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PKIA (cAMP-dependent protein kinase inhibitor alpha)

Identity

Alias_namesPRKACN1
Other alias
HGNC (Hugo) PKIA
LocusID (NCBI) 5569
Atlas_Id 54538
Location 8q21.13  [Link to chromosome band 8q21]
Location_base_pair Starts at 78516101 and ends at 78605267 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RARA (17q21.2) / PKIA (8q21.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PKIA   9017
Cards
Entrez_Gene (NCBI)PKIA  5569  cAMP-dependent protein kinase inhibitor alpha
AliasesPRKACN1
GeneCards (Weizmann)PKIA
Ensembl hg19 (Hinxton)ENSG00000171033 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171033 [Gene_View]  chr8:78516101-78605267 [Contig_View]  PKIA [Vega]
ICGC DataPortalENSG00000171033
TCGA cBioPortalPKIA
AceView (NCBI)PKIA
Genatlas (Paris)PKIA
WikiGenes5569
SOURCE (Princeton)PKIA
Genetics Home Reference (NIH)PKIA
Genomic and cartography
GoldenPath hg38 (UCSC)PKIA  -     chr8:78516101-78605267 +  8q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PKIA  -     8q21.13   [Description]    (hg19-Feb_2009)
EnsemblPKIA - 8q21.13 [CytoView hg19]  PKIA - 8q21.13 [CytoView hg38]
Mapping of homologs : NCBIPKIA [Mapview hg19]  PKIA [Mapview hg38]
OMIM606059   
Gene and transcription
Genbank (Entrez)AA644101 AK311857 BC022265 BI597731 BX419914
RefSeq transcript (Entrez)NM_006823 NM_181839
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PKIA
Cluster EST : UnigeneHs.732129 [ NCBI ]
CGAP (NCI)Hs.732129
Alternative Splicing GalleryENSG00000171033
Gene ExpressionPKIA [ NCBI-GEO ]   PKIA [ EBI - ARRAY_EXPRESS ]   PKIA [ SEEK ]   PKIA [ MEM ]
Gene Expression Viewer (FireBrowse)PKIA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5569
GTEX Portal (Tissue expression)PKIA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61925   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61925  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61925
Splice isoforms : SwissVarP61925
PhosPhoSitePlusP61925
Domains : Interpro (EBI)cAMP_dep_PKI   
Domain families : Pfam (Sanger)PKI (PF02827)   
Domain families : Pfam (NCBI)pfam02827   
Domain structure : Prodom (Prabi Lyon)cAMP_dep_PKI (PD010366)   
Conserved Domain (NCBI)PKIA
DMDM Disease mutations5569
Blocks (Seattle)PKIA
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP61925
Human Protein AtlasENSG00000171033
Peptide AtlasP61925
HPRD05828
IPIIPI00220907   
Protein Interaction databases
DIP (DOE-UCLA)P61925
IntAct (EBI)P61925
FunCoupENSG00000171033
BioGRIDPKIA
STRING (EMBL)PKIA
ZODIACPKIA
Ontologies - Pathways
QuickGOP61925
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  cAMP-dependent protein kinase inhibitor activity  cAMP-dependent protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  regulation of G2/M transition of mitotic cell cycle  protein kinase A catalytic subunit binding  negative regulation of protein import into nucleus  negative regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  cAMP-dependent protein kinase inhibitor activity  cAMP-dependent protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  regulation of G2/M transition of mitotic cell cycle  protein kinase A catalytic subunit binding  negative regulation of protein import into nucleus  negative regulation of cAMP-dependent protein kinase activity  
Pathways : KEGGAlcoholism   
NDEx NetworkPKIA
Atlas of Cancer Signalling NetworkPKIA
Wikipedia pathwaysPKIA
Orthology - Evolution
OrthoDB5569
GeneTree (enSembl)ENSG00000171033
Phylogenetic Trees/Animal Genes : TreeFamPKIA
HOVERGENP61925
HOGENOMP61925
Homologs : HomoloGenePKIA
Homology/Alignments : Family Browser (UCSC)PKIA
Gene fusions - Rearrangements
Fusion : MitelmanRARA/PKIA [17q21.2/8q21.12]  [t(8;17)(q21;q21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPKIA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PKIA
dbVarPKIA
ClinVarPKIA
1000_GenomesPKIA 
Exome Variant ServerPKIA
ExAC (Exome Aggregation Consortium)PKIA (select the gene name)
Genetic variants : HAPMAP5569
Genomic Variants (DGV)PKIA [DGVbeta]
DECIPHERPKIA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPKIA 
Mutations
ICGC Data PortalPKIA 
TCGA Data PortalPKIA 
Broad Tumor PortalPKIA
OASIS PortalPKIA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKIA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPKIA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PKIA
DgiDB (Drug Gene Interaction Database)PKIA
DoCM (Curated mutations)PKIA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKIA (select a term)
intoGenPKIA
Cancer3DPKIA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606059   
Orphanet
MedgenPKIA
Genetic Testing Registry PKIA
NextProtP61925 [Medical]
TSGene5569
GENETestsPKIA
Huge Navigator PKIA [HugePedia]
snp3D : Map Gene to Disease5569
BioCentury BCIQPKIA
ClinGenPKIA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5569
Chemical/Pharm GKB GenePA33349
Clinical trialPKIA
Miscellaneous
canSAR (ICR)PKIA (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePKIA
EVEXPKIA
GoPubMedPKIA
iHOPPKIA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:24 CEST 2017

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