PJA2 (praja ring finger ubiquitin ligase 2)

2013-02-01  

Identity

HGNC
LOCATION
5q21.3
LOCUSID
ALIAS
Neurodap1,RNF131
FUSION GENES

Other Information

Locus ID:

NCBI: 9867
HGNC: 17481
Ensembl: ENSG00000198961

Variants:

dbSNP: 9867
ClinVar: 9867
TCGA: ENSG00000198961
COSMIC: PJA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198961ENST00000361189O43164
ENSG00000198961ENST00000361557O43164

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
236520102013Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.34
283456032017PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.10
271956772016praja2 regulates KSR1 stability and mitogenic signaling.6
229487572012Expression of the ring ligase PRAJA2 in thyroid cancer.5
239318492013Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.3

Citation

Dessen P

PJA2 (praja ring finger ubiquitin ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53166/pja2