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PKN2 (protein kinase N2)

Identity

Alias (NCBI)PAK2
PRK2
PRKCL2
PRO2042
Pak-2
STK7
HGNC (Hugo) PKN2
HGNC Alias symbPRK2
Pak-2
STK7
HGNC Alias namecardiolipin-activated protein kinase Pak2
HGNC Previous namePRKCL2
HGNC Previous nameprotein kinase C-like 2
LocusID (NCBI) 5586
Atlas_Id 41859
Location 1p22.2  [Link to chromosome band 1p22]
Location_base_pair Starts at 88684273 and ends at 88836255 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DMTN (8p21.3) / PKN2 (1p22.2)PKN2 (1p22.2) / COL24A1 (1p22.3)PKN2 (1p22.2) / FASTKD1 (2q31.1)
PKN2 (1p22.2) / TXK (4p12)PKN2 1p22.2 / COL24A1 1p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PKN2/COL24A1 (1p22)

External links

Nomenclature
HGNC (Hugo)PKN2   9406
Cards
Entrez_Gene (NCBI)PKN2    protein kinase N2
AliasesPAK2; PRK2; PRKCL2; PRO2042; 
Pak-2; STK7
GeneCards (Weizmann)PKN2
Ensembl hg19 (Hinxton)ENSG00000065243 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065243 [Gene_View]  ENSG00000065243 [Sequence]  chr1:88684273-88836255 [Contig_View]  PKN2 [Vega]
ICGC DataPortalENSG00000065243
TCGA cBioPortalPKN2
AceView (NCBI)PKN2
Genatlas (Paris)PKN2
SOURCE (Princeton)PKN2
Genetics Home Reference (NIH)PKN2
Genomic and cartography
GoldenPath hg38 (UCSC)PKN2  -     chr1:88684273-88836255 +  1p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PKN2  -     1p22.2   [Description]    (hg19-Feb_2009)
GoldenPathPKN2 - 1p22.2 [CytoView hg19]  PKN2 - 1p22.2 [CytoView hg38]
ImmunoBaseENSG00000065243
genome Data Viewer NCBIPKN2 [Mapview hg19]  
OMIM602549   
Gene and transcription
Genbank (Entrez)AF118089 AK023692 AK298595 AK300304 AK301066
RefSeq transcript (Entrez)NM_001320707 NM_001320708 NM_001320709 NM_006256
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PKN2
Alternative Splicing GalleryENSG00000065243
Gene ExpressionPKN2 [ NCBI-GEO ]   PKN2 [ EBI - ARRAY_EXPRESS ]   PKN2 [ SEEK ]   PKN2 [ MEM ]
Gene Expression Viewer (FireBrowse)PKN2 [ Firebrowse - Broad ]
GenevisibleExpression of PKN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5586
GTEX Portal (Tissue expression)PKN2
Human Protein AtlasENSG00000065243-PKN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16513   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16513  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16513
Splice isoforms : SwissVarQ16513
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ16513
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    REM_1 (PS51860)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    C2_PKN    HR1_rho-bd    HR1_rpt_sf    Kinase-like_dom_sf    Pkinase_C    PKN_HR1_1    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)HR1 (PF02185)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam02185    pfam00069    pfam00433   
Domain families : Smart (EMBL)C2 (SM00239)  Hr1 (SM00742)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PKN2
Blocks (Seattle)PKN2
PDB (RSDB)4CRS    4RRV    6CCY    6GBE   
PDB Europe4CRS    4RRV    6CCY    6GBE   
PDB (PDBSum)4CRS    4RRV    6CCY    6GBE   
PDB (IMB)4CRS    4RRV    6CCY    6GBE   
Structural Biology KnowledgeBase4CRS    4RRV    6CCY    6GBE   
SCOP (Structural Classification of Proteins)4CRS    4RRV    6CCY    6GBE   
CATH (Classification of proteins structures)4CRS    4RRV    6CCY    6GBE   
SuperfamilyQ16513
Human Protein Atlas [tissue]ENSG00000065243-PKN2 [tissue]
Peptide AtlasQ16513
HPRD03972
IPIIPI00002804   IPI01013829   IPI00514557   IPI01014646   IPI00745366   IPI00005990   IPI00514041   IPI01018651   
Protein Interaction databases
DIP (DOE-UCLA)Q16513
IntAct (EBI)Q16513
BioGRIDPKN2
