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PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)

Identity

Alias_symbol (synonym)MYT1
PPP1R126
Other alias
HGNC (Hugo) PKMYT1
LocusID (NCBI) 9088
Atlas_Id 43411
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 3022792 and ends at 3030540 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANKRD10 (13q34) / PKMYT1 (16p13.3)PKMYT1 (16p13.3) / CLDN6 (16p13.3)PKMYT1 (16p13.3) / PAQR4 (16p13.3)
PKMYT1 (16p13.3) / TMEM203 (9q34.3)PKMYT1 16p13.3 / CLDN6 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PKMYT1   29650
Cards
Entrez_Gene (NCBI)PKMYT1  9088  protein kinase, membrane associated tyrosine/threonine 1
AliasesMYT1; PPP1R126
GeneCards (Weizmann)PKMYT1
Ensembl hg19 (Hinxton)ENSG00000127564 [Gene_View]  chr16:3022792-3030540 [Contig_View]  PKMYT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000127564 [Gene_View]  chr16:3022792-3030540 [Contig_View]  PKMYT1 [Vega]
ICGC DataPortalENSG00000127564
TCGA cBioPortalPKMYT1
AceView (NCBI)PKMYT1
Genatlas (Paris)PKMYT1
WikiGenes9088
SOURCE (Princeton)PKMYT1
Genetics Home Reference (NIH)PKMYT1
Genomic and cartography
GoldenPath hg19 (UCSC)PKMYT1  -     chr16:3022792-3030540 -  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PKMYT1  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblPKMYT1 - 16p13.3 [CytoView hg19]  PKMYT1 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIPKMYT1 [Mapview hg19]  PKMYT1 [Mapview hg38]
OMIM602474   
Gene and transcription
Genbank (Entrez)AK097642 AK098452 AK294379 AK301926 AK303005
RefSeq transcript (Entrez)NM_001258450 NM_001258451 NM_004203 NM_182687
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)PKMYT1
Cluster EST : UnigeneHs.732385 [ NCBI ]
CGAP (NCI)Hs.732385
Alternative Splicing GalleryENSG00000127564
Gene ExpressionPKMYT1 [ NCBI-GEO ]   PKMYT1 [ EBI - ARRAY_EXPRESS ]   PKMYT1 [ SEEK ]   PKMYT1 [ MEM ]
Gene Expression Viewer (FireBrowse)PKMYT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9088
GTEX Portal (Tissue expression)PKMYT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99640   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99640  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99640
Splice isoforms : SwissVarQ99640
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ99640
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Tyr/Thr_kinase_Cdc2_inhib   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)PKMYT1
DMDM Disease mutations9088
Blocks (Seattle)PKMYT1
PDB (SRS)3P1A   
PDB (PDBSum)3P1A   
PDB (IMB)3P1A   
PDB (RSDB)3P1A   
Structural Biology KnowledgeBase3P1A   
SCOP (Structural Classification of Proteins)3P1A   
CATH (Classification of proteins structures)3P1A   
SuperfamilyQ99640
Human Protein AtlasENSG00000127564
Peptide AtlasQ99640
HPRD03920
IPIIPI00384765   IPI00939425   IPI00909627   IPI01011697   IPI00377017   
Protein Interaction databases
DIP (DOE-UCLA)Q99640
IntAct (EBI)Q99640
FunCoupENSG00000127564
BioGRIDPKMYT1
STRING (EMBL)PKMYT1
ZODIACPKMYT1
Ontologies - Pathways
QuickGOQ99640
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  Golgi membrane  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  protein phosphorylation  mitotic nuclear division  regulation of mitotic nuclear division  negative regulation of phosphatase activity  membrane  kinase activity  kinase activity  metal ion binding  regulation of cell cycle  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  Golgi membrane  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  protein phosphorylation  mitotic nuclear division  regulation of mitotic nuclear division  negative regulation of phosphatase activity  membrane  kinase activity  kinase activity  metal ion binding  regulation of cell cycle  
Pathways : KEGGCell cycle    Oocyte meiosis    Progesterone-mediated oocyte maturation   
NDEx NetworkPKMYT1
Atlas of Cancer Signalling NetworkPKMYT1
Wikipedia pathwaysPKMYT1
Orthology - Evolution
OrthoDB9088
GeneTree (enSembl)ENSG00000127564
Phylogenetic Trees/Animal Genes : TreeFamPKMYT1
HOVERGENQ99640
HOGENOMQ99640
Homologs : HomoloGenePKMYT1
Homology/Alignments : Family Browser (UCSC)PKMYT1
Gene fusions - Rearrangements
Fusion : MitelmanPKMYT1/CLDN6 [16p13.3/16p13.3]  
Fusion: TCGAPKMYT1 16p13.3 CLDN6 16p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPKMYT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PKMYT1
dbVarPKMYT1
ClinVarPKMYT1
1000_GenomesPKMYT1 
Exome Variant ServerPKMYT1
ExAC (Exome Aggregation Consortium)PKMYT1 (select the gene name)
Genetic variants : HAPMAP9088
Genomic Variants (DGV)PKMYT1 [DGVbeta]
DECIPHER (Syndromes)16:3022792-3030540  ENSG00000127564
CONAN: Copy Number AnalysisPKMYT1 
Mutations
ICGC Data PortalPKMYT1 
TCGA Data PortalPKMYT1 
Broad Tumor PortalPKMYT1
OASIS PortalPKMYT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKMYT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPKMYT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PKMYT1
DgiDB (Drug Gene Interaction Database)PKMYT1
DoCM (Curated mutations)PKMYT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKMYT1 (select a term)
intoGenPKMYT1
Cancer3DPKMYT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602474   
Orphanet
MedgenPKMYT1
Genetic Testing Registry PKMYT1
NextProtQ99640 [Medical]
TSGene9088
GENETestsPKMYT1
Huge Navigator PKMYT1 [HugePedia]
snp3D : Map Gene to Disease9088
BioCentury BCIQPKMYT1
ClinGenPKMYT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9088
Chemical/Pharm GKB GenePA385
Clinical trialPKMYT1
Miscellaneous
canSAR (ICR)PKMYT1 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePKMYT1
EVEXPKMYT1
GoPubMedPKMYT1
iHOPPKMYT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:31 CEST 2017

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