PIWIL4 (piwi like RNA-mediated gene silencing 4)

2011-02-01  

Identity

HGNC
PIWIL4
LOCATION
11q21
LOCUSID
143689
ALIAS
HIWI2,MIWI2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 143689
MIM: 610315
HGNC: 18444
Ensembl: ENSG00000134627

Variants:

dbSNP: 143689
ClinVar: 143689
TCGA: ENSG00000134627
COSMIC: PIWIL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134627ENST00000299001Q7Z3Z4
ENSG00000134627ENST00000299001A0A140VKG8
ENSG00000134627ENST00000446230Q7Z3Z4
ENSG00000134627ENST00000537419F5H116
ENSG00000134627ENST00000543336Q7Z3Z4
ENSG00000134627ENST00000545603F5GX26

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Dorso-ventral axis formationKEGGko04320
Dorso-ventral axis formationKEGGhsa04320
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
PIWI-interacting RNA (piRNA) biogenesisREACTOMER-HSA-5601884

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
270588232016CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201468082010Argonaute proteins: potential biomarkers for human colon cancer.47
250382522014The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells.43
175443732007The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.29
207219752010Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.24
266468992015Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.23
209401372010Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.21
209401372010Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.21
269575402016The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer.15

Citation

Dessen P

PIWIL4 (piwi like RNA-mediated gene silencing 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52078/piwil4