STRING (EMBL)PKN2
ZODIACPKN2
Ontologies - Pathways
QuickGOQ16513
Ontology : AmiGORNA binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calcium-dependent protein kinase C activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  centrosome  cytosol  cytosol  plasma membrane  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  epithelial cell migration  viral process  kinase activity  nuclear body  GTP-Rho binding  peptidyl-serine phosphorylation  lamellipodium  cell projection organization  midbody  cleavage furrow  positive regulation of cytokinesis  protein-containing complex  intracellular signal transduction  histone deacetylase binding  apical junction complex  apical junction assembly  positive regulation of viral genome replication  intermediate filament cytoskeleton  cadherin binding  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  cell division  RNA polymerase binding  regulation of cell motility  
Ontology : EGO-EBIRNA binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calcium-dependent protein kinase C activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  centrosome  cytosol  cytosol  plasma membrane  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  epithelial cell migration  viral process  kinase activity  nuclear body  GTP-Rho binding  peptidyl-serine phosphorylation  lamellipodium  cell projection organization  midbody  cleavage furrow  positive regulation of cytokinesis  protein-containing complex  intracellular signal transduction  histone deacetylase binding  apical junction complex  apical junction assembly  positive regulation of viral genome replication  intermediate filament cytoskeleton  cadherin binding  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  cell division  RNA polymerase binding  regulation of cell motility  
Pathways : KEGGPI3K-Akt signaling pathway    Salmonella infection   
NDEx NetworkPKN2
Atlas of Cancer Signalling NetworkPKN2
Wikipedia pathwaysPKN2
Orthology - Evolution
OrthoDB5586
GeneTree (enSembl)ENSG00000065243
Phylogenetic Trees/Animal Genes : TreeFamPKN2
HOGENOMQ16513
Homologs : HomoloGenePKN2
Homology/Alignments : Family Browser (UCSC)PKN2
Gene fusions - Rearrangements
Fusion : MitelmanPKN2/COL24A1 [1p22.2/1p22.3]  
Fusion PortalPKN2 1p22.2 COL24A1 1p22.3 BRCA
Fusion : QuiverPKN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPKN2 [hg38]
dbVarPKN2
ClinVarPKN2
MonarchPKN2
1000_GenomesPKN2 
Exome Variant ServerPKN2
GNOMAD BrowserENSG00000065243
Varsome BrowserPKN2
Genomic Variants (DGV)PKN2 [DGVbeta]
DECIPHERPKN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPKN2 
Mutations
ICGC Data PortalPKN2 
TCGA Data PortalPKN2 
Broad Tumor PortalPKN2
OASIS PortalPKN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPKN2
Mutations and Diseases : HGMDPKN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PKN2
DgiDB (Drug Gene Interaction Database)PKN2
DoCM (Curated mutations)PKN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKN2 (select a term)
intoGenPKN2
Cancer3DPKN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602549   
Orphanet
DisGeNETPKN2
MedgenPKN2
Genetic Testing Registry PKN2
NextProtQ16513 [Medical]
GENETestsPKN2
Target ValidationPKN2
Huge Navigator PKN2 [HugePedia]
ClinGenPKN2
Clinical trials, drugs, therapy
MyCancerGenomePKN2
Protein Interactions : CTD
Pharm GKB GenePA33770
PharosQ16513
Clinical trialPKN2
Miscellaneous
canSAR (ICR)PKN2 (select the gene name)
HarmonizomePKN2
DataMed IndexPKN2
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPKN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:31:38 CET 2021
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