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PIWIL1 (piwi-like RNA-mediated gene silencing 1)

Written2013-05Shozo Honda, Yohei Kirino
Department of Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

(Note : for Links provided by Atlas : click)


HGNC Alias symbPIWI
HGNC Previous namepiwi (Drosophila)-like 1
 piwi-like 1 (Drosophila)
LocusID (NCBI) 9271
Atlas_Id 46561
Location 12q24.33  [Link to chromosome band 12q24]
Location_base_pair Starts at 130337887 and ends at 130372599 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping PIWIL1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PIWIL1 (12q24.33)::ADGRL1 (19p13.12)
Note The HIWI gene belongs to an evolutionarily conserved PIWI gene family that comprises four members in human (PIWIL1/HIWI, PIWIL2, PIWIL3/HILI and PIWIL4/HIWI2) (Sasaki et al., 2003).


Note HIWI cDNA was first partially isolated as an ortholog of Drosophila PIWI (Cox et al., 1998) and then fully identified in a human testis cDNA library (Qiao et al., 2002; Sharma et al., 2001).
  HIWI gene occupies a 34445-bp region from positions 130822433 to 130856877 on chromosome 12.
Transcription HIWI has two transcript variants. Variant 1 (NCBI Ref Seq: NM_004764.4) was cloned from a human testis cDNA library (Qiao et al., 2002; Sharma et al., 2001). It is 3591 nt in length and comprises 21 verified exons, of which 20 are coding exons with a total length of 2586 nt. The 5'- and 3'-UTRs are 271 and 734 nt long, respectively. Variant 2 has an alternative 3'-UTR, resulting in shorter protein with truncated C-terminus compared with variant 1. Variant 2 was detected by transcriptome analyses of the "full-length long JAPAN" (FLJ) collection (Ota et al., 2004).


Note HIWI protein (NCBI Ref Seq: NP_004755.2) belongs to the PIWI subgroup of Argonaute family proteins, evolutionarily conserved proteins containing two characteristic protein motifs, PAZ and PIWI (Carmell et al., 2002). Argonaute family proteins can be divided into two subclades, AGO and PIWI, and form complexes with small RNAs to regulate gene expressions (Carmell et al., 2002; Hock and Meister, 2008).
Description The HIWI gene encodes an 861-amino-acid protein (98 kDa). The HIWI protein contains two characteristic protein motifs: a PAZ domain (aa 278-413) and a PIWI domain (aa 556-847). In Argonaute family proteins, the PAZ domain serves as a docking site for the 3'-end of small RNA, whereas the PIWI domain has a structure similar to RNaseH, which cleaves the RNA strand of an RNA-DNA hybrid (Elkayam et al., 2012; Parker and Barford, 2006). Indeed, all three species of the Drosophila PIWI protein family show small RNA-guided RNA cleavage (slicer) activity (Gunawardane et al., 2007; Nishida et al., 2007; Saito et al., 2006). In mouse, MIWI (mouse orthologs of HIWI) and MILI also have the slicer activity, which is essential for transposon silencing and fertility (De Fazio et al., 2011; Reuter et al., 2011). In addition, the HIWI protein contains glycine-arginine-rich repeats mainly in its N-terminus (aa 3-15:GRARARARGRARG; aa18-20:GRG; aa728-730:GRG), and these are the motifs for symmetrical dimethylarginine (sDMA) modifications catalyzed by PRMT5 methyltransferase (Kirino et al., 2009). sDMA positions of MIWI were determined by mass spectrometry (Chen et al., 2009; Vagin et al., 2009). PIWI sDMAs serve as binding elements for TUDOR-domain containing proteins, and the sDMA-dependent protein interactions play crucial roles in piRNA function and germline development (Chen et al., 2011; Siomi et al., 2010).
Expression Expression of the PIWI protein family is restricted to germline cells (Farazi et al., 2008).
