75364
HOGENOMO75364
Homologs : HomoloGenePITX3
Homology/Alignments : Family Browser (UCSC)PITX3
Gene fusions - Rearrangements
Tumor Fusion PortalPITX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPITX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PITX3
dbVarPITX3
ClinVarPITX3
1000_GenomesPITX3 
Exome Variant ServerPITX3
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP5309
Genomic Variants (DGV)PITX3 [DGVbeta]
DECIPHERPITX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPITX3 
Mutations
ICGC Data PortalPITX3 
TCGA Data PortalPITX3 
Broad Tumor PortalPITX3
OASIS PortalPITX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPITX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPITX3
BioMutasearch PITX3
DgiDB (Drug Gene Interaction Database)PITX3
DoCM (Curated mutations)PITX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PITX3 (select a term)
intoGenPITX3
Cancer3DPITX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107250    602669    610623   
Orphanet
DisGeNETPITX3
MedgenPITX3
Genetic Testing Registry PITX3
NextProtO75364 [Medical]
TSGene5309
GENETestsPITX3
Target ValidationPITX3
Huge Navigator PITX3 [HugePedia]
snp3D : Map Gene to Disease5309
BioCentury BCIQPITX3
ClinGenPITX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5309
Chemical/Pharm GKB GenePA33340
Clinical trialPITX3
Miscellaneous
canSAR (ICR)PITX3 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePITX3
EVEXPITX3
GoPubMedPITX3
iHOPPITX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:28:55 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.