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PJA2 (praja ring finger ubiquitin ligase 2)

Identity

Alias_namesRNF131
ring finger protein 131
praja ring finger 2
praja ring finger 2, E3 ubiquitin protein ligase
Alias_symbol (synonym)KIAA0438
Neurodap1
Other alias
HGNC (Hugo) PJA2
LocusID (NCBI) 9867
Atlas_Id 53166
Location 5q21.3  [Link to chromosome band 5q21]
Location_base_pair Starts at 109334709 and ends at 109409974 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYO5A (15q21.2) / PJA2 (5q21.3)PJA2 (5q21.3) / ADGRV1 (5q14.3)PJA2 (5q21.3) / FER (5q21.3)
PJA2 (5q21.3) / MALAT1 (11q13.1)PJA2 (5q21.3) / PJA2 (5q21.3)SCP2 (1p32.3) / PJA2 (5q21.3)
TMOD3 (15q21.2) / PJA2 (5q21.3)PJA2 5q21.3 GPR98

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PJA2   17481
Cards
Entrez_Gene (NCBI)PJA2  9867  praja ring finger ubiquitin ligase 2
AliasesNeurodap1; RNF131
GeneCards (Weizmann)PJA2
Ensembl hg19 (Hinxton)ENSG00000198961 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198961 [Gene_View]  chr5:109334709-109409974 [Contig_View]  PJA2 [Vega]
ICGC DataPortalENSG00000198961
TCGA cBioPortalPJA2
AceView (NCBI)PJA2
Genatlas (Paris)PJA2
WikiGenes9867
SOURCE (Princeton)PJA2
Genetics Home Reference (NIH)PJA2
Genomic and cartography
GoldenPath hg38 (UCSC)PJA2  -     chr5:109334709-109409974 -  5q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PJA2  -     5q21.3   [Description]    (hg19-Feb_2009)
EnsemblPJA2 - 5q21.3 [CytoView hg19]  PJA2 - 5q21.3 [CytoView hg38]
Mapping of homologs : NCBIPJA2 [Mapview hg19]  PJA2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB007898 AK291759 BC030826 BM469517 BM681899
RefSeq transcript (Entrez)NM_014819
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PJA2
Cluster EST : UnigeneHs.483036 [ NCBI ]
CGAP (NCI)Hs.483036
Alternative Splicing GalleryENSG00000198961
Gene ExpressionPJA2 [ NCBI-GEO ]   PJA2 [ EBI - ARRAY_EXPRESS ]   PJA2 [ SEEK ]   PJA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PJA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9867
GTEX Portal (Tissue expression)PJA2
Human Protein AtlasENSG00000198961-PJA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43164   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43164  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43164
Splice isoforms : SwissVarO43164
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusO43164
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Praja-2    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)PJA2
DMDM Disease mutations9867
Blocks (Seattle)PJA2
SuperfamilyO43164
Human Protein Atlas [tissue]ENSG00000198961-PJA2 [tissue]
Peptide AtlasO43164
HPRD11436
IPIIPI00006557   IPI00827761   
Protein Interaction databases
DIP (DOE-UCLA)O43164
IntAct (EBI)O43164
FunCoupENSG00000198961
BioGRIDPJA2
STRING (EMBL)PJA2
ZODIACPJA2
Ontologies - Pathways
QuickGOO43164
Ontology : AmiGOGolgi membrane  ubiquitin-protein transferase activity  cytoplasm  endoplasmic reticulum membrane  plasma membrane  long-term memory  zinc ion binding  regulation of protein kinase A signaling  postsynaptic density  protein ubiquitination  protein ubiquitination  cell junction  protein kinase A catalytic subunit binding  protein kinase A regulatory subunit binding  hippo signaling  intermediate filament cytoskeleton  postsynaptic membrane  ubiquitin protein ligase activity  
Ontology : EGO-EBIGolgi membrane  ubiquitin-protein transferase activity  cytoplasm  endoplasmic reticulum membrane  plasma membrane  long-term memory  zinc ion binding  regulation of protein kinase A signaling  postsynaptic density  protein ubiquitination  protein ubiquitination  cell junction  protein kinase A catalytic subunit binding  protein kinase A regulatory subunit binding  hippo signaling  intermediate filament cytoskeleton  postsynaptic membrane  ubiquitin protein ligase activity  
NDEx NetworkPJA2
Atlas of Cancer Signalling NetworkPJA2
Wikipedia pathwaysPJA2
Orthology - Evolution
OrthoDB9867
GeneTree (enSembl)ENSG00000198961
Phylogenetic Trees/Animal Genes : TreeFamPJA2
HOVERGENO43164
HOGENOMO43164
Homologs : HomoloGenePJA2
Homology/Alignments : Family Browser (UCSC)PJA2
Gene fusions - Rearrangements
Fusion : MitelmanPJA2/ADGRV1 [5q21.3/5q14.3]  
Fusion: TCGA_MDACCPJA2 5q21.3 GPR98 LUSC
Tumor Fusion PortalPJA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPJA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PJA2
dbVarPJA2
ClinVarPJA2
1000_GenomesPJA2 
Exome Variant ServerPJA2
ExAC (Exome Aggregation Consortium)ENSG00000198961
GNOMAD BrowserENSG00000198961
Genetic variants : HAPMAP9867
Genomic Variants (DGV)PJA2 [DGVbeta]
DECIPHERPJA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPJA2 
Mutations
ICGC Data PortalPJA2 
TCGA Data PortalPJA2 
Broad Tumor PortalPJA2
OASIS PortalPJA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPJA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPJA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PJA2
DgiDB (Drug Gene Interaction Database)PJA2
DoCM (Curated mutations)PJA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PJA2 (select a term)
intoGenPJA2
Cancer3DPJA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPJA2
MedgenPJA2
Genetic Testing Registry PJA2
NextProtO43164 [Medical]
TSGene9867
GENETestsPJA2
Target ValidationPJA2
Huge Navigator PJA2 [HugePedia]
snp3D : Map Gene to Disease9867
BioCentury BCIQPJA2
ClinGenPJA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9867
Chemical/Pharm GKB GenePA134873520
Clinical trialPJA2
Miscellaneous
canSAR (ICR)PJA2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePJA2
EVEXPJA2
GoPubMedPJA2
iHOPPJA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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