Function PIWI protein family was named after the Drosophila protein PIWI (P-element induced wimpy testis) (Carmell et al., 2002; Farazi et al, 2008). The Drosophila PIWI was first identified in a genetic screen for mutants that affect stem cell division in the germline, and subsequent studies demonstrated that Drosophila PIWI is essential for gametogenesis and is a key regulator of female germline stem cells (Cox et al., 1998; Cox et al., 2000; Lin and Spradling, 1997). PIWI protein mutations in various organisms, including mice and zebrafish, commonly cause defects in gametogenesis, indicating evolutionarily conserved essential roles for PIWI proteins in germline development (Carmell et al., 2007; Deng and Lin, 2002; Houwing et al., 2008; Houwing et al., 2007; Kuramochi-Miyagawa et al., 2004). Since 2006, the small RNAs bound to PIWI proteins have been identified and termed PIWI-interacting RNAs (piRNAs) (Siomi et al., 2011). piRNAs are 24-31 nt in length and are a highly complex mix of sequences derived from defined genomic regions called piRNA clusters. Many piRNAs are derived from transposable elements, and PIWI/piRNA complexes play a crucial role in silencing transposons during germline development (Siomi et al., 2011).

Implicated in

Entity Various cancers
Note Although the expression of PIWI family proteins is normally restricted to germline cells, HIWI has been reported to be aberrantly expressed in a variety of cancers (Suzuki et al., 2012).
Entity Seminoma
Note The first report on PIWI expression in cancer was in seminomas (Qiao et al., 2002). HIWI was detected in seminomas but not in non-seminomas, spermatocytic seminomas, or testicular tumors originating from somatic cells such as Sertoli cells and Leydig cells (Qiao et al., 2002).
Entity Gastric cancer
Note HIWI was expressed in gastric cancer cell lines and tissues, and its expression was correlated with precancerous development and cell proliferation (Liu et al., 2006). HIWI expression was also positively correlated with T stage, lymph node metastasis, and clinical TNM, and patients with higher HIWI expression had shorter survival times (Wang et al., 2012).
Entity Sarcoma
Note An increased expression of HIWI mRNA was correlated with prognosis of patients with soft-tissue sarcomas (Taubert et al., 2007). HIWI expression promoted sarcomagenesis in cells, developed sarcoma in mice, and correlated with DNA methylation in sarcoma cells (Siddiqi et al., 2012).
Entity Pancreatic cancer
Note Patients with altered levels of HIWI mRNA had increased risk of tumor-related death (Grochola et al., 2008).
Entity Esophageal cancer
Note The cytoplasmic expression of HIWI significantly correlated with histological grade and poorer clinical outcome (He et al., 2009).
Entity Cervical cancer
Note Elevated HIWI expression was associated with cervical cancer invasion and human papillomavirus infection, but not with patient age or histological grade (Liu et al., 2010a).
Entity Endometrial cancer
Note HIWI was expressed in endometrial adenocarcinoma but did not correlate with pathological features (Liu et al., 2010b).
Entity Glioma
Note The expression level of HIWI was positively correlated with tumor grade, and patients with high HIWI expression had poorer clinical outcomes (Sun et al., 2011).
Entity Colon cancer
Note In colorectal cancer, HIWI expression in early stage and in adjacent non-cancerous tissues negatively correlated with survival rates and times of the patients (Zeng et al., 2011). Among colon cancer patients without lymph node metastasis, those with HIWI-positive tumors had a significantly lower survival rate than those with HIWI-negative tumors (Liu et al., 2012).
Entity Liver cancer
Note HIWI expression in hepatocellular carcinoma tissues was significantly higher than in adjacent normal hepatic tissue and was correlated with metastasis (Jiang et al., 2011). HIWI expression positively correlated with tumor size and metastasis and negatively correlated with survival rates in hepatocellular carcinoma cells and tissues (Zhao et al., 2012).
Entity Lung cancer
Note HIWI knockdown decreased cell proliferation and promoted apoptosis of lung cancer stem cells (Liang et al., 2013; Liang et al., 2012).


MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.
Carmell MA, Girard A, van de Kant HJ, Bourc'his D, Bestor TH, de Rooij DG, Hannon GJ.
