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PKIB (cAMP-dependent protein kinase inhibitor beta)

Identity

Alias_namesPRKACN2
Other alias
HGNC (Hugo) PKIB
LocusID (NCBI) 5570
Atlas_Id 41727
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 122610232 and ends at 122726373 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGA1 (5q11.2) / PKIB (6q22.31)PATZ1 (22q12.2) / PKIB (6q22.31)PKIB (6q22.31) / SLC35F1 (6q22.1)
PATZ1 22q12.2 / PKIB 6q22.31PKIB 6q22.31 / SLC35F1 6q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  PKIB/SLC35F1 (6q22)
t(6;22)(q22;q12) PATZ1/PKIB


External links

Nomenclature
HGNC (Hugo)PKIB   9018
Cards
Entrez_Gene (NCBI)PKIB  5570  cAMP-dependent protein kinase inhibitor beta
AliasesPRKACN2
GeneCards (Weizmann)PKIB
Ensembl hg19 (Hinxton)ENSG00000135549 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135549 [Gene_View]  ENSG00000135549 [Sequence]  chr6:122610232-122726373 [Contig_View]  PKIB [Vega]
ICGC DataPortalENSG00000135549
TCGA cBioPortalPKIB
AceView (NCBI)PKIB
Genatlas (Paris)PKIB
WikiGenes5570
SOURCE (Princeton)PKIB
Genetics Home Reference (NIH)PKIB
Genomic and cartography
GoldenPath hg38 (UCSC)PKIB  -     chr6:122610232-122726373 +  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PKIB  -     6q22.31   [Description]    (hg19-Feb_2009)
EnsemblPKIB - 6q22.31 [CytoView hg19]  PKIB - 6q22.31 [CytoView hg38]
Mapping of homologs : NCBIPKIB [Mapview hg19]  PKIB [Mapview hg38]
OMIM606914   
Gene and transcription
Genbank (Entrez)AF087873 AF225513 AJ420562 AK074397 AK315151
RefSeq transcript (Entrez)NM_001270393 NM_001270394 NM_001270395 NM_032471 NM_181794 NM_181795
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PKIB
Cluster EST : UnigeneHs.744965 [ NCBI ]
CGAP (NCI)Hs.744965
Alternative Splicing GalleryENSG00000135549
Gene ExpressionPKIB [ NCBI-GEO ]   PKIB [ EBI - ARRAY_EXPRESS ]   PKIB [ SEEK ]   PKIB [ MEM ]
Gene Expression Viewer (FireBrowse)PKIB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5570
GTEX Portal (Tissue expression)PKIB
Human Protein AtlasENSG00000135549-PKIB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C010   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C010  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C010
Splice isoforms : SwissVarQ9C010
PhosPhoSitePlusQ9C010
Domains : Interpro (EBI)cAMP_dep_PKI   
Domain families : Pfam (Sanger)PKI (PF02827)   
Domain families : Pfam (NCBI)pfam02827   
Domain structure : Prodom (Prabi Lyon)cAMP_dep_PKI (PD010366)   
Conserved Domain (NCBI)PKIB
DMDM Disease mutations5570
Blocks (Seattle)PKIB
SuperfamilyQ9C010
Human Protein Atlas [tissue]ENSG00000135549-PKIB [tissue]
Peptide AtlasQ9C010
HPRD06075
IPIIPI00032472   IPI00643303   IPI00646187   
Protein Interaction databases
DIP (DOE-UCLA)Q9C010
IntAct (EBI)Q9C010
FunCoupENSG00000135549
BioGRIDPKIB
STRING (EMBL)PKIB
ZODIACPKIB
Ontologies - Pathways
QuickGOQ9C010
Ontology : AmiGOcAMP-dependent protein kinase inhibitor activity  nucleus  cytoplasm  positive regulation of telomere maintenance via telomerase  positive regulation of telomerase activity  positive regulation of telomere capping  negative regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBIcAMP-dependent protein kinase inhibitor activity  nucleus  cytoplasm  positive regulation of telomere maintenance via telomerase  positive regulation of telomerase activity  positive regulation of telomere capping  negative regulation of cAMP-dependent protein kinase activity  
NDEx NetworkPKIB
Atlas of Cancer Signalling NetworkPKIB
Wikipedia pathwaysPKIB
Orthology - Evolution
OrthoDB5570
GeneTree (enSembl)ENSG00000135549
Phylogenetic Trees/Animal Genes : TreeFamPKIB
HOVERGENQ9C010
HOGENOMQ9C010
Homologs : HomoloGenePKIB
Homology/Alignments : Family Browser (UCSC)PKIB
Gene fusions - Rearrangements
Fusion : MitelmanPATZ1/PKIB [22q12.2/6q22.31]  [t(6;22)(q22;q12)]  
Fusion : MitelmanPKIB/SLC35F1 [6q22.31/6q22.1]  [t(6;6)(q22;q22)]  
Fusion PortalPATZ1 22q12.2 PKIB 6q22.31 BRCA
Fusion PortalPKIB 6q22.31 SLC35F1 6q22.1 BRCA
Fusion : QuiverPKIB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPKIB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PKIB
dbVarPKIB
ClinVarPKIB
1000_GenomesPKIB 
Exome Variant ServerPKIB
ExAC (Exome Aggregation Consortium)ENSG00000135549
GNOMAD BrowserENSG00000135549
Varsome BrowserPKIB
Genetic variants : HAPMAP5570
Genomic Variants (DGV)PKIB [DGVbeta]
DECIPHERPKIB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPKIB 
Mutations
ICGC Data PortalPKIB 
TCGA Data PortalPKIB 
Broad Tumor PortalPKIB
OASIS PortalPKIB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKIB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPKIB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PKIB
DgiDB (Drug Gene Interaction Database)PKIB
DoCM (Curated mutations)PKIB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKIB (select a term)
intoGenPKIB
Cancer3DPKIB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606914   
Orphanet
DisGeNETPKIB
MedgenPKIB
Genetic Testing Registry PKIB
NextProtQ9C010 [Medical]
TSGene5570
GENETestsPKIB
Target ValidationPKIB
Huge Navigator PKIB [HugePedia]
snp3D : Map Gene to Disease5570
BioCentury BCIQPKIB
ClinGenPKIB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5570
Chemical/Pharm GKB GenePA33350
Clinical trialPKIB
Miscellaneous
canSAR (ICR)PKIB (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePKIB
EVEXPKIB
GoPubMedPKIB
iHOPPKIB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:30:16 CET 2018

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