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PIWIL4 (piwi-like RNA-mediated gene silencing 4)

Identity

Alias_namespiwi-like 4 (Drosophila)
Alias_symbol (synonym)FLJ36156
HIWI2
Miwi2
Other aliasMIWI2
HGNC (Hugo) PIWIL4
LocusID (NCBI) 143689
Atlas_Id 52078
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 94300474 and ends at 94354587 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PIWIL4 (11q21) / LGR4 (11p14.1)SLC35F2 (11q22.3) / PIWIL4 (11q21)SLC35F2 11q22.3 / PIWIL4 11q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PIWIL4   18444
Cards
Entrez_Gene (NCBI)PIWIL4  143689  piwi-like RNA-mediated gene silencing 4
AliasesHIWI2; MIWI2
GeneCards (Weizmann)PIWIL4
Ensembl hg19 (Hinxton)ENSG00000134627 [Gene_View]  chr11:94300474-94354587 [Contig_View]  PIWIL4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134627 [Gene_View]  chr11:94300474-94354587 [Contig_View]  PIWIL4 [Vega]
ICGC DataPortalENSG00000134627
TCGA cBioPortalPIWIL4
AceView (NCBI)PIWIL4
Genatlas (Paris)PIWIL4
WikiGenes143689
SOURCE (Princeton)PIWIL4
Genetics Home Reference (NIH)PIWIL4
Genomic and cartography
GoldenPath hg19 (UCSC)PIWIL4  -     chr11:94300474-94354587 +  11q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PIWIL4  -     11q21   [Description]    (hg38-Dec_2013)
EnsemblPIWIL4 - 11q21 [CytoView hg19]  PIWIL4 - 11q21 [CytoView hg38]
Mapping of homologs : NCBIPIWIL4 [Mapview hg19]  PIWIL4 [Mapview hg38]
OMIM610315   
Gene and transcription
Genbank (Entrez)AB079366 AF086344 AK093475 AK096837 AK293616
RefSeq transcript (Entrez)NM_152431
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929380
Consensus coding sequences : CCDS (NCBI)PIWIL4
Cluster EST : UnigeneHs.660188 [ NCBI ]
CGAP (NCI)Hs.660188
Alternative Splicing GalleryENSG00000134627
Gene ExpressionPIWIL4 [ NCBI-GEO ]   PIWIL4 [ EBI - ARRAY_EXPRESS ]   PIWIL4 [ SEEK ]   PIWIL4 [ MEM ]
Gene Expression Viewer (FireBrowse)PIWIL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143689
GTEX Portal (Tissue expression)PIWIL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3Z4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3Z4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3Z4
Splice isoforms : SwissVarQ7Z3Z4
PhosPhoSitePlusQ7Z3Z4
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)Argonaute_N    PAZ_dom    Piwi    RNaseH-like_dom   
Domain families : Pfam (Sanger)ArgoN (PF16486)    PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam16486    pfam02170    pfam02171   
Domain families : Smart (EMBL)PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)PIWIL4
DMDM Disease mutations143689
Blocks (Seattle)PIWIL4
SuperfamilyQ7Z3Z4
Human Protein AtlasENSG00000134627
Peptide AtlasQ7Z3Z4
HPRD11435
IPIIPI00783354   IPI00747170   IPI00923483   IPI01010795   IPI01009644   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3Z4
IntAct (EBI)Q7Z3Z4
FunCoupENSG00000134627
BioGRIDPIWIL4
STRING (EMBL)PIWIL4
ZODIACPIWIL4
Ontologies - Pathways
QuickGOQ7Z3Z4
Ontology : AmiGOnucleus  cytoplasm  regulation of translation  multicellular organism development  spermatogenesis  cell differentiation  gene silencing by RNA  piRNA binding  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  meiotic cell cycle  piP-body  
Ontology : EGO-EBInucleus  cytoplasm  regulation of translation  multicellular organism development  spermatogenesis  cell differentiation  gene silencing by RNA  piRNA binding  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  meiotic cell cycle  piP-body  
Pathways : KEGGDorso-ventral axis formation   
NDEx NetworkPIWIL4
Atlas of Cancer Signalling NetworkPIWIL4
Wikipedia pathwaysPIWIL4
Orthology - Evolution
OrthoDB143689
GeneTree (enSembl)ENSG00000134627
Phylogenetic Trees/Animal Genes : TreeFamPIWIL4
HOVERGENQ7Z3Z4
HOGENOMQ7Z3Z4
Homologs : HomoloGenePIWIL4
Homology/Alignments : Family Browser (UCSC)PIWIL4
Gene fusions - Rearrangements
Fusion : MitelmanSLC35F2/PIWIL4 [11q22.3/11q21]  [t(11;11)(q21;q22)]  
Fusion: TCGASLC35F2 11q22.3 PIWIL4 11q21 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIWIL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIWIL4
dbVarPIWIL4
ClinVarPIWIL4
1000_GenomesPIWIL4 
Exome Variant ServerPIWIL4
ExAC (Exome Aggregation Consortium)PIWIL4 (select the gene name)
Genetic variants : HAPMAP143689
Genomic Variants (DGV)PIWIL4 [DGVbeta]
DECIPHER (Syndromes)11:94300474-94354587  ENSG00000134627
CONAN: Copy Number AnalysisPIWIL4 
Mutations
ICGC Data PortalPIWIL4 
TCGA Data PortalPIWIL4 
Broad Tumor PortalPIWIL4
OASIS PortalPIWIL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIWIL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPIWIL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PIWIL4
DgiDB (Drug Gene Interaction Database)PIWIL4
DoCM (Curated mutations)PIWIL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PIWIL4 (select a term)
intoGenPIWIL4
Cancer3DPIWIL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610315   
Orphanet
MedgenPIWIL4
Genetic Testing Registry PIWIL4
NextProtQ7Z3Z4 [Medical]
TSGene143689
GENETestsPIWIL4
Huge Navigator PIWIL4 [HugePedia]
snp3D : Map Gene to Disease143689
BioCentury BCIQPIWIL4
ClinGenPIWIL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD143689
Chemical/Pharm GKB GenePA38333
Clinical trialPIWIL4
Miscellaneous
canSAR (ICR)PIWIL4 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePIWIL4
EVEXPIWIL4
GoPubMedPIWIL4
iHOPPIWIL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:29 CEST 2017

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