Dev Cell. 2007 Apr;12(4):503-14. Epub 2007 Mar 29.
PMID 17395546
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.
Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, Guo Y, Tenaglia E, Xu C, Gish G, Min J, Pawson T.
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20336-41. doi: 10.1073/pnas.0911640106. Epub 2009 Nov 16.
PMID 19918066
Deciphering arginine methylation: Tudor tells the tale.
Chen C, Nott TJ, Jin J, Pawson T.
Nat Rev Mol Cell Biol. 2011 Sep 14;12(10):629-42. doi: 10.1038/nrm3185. (REVIEW)
PMID 21915143
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells.
Cox DN, Chao A, Lin H.
Development. 2000 Feb;127(3):503-14.
PMID 10631171
The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.
De Fazio S, Bartonicek N, Di Giacomo M, Abreu-Goodger C, Sankar A, Funaya C, Antony C, Moreira PN, Enright AJ, O'Carroll D.
Nature. 2011 Oct 23;480(7376):259-63. doi: 10.1038/nature10547.
PMID 22020280
miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis.
Deng W, Lin H.
Dev Cell. 2002 Jun;2(6):819-30.
PMID 12062093
The structure of human argonaute-2 in complex with miR-20a.
Elkayam E, Kuhn CD, Tocilj A, Haase AD, Greene EM, Hannon GJ, Joshua-Tor L.
Cell. 2012 Jul 6;150(1):100-10. doi: 10.1016/j.cell.2012.05.017. Epub 2012 Jun 7.
PMID 22682761
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members.
Farazi TA, Juranek SA, Tuschl T.
Development. 2008 Apr;135(7):1201-14. doi: 10.1242/dev.005629. Epub 2008 Feb 20. (REVIEW)
PMID 18287206
The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death.
Grochola LF, Greither T, Taubert H, Moller P, Knippschild U, Udelnow A, Henne-Bruns D, Wurl P.
Br J Cancer. 2008 Oct 7;99(7):1083-8. doi: 10.1038/sj.bjc.6604653. Epub 2008 Sep 9.
PMID 18781170
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila.
Gunawardane LS, Saito K, Nishida KM, Miyoshi K, Kawamura Y, Nagami T, Siomi H, Siomi MC.
Science. 2007 Mar 16;315(5818):1587-90. Epub 2007 Feb 22.
PMID 17322028
Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis.
He W, Wang Z, Wang Q, Fan Q, Shou C, Wang J, Giercksky KE, Nesland JM, Suo Z.
BMC Cancer. 2009 Dec 8;9:426. doi: 10.1186/1471-2407-9-426.
PMID 19995427
The Argonaute protein family.
Hock J, Meister G.
Genome Biol. 2008;9(2):210. doi: 10.1186/gb-2008-9-2-210. Epub 2008 Feb 26. (REVIEW)
PMID 18304383
Zili is required for germ cell differentiation and meiosis in zebrafish.
Houwing S, Berezikov E, Ketting RF.
EMBO J. 2008 Oct 22;27(20):2702-11. doi: 10.1038/emboj.2008.204. Epub 2008 Oct 2.
PMID 18833190
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.
Houwing S, Kamminga LM, Berezikov E, Cronembold D, Girard A, van den Elst H, Filippov DV, Blaser H, Raz E, Moens CB, Plasterk RH, Hannon GJ, Draper BW, Ketting RF.
Cell. 2007 Apr 6;129(1):69-82.
PMID 17418787
Expression of HIWI in human hepatocellular carcinoma.
Jiang J, Zhang H, Tang Q, Hao B, Shi R.
Cell Biochem Biophys. 2011 Sep;61(1):53-8. doi: 10.1007/s12013-011-9160-1.
PMID 21327579
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.
Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z.
Nat Cell Biol. 2009 May;11(5):652-8. doi: 10.1038/ncb1872. Epub 2009 Apr 19.
PMID 19377467
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.
Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y, Nakano T.
Development. 2004 Feb;131(4):839-49. Epub 2004 Jan 21.
PMID 14736746
Hiwi knockdown inhibits the growth of lung cancer in nude mice.
