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PIWIL4 (piwi like RNA-mediated gene silencing 4)

Identity

Alias (NCBI)HIWI2
MIWI2
HGNC (Hugo) PIWIL4
HGNC Alias symbFLJ36156
HIWI2
Miwi2
HGNC Previous namepiwi-like 4 (Drosophila)
LocusID (NCBI) 143689
Atlas_Id 52078
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 94567368 and ends at 94621421 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PIWIL4 (11q21) / LGR4 (11p14.1)SLC35F2 (11q22.3) / PIWIL4 (11q21)SLC35F2 11q22.3 / PIWIL4 11q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PIWIL4   18444
Cards
Entrez_Gene (NCBI)PIWIL4    piwi like RNA-mediated gene silencing 4
AliasesHIWI2; MIWI2
GeneCards (Weizmann)PIWIL4
Ensembl hg19 (Hinxton)ENSG00000134627 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134627 [Gene_View]  ENSG00000134627 [Sequence]  chr11:94567368-94621421 [Contig_View]  PIWIL4 [Vega]
ICGC DataPortalENSG00000134627
TCGA cBioPortalPIWIL4
AceView (NCBI)PIWIL4
Genatlas (Paris)PIWIL4
SOURCE (Princeton)PIWIL4
Genetics Home Reference (NIH)PIWIL4
Genomic and cartography
GoldenPath hg38 (UCSC)PIWIL4  -     chr11:94567368-94621421 +  11q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PIWIL4  -     11q21   [Description]    (hg19-Feb_2009)
GoldenPathPIWIL4 - 11q21 [CytoView hg19]  PIWIL4 - 11q21 [CytoView hg38]
ImmunoBaseENSG00000134627
Genome Data Viewer NCBIPIWIL4 [Mapview hg19]  
OMIM610315   
Gene and transcription
Genbank (Entrez)AB079366 AF086344 AK093475 AK096837 AK293616
RefSeq transcript (Entrez)NM_152431
Consensus coding sequences : CCDS (NCBI)PIWIL4
Gene ExpressionPIWIL4 [ NCBI-GEO ]   PIWIL4 [ EBI - ARRAY_EXPRESS ]   PIWIL4 [ SEEK ]   PIWIL4 [ MEM ]
Gene Expression Viewer (FireBrowse)PIWIL4 [ Firebrowse - Broad ]
GenevisibleExpression of PIWIL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143689
GTEX Portal (Tissue expression)PIWIL4
Human Protein AtlasENSG00000134627-PIWIL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3Z4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3Z4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3Z4
PhosPhoSitePlusQ7Z3Z4
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)PAZ_dom    PAZ_dom_sf    Piwi    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam02170    pfam02171   
Domain families : Smart (EMBL)PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)PIWIL4
SuperfamilyQ7Z3Z4
AlphaFold pdb e-kbQ7Z3Z4   
Human Protein Atlas [tissue]ENSG00000134627-PIWIL4 [tissue]
HPRD11435
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3Z4
IntAct (EBI)Q7Z3Z4
BioGRIDPIWIL4
STRING (EMBL)PIWIL4
ZODIACPIWIL4
Ontologies - Pathways
QuickGOQ7Z3Z4
Ontology : AmiGOendoribonuclease activity  nucleus  nucleus  cytoplasm  cytoplasm  regulation of translation  multicellular organism development  spermatogenesis  negative regulation of transposition  epithelial structure maintenance  cell differentiation  gene silencing by RNA  piRNA binding  piRNA binding  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  meiotic cell cycle  piP-body  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBIendoribonuclease activity  nucleus  nucleus  cytoplasm  cytoplasm  regulation of translation  multicellular organism development  spermatogenesis  negative regulation of transposition  epithelial structure maintenance  cell differentiation  gene silencing by RNA  piRNA binding  piRNA binding  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  meiotic cell cycle  piP-body  RNA phosphodiester bond hydrolysis, endonucleolytic  
Pathways : KEGGDorso-ventral axis formation   
NDEx NetworkPIWIL4
Atlas of Cancer Signalling NetworkPIWIL4
Wikipedia pathwaysPIWIL4
Orthology - Evolution
OrthoDB143689
GeneTree (enSembl)ENSG00000134627
Phylogenetic Trees/Animal Genes : TreeFamPIWIL4
Homologs : HomoloGenePIWIL4
Homology/Alignments : Family Browser (UCSC)PIWIL4
Gene fusions - Rearrangements
Fusion : MitelmanSLC35F2/PIWIL4 [11q22.3/11q21]  
Fusion : QuiverPIWIL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPIWIL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PIWIL4
dbVarPIWIL4
ClinVarPIWIL4
MonarchPIWIL4
1000_GenomesPIWIL4 
Exome Variant ServerPIWIL4
GNOMAD BrowserENSG00000134627
Varsome BrowserPIWIL4
ACMGPIWIL4 variants
VarityQ7Z3Z4
Genomic Variants (DGV)PIWIL4 [DGVbeta]
DECIPHERPIWIL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPIWIL4 
Mutations
ICGC Data PortalPIWIL4 
TCGA Data PortalPIWIL4 
Broad Tumor PortalPIWIL4
OASIS PortalPIWIL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPIWIL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPIWIL4
Mutations and Diseases : HGMDPIWIL4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPIWIL4
DgiDB (Drug Gene Interaction Database)PIWIL4
DoCM (Curated mutations)PIWIL4
CIViC (Clinical Interpretations of Variants in Cancer)PIWIL4
Cancer3DPIWIL4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610315   
Orphanet
DisGeNETPIWIL4
MedgenPIWIL4
Genetic Testing Registry PIWIL4
NextProtQ7Z3Z4 [Medical]
GENETestsPIWIL4
Target ValidationPIWIL4
Huge Navigator PIWIL4 [HugePedia]
ClinGenPIWIL4
Clinical trials, drugs, therapy
MyCancerGenomePIWIL4
Protein Interactions : CTDPIWIL4
Pharm GKB GenePA38333
PharosQ7Z3Z4
Clinical trialPIWIL4
Miscellaneous
canSAR (ICR)PIWIL4
HarmonizomePIWIL4
DataMed IndexPIWIL4
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPIWIL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:27 CEST 2021

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