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PKDCC (protein kinase domain containing, cytoplasmic)

Identity

Alias_namesprotein kinase domain containing, cytoplasmic homolog (mouse)
Alias_symbol (synonym)SgK493
Vlk
Other aliasSGK493
HGNC (Hugo) PKDCC
LocusID (NCBI) 91461
Atlas_Id 71942
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 42048021 and ends at 42058528 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBE2M (19q13.43) / PKDCC (2p21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PKDCC   25123
Cards
Entrez_Gene (NCBI)PKDCC  91461  protein kinase domain containing, cytoplasmic
AliasesSGK493; Vlk
GeneCards (Weizmann)PKDCC
Ensembl hg19 (Hinxton)ENSG00000162878 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162878 [Gene_View]  chr2:42048021-42058528 [Contig_View]  PKDCC [Vega]
ICGC DataPortalENSG00000162878
TCGA cBioPortalPKDCC
AceView (NCBI)PKDCC
Genatlas (Paris)PKDCC
WikiGenes91461
SOURCE (Princeton)PKDCC
Genetics Home Reference (NIH)PKDCC
Genomic and cartography
GoldenPath hg38 (UCSC)PKDCC  -     chr2:42048021-42058528 +  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PKDCC  -     2p21   [Description]    (hg19-Feb_2009)
EnsemblPKDCC - 2p21 [CytoView hg19]  PKDCC - 2p21 [CytoView hg38]
Mapping of homologs : NCBIPKDCC [Mapview hg19]  PKDCC [Mapview hg38]
OMIM614150   
Gene and transcription
Genbank (Entrez)AK311155 BC007901 BC062988 BC094697 BC110513
RefSeq transcript (Entrez)NM_138370
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PKDCC
Cluster EST : UnigeneHs.408542 [ NCBI ]
CGAP (NCI)Hs.408542
Alternative Splicing GalleryENSG00000162878
Gene ExpressionPKDCC [ NCBI-GEO ]   PKDCC [ EBI - ARRAY_EXPRESS ]   PKDCC [ SEEK ]   PKDCC [ MEM ]
Gene Expression Viewer (FireBrowse)PKDCC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91461
GTEX Portal (Tissue expression)PKDCC
Human Protein AtlasENSG00000162878-PKDCC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ504Y2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ504Y2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ504Y2
Splice isoforms : SwissVarQ504Y2
PhosPhoSitePlusQ504Y2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)FAM69_kinase_dom    Kinase-like_dom    Prot_kinase_dom   
Domain families : Pfam (Sanger)PIP49_C (PF12260)   
Domain families : Pfam (NCBI)pfam12260   
Conserved Domain (NCBI)PKDCC
DMDM Disease mutations91461
Blocks (Seattle)PKDCC
SuperfamilyQ504Y2
Human Protein Atlas [tissue]ENSG00000162878-PKDCC [tissue]
Peptide AtlasQ504Y2
HPRD18707
IPIIPI00014629   IPI00976745   IPI00924909   
Protein Interaction databases
DIP (DOE-UCLA)Q504Y2
IntAct (EBI)Q504Y2
FunCoupENSG00000162878
BioGRIDPKDCC
STRING (EMBL)PKDCC
ZODIACPKDCC
Ontologies - Pathways
QuickGOQ504Y2
Ontology : AmiGOskeletal system development  protein kinase activity  non-membrane spanning protein tyrosine kinase activity  ATP binding  extracellular region  Golgi apparatus  protein transport  peptidyl-tyrosine phosphorylation  cell differentiation  bone mineralization  positive regulation of bone mineralization  positive regulation of chondrocyte differentiation  limb morphogenesis  multicellular organism growth  negative regulation of Golgi to plasma membrane protein transport  lung alveolus development  embryonic digestive tract development  palate development  
Ontology : EGO-EBIskeletal system development  protein kinase activity  non-membrane spanning protein tyrosine kinase activity  ATP binding  extracellular region  Golgi apparatus  protein transport  peptidyl-tyrosine phosphorylation  cell differentiation  bone mineralization  positive regulation of bone mineralization  positive regulation of chondrocyte differentiation  limb morphogenesis  multicellular organism growth  negative regulation of Golgi to plasma membrane protein transport  lung alveolus development  embryonic digestive tract development  palate development  
NDEx NetworkPKDCC
Atlas of Cancer Signalling NetworkPKDCC
Wikipedia pathwaysPKDCC
Orthology - Evolution
OrthoDB91461
GeneTree (enSembl)ENSG00000162878
Phylogenetic Trees/Animal Genes : TreeFamPKDCC
HOVERGENQ504Y2
HOGENOMQ504Y2
Homologs : HomoloGenePKDCC
Homology/Alignments : Family Browser (UCSC)PKDCC
Gene fusions - Rearrangements
Tumor Fusion PortalPKDCC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPKDCC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PKDCC
dbVarPKDCC
ClinVarPKDCC
1000_GenomesPKDCC 
Exome Variant ServerPKDCC
ExAC (Exome Aggregation Consortium)ENSG00000162878
GNOMAD BrowserENSG00000162878
Genetic variants : HAPMAP91461
Genomic Variants (DGV)PKDCC [DGVbeta]
DECIPHERPKDCC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPKDCC 
Mutations
ICGC Data PortalPKDCC 
TCGA Data PortalPKDCC 
Broad Tumor PortalPKDCC
OASIS PortalPKDCC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKDCC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPKDCC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PKDCC
DgiDB (Drug Gene Interaction Database)PKDCC
DoCM (Curated mutations)PKDCC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKDCC (select a term)
intoGenPKDCC
Cancer3DPKDCC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614150   
Orphanet
DisGeNETPKDCC
MedgenPKDCC
Genetic Testing Registry PKDCC
NextProtQ504Y2 [Medical]
TSGene91461
GENETestsPKDCC
Target ValidationPKDCC
Huge Navigator PKDCC [HugePedia]
snp3D : Map Gene to Disease91461
BioCentury BCIQPKDCC
ClinGenPKDCC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91461
Chemical/Pharm GKB GenePA165697259
Clinical trialPKDCC
Miscellaneous
canSAR (ICR)PKDCC (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePKDCC
EVEXPKDCC
GoPubMedPKDCC
iHOPPKDCC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:06:01 CET 2017

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