Liang D, Dong M, Hu LJ, Fang ZH, Xu X, Shi EH, Yang YJ.
Asian Pac J Cancer Prev. 2013;14(2):1067-72.
PMID 23621188
Effect of RNA interference-related HiWi gene expression on the proliferation and apoptosis of lung cancer stem cells.
Liang D, Fang Z, Dong M, Liang C, Xing C, Zhao J, Yang Y.
Oncol Lett. 2012 Jul;4(1):146-150. Epub 2012 Apr 11.
PMID 22807978
A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary.
Lin H, Spradling AC.
Development. 1997 Jun;124(12):2463-76.
PMID 9199372
Combined phenotype of 4 markers improves prognostic value of patients with colon cancer.
Liu C, Qu L, Dong B, Xing X, Ren T, Zeng Y, Jiang B, Meng L, Wu J, Shou C.
Am J Med Sci. 2012 Apr;343(4):295-302. doi: 10.1097/MAJ.0b013e31822cb4cd.
PMID 22261620
Expression of PSCA, PIWIL1, and TBX2 in endometrial adenocarcinoma.
Liu WK, Jiang XY, Zhang ZX.
Onkologie. 2010b;33(5):241-5. doi: 10.1159/000305098. Epub 2010 Apr 21.
PMID 20502058
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells.
Liu X, Sun Y, Guo J, Ma H, Li J, Dong B, Jin G, Zhang J, Wu J, Meng L, Shou C.
Int J Cancer. 2006 Apr 15;118(8):1922-9.
PMID 16287078
Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad.
Nishida KM, Saito K, Mori T, Kawamura Y, Nagami-Okada T, Inagaki S, Siomi H, Siomi MC.
RNA. 2007 Nov;13(11):1911-22. Epub 2007 Sep 13.
PMID 17872506
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S.
Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21.
PMID 14702039
Argonaute: A scaffold for the function of short regulatory RNAs.
Parker JS, Barford D.
Trends Biochem Sci. 2006 Nov;31(11):622-30. Epub 2006 Oct 6. (REVIEW)
PMID 17029813
Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas.
Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H.
Oncogene. 2002 Jun 6;21(25):3988-99.
PMID 12037681
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.
Reuter M, Berninger P, Chuma S, Shah H, Hosokawa M, Funaya C, Antony C, Sachidanandam R, Pillai RS.
Nature. 2011 Nov 27;480(7376):264-7. doi: 10.1038/nature10672.
PMID 22121019
Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome.
Saito K, Nishida KM, Mori T, Kawamura Y, Miyoshi K, Nagami T, Siomi H, Siomi MC.
Genes Dev. 2006 Aug 15;20(16):2214-22. Epub 2006 Aug 1.
PMID 16882972
Identification of eight members of the Argonaute family in the human genome small star, filled.
Sasaki T, Shiohama A, Minoshima S, Shimizu N.
Genomics. 2003 Sep;82(3):323-30.
PMID 12906857
Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.
Sharma AK, Nelson MC, Brandt JE, Wessman M, Mahmud N, Weller KP, Hoffman R.
Blood. 2001 Jan 15;97(2):426-34.
PMID 11154219
Hiwi mediated tumorigenesis is associated with DNA hypermethylation.
Siddiqi S, Terry M, Matushansky I.
PLoS One. 2012;7(3):e33711. doi: 10.1371/journal.pone.0033711. Epub 2012 Mar 16.
PMID 22438986
How does the royal family of Tudor rule the PIWI-interacting RNA pathway?
Siomi MC, Mannen T, Siomi H.
Genes Dev. 2010 Apr 1;24(7):636-46. doi: 10.1101/gad.1899210. (REVIEW)
PMID 20360382
PIWI-interacting small RNAs: the vanguard of genome defence.
Siomi MC, Sato K, Pezic D, Aravin AA.
Nat Rev Mol Cell Biol. 2011 Apr;12(4):246-58. doi: 10.1038/nrm3089. (REVIEW)
PMID 21427766
Clinical significance of Hiwi gene expression in gliomas.
Sun G, Wang Y, Sun L, Luo H, Liu N, Fu Z, You Y.
Brain Res. 2011 Feb 10;1373:183-8. doi: 10.1016/j.brainres.2010.11.097. Epub 2010 Dec 4.
PMID 21138738
PIWI Expression and Function in Cancer.
Suzuki R, Honda S, Kirino Y.
Front Genet. 2012;3:204. doi: 10.3389/fgene.2012.00204. Epub 2012 Oct 16.
PMID 23087701
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma.
Taubert H, Greither T, Kaushal D, Wurl P, Bache M, Bartel F, Kehlen A, Lautenschlager C, Harris L, Kraemer K, Meye A, Kappler M, Schmidt H, Holzhausen HJ, Hauptmann S.
Oncogene. 2007 Feb 15;26(7):1098-100. Epub 2006 Sep 4.
PMID 16953229
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.
Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon GJ, Aravin AA.
Genes Dev. 2009 Aug 1;23(15):1749-62. doi: 10.1101/gad.1814809. Epub 2009 Jul 7.
PMID 19584108
The PIWI protein acts as a predictive marker for human gastric cancer.
Wang Y, Liu Y, Shen X, Zhang X, Chen X, Yang C, Gao H.
Int J Clin Exp Pathol. 2012;5(4):315-25. Epub 2012 Apr 19.
PMID 22670175
HIWI expression profile in cancer cells and its prognostic value for patients with colorectal cancer.
Zeng Y, Qu LK, Meng L, Liu CY, Dong B, Xing XF, Wu J, Shou CC.
Chin Med J (Engl). 2011 Jul;124(14):2144-9.
PMID 21933617
HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection.
Zhao YM, Zhou JM, Wang LR, He HW, Wang XL, Tao ZH, Sun HC, Wu WZ, Fan J, Tang ZY, Wang L.
Cancer. 2012 May 15;118(10):2708-17. doi: 10.1002/cncr.26524. Epub 2011 Oct 11.
PMID 21989785


This paper should be referenced as such :
Honda, S ; Kirino, Y
PIWIL1 (piwi-like RNA-mediated gene silencing 1)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(12):833-836.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)PIWIL1   9007
Entrez_Gene (NCBI)PIWIL1    piwi like RNA-mediated gene silencing 1
AliasesCT80.1; HIWI; MIWI; PIWI
GeneCards (Weizmann)PIWIL1
Ensembl hg19 (Hinxton)ENSG00000125207 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125207 [Gene_View]  ENSG00000125207 [Sequence]  chr12:130337887-130372599 [Contig_View]  PIWIL1 [Vega]
ICGC DataPortalENSG00000125207
Genatlas (Paris)PIWIL1
SOURCE (Princeton)PIWIL1
Genetics Home Reference (NIH)PIWIL1
Genomic and cartography
GoldenPath hg38 (UCSC)PIWIL1  -     chr12:130337887-130372599 +  12q24.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIWIL1  -     12q24.33   [Description]    (hg19-Feb_2009)
GoldenPathPIWIL1 - 12q24.33 [CytoView hg19]  PIWIL1 - 12q24.33 [CytoView hg38]
Genome Data Viewer NCBIPIWIL1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB274731 AF104260 AF264004 AF387507 AK093133
RefSeq transcript (Entrez)NM_001190971 NM_004764
Consensus coding sequences : CCDS (NCBI)PIWIL1
Gene ExpressionPIWIL1 [ NCBI-GEO ]   PIWIL1 [ EBI - ARRAY_EXPRESS ]   PIWIL1 [ SEEK ]   PIWIL1 [ MEM ]
Gene Expression Viewer (FireBrowse)PIWIL1 [ Firebrowse - Broad ]
GenevisibleExpression of PIWIL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9271
GTEX Portal (Tissue expression)PIWIL1
Human Protein AtlasENSG00000125207-PIWIL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96J94   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96J94  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96J94
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)ArgoL1    GAGE    PAZ_dom    PAZ_dom_sf    Piwi    PIWIL1    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)ArgoL1 (PF08699)    GAGE (PF05831)    PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam08699    pfam05831    pfam02170    pfam02171   
Domain families : Smart (EMBL)GAGE (SM01379)  PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)PIWIL1
PDB (RSDB)2L5C    2L5D    3O3I    3O6E    3O7V    6PI7   
PDB Europe2L5C    2L5D    3O3I    3O6E    3O7V    6PI7   
PDB (PDBSum)2L5C    2L5D    3O3I    3O6E    3O7V    6PI7   
PDB (IMB)2L5C    2L5D    3O3I    3O6E    3O7V    6PI7   
Structural Biology KnowledgeBase2L5C    2L5D    3O3I    3O6E    3O7V    6PI7   
SCOP (Structural Classification of Proteins)2L5C    2L5D    3O3I    3O6E    3O7V    6PI7   
CATH (Classification of proteins structures)2L5C    2L5D    3O3I    3O6E    3O7V    6PI7   
AlphaFold pdb e-kbQ96J94   
Human Protein Atlas [tissue]ENSG00000125207-PIWIL1 [tissue]
Protein Interaction databases
IntAct (EBI)Q96J94
Ontologies - Pathways
Ontology : AmiGOsingle-stranded RNA binding  mRNA binding  endoribonuclease activity  protein binding  nucleus  cytoplasm  regulation of translation  multicellular organism development  spermatogenesis  spermatid development  spermatid development  negative regulation of transposition  protein kinase binding  gene silencing by RNA  chromatoid body  piRNA binding  piRNA metabolic process  spermatogenesis, exchange of chromosomal proteins  P granule  metal ion binding  meiotic cell cycle  RNA phosphodiester bond hydrolysis, endonucleolytic  dense body  mRNA cap binding complex binding  polysome binding  
Ontology : EGO-EBIsingle-stranded RNA binding  mRNA binding  endoribonuclease activity  protein binding  nucleus  cytoplasm  regulation of translation  multicellular organism development  spermatogenesis  spermatid development  spermatid development  negative regulation of transposition  protein kinase binding  gene silencing by RNA  chromatoid body  piRNA binding  piRNA metabolic process  spermatogenesis, exchange of chromosomal proteins  P granule  metal ion binding  meiotic cell cycle  RNA phosphodiester bond hydrolysis, endonucleolytic  dense body  mRNA cap binding complex binding  polysome binding  
Pathways : KEGGDorso-ventral axis formation   
NDEx NetworkPIWIL1
Atlas of Cancer Signalling NetworkPIWIL1
Wikipedia pathwaysPIWIL1
Orthology - Evolution
GeneTree (enSembl)ENSG00000125207
Phylogenetic Trees/Animal Genes : TreeFamPIWIL1
Homologs : HomoloGenePIWIL1
Homology/Alignments : Family Browser (UCSC)PIWIL1
Gene fusions - Rearrangements
Fusion Cancer (Beijing)PIWIL1 [12q24.33]  -  LPHN1 [FUSC004258]
Fusion : QuiverPIWIL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIWIL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIWIL1
Exome Variant ServerPIWIL1
GNOMAD BrowserENSG00000125207
Varsome BrowserPIWIL1
ACMGPIWIL1 variants
Genomic Variants (DGV)PIWIL1 [DGVbeta]
DECIPHERPIWIL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIWIL1 
ICGC Data PortalPIWIL1 
TCGA Data PortalPIWIL1 
Broad Tumor PortalPIWIL1
OASIS PortalPIWIL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIWIL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIWIL1
Mutations and Diseases : HGMDPIWIL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)PIWIL1
DoCM (Curated mutations)PIWIL1
CIViC (Clinical Interpretations of Variants in Cancer)PIWIL1
NCG (London)PIWIL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry PIWIL1
NextProtQ96J94 [Medical]
Target ValidationPIWIL1
Huge Navigator PIWIL1 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDPIWIL1
Pharm GKB GenePA33341
Clinical trialPIWIL1
DataMed IndexPIWIL1
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:25:13 CEST 2021

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