Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PKN2 (protein kinase N2)

Identity

Other namesPAK2
PRK2
PRKCL2
PRO2042
Pak-2
STK7
HGNC (Hugo) PKN2
LocusID (NCBI) 5586
Location 1p22.2
Location_base_pair Starts at 89149922 and ends at 89301938 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PKN2   9406
Cards
Entrez_Gene (NCBI)PKN2  5586  protein kinase N2
GeneCards (Weizmann)PKN2
Ensembl (Hinxton)ENSG00000065243 [Gene_View]  chr1:89149922-89301938 [Contig_View]  PKN2 [Vega]
ICGC DataPortalENSG00000065243
cBioPortalPKN2
AceView (NCBI)PKN2
Genatlas (Paris)PKN2
WikiGenes5586
SOURCE (Princeton)NM_006256
Genomic and cartography
GoldenPath (UCSC)PKN2  -  1p22.2   chr1:89149922-89301938 +  1p22.2   [Description]    (hg19-Feb_2009)
EnsemblPKN2 - 1p22.2 [CytoView]
Mapping of homologs : NCBIPKN2 [Mapview]
OMIM602549   
Gene and transcription
Genbank (Entrez)AF118089 AK023692 AK298595 AK300304 AK301066
RefSeq transcript (Entrez)NM_006256
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_032977 NW_001838589 NW_004929290
Consensus coding sequences : CCDS (NCBI)PKN2
Cluster EST : UnigeneHs.440833 [ NCBI ]
CGAP (NCI)Hs.440833
Alternative Splicing : Fast-db (Paris)GSHG0045800
Alternative Splicing GalleryENSG00000065243
Gene ExpressionPKN2 [ NCBI-GEO ]     PKN2 [ SEEK ]   PKN2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16513 (Uniprot)
NextProtQ16513  [Medical]
With graphics : InterProQ16513
Splice isoforms : SwissVarQ16513 (Swissvar)
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C [organisation]   C2_dom [organisation]   HR1_rho-bd [organisation]   Kinase-like_dom [organisation]   Pkinase_C [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrQ16513
Domain families : Pfam (Sanger)HR1 (PF02185)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam02185    pfam00069    pfam00433   
Domain families : Smart (EMBL)C2 (SM00239)  Hr1 (SM00742)  S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations5586
Blocks (Seattle)Q16513
PDB (SRS)4CRS   
PDB (PDBSum)4CRS   
PDB (IMB)4CRS   
PDB (RSDB)4CRS   
Human Protein AtlasENSG00000065243 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ16513
HPRD03972
IPIIPI00002804   IPI01013829   IPI00514557   IPI01014646   IPI00745366   IPI00005990   IPI00514041   IPI01018651   
Protein Interaction databases
DIP (DOE-UCLA)Q16513
IntAct (EBI)Q16513
FunCoupENSG00000065243
BioGRIDPKN2
InParanoidQ16513
Interologous Interaction database Q16513
IntegromeDBPKN2
STRING (EMBL)PKN2
Ontologies - Pathways
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleus  nucleolus  cytoplasm  centrosome  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  epithelial cell migration  membrane  lamellipodium  midbody  cleavage furrow  positive regulation of cytokinesis  histone deacetylase binding  apical junction complex  apical junction assembly  poly(A) RNA binding  intermediate filament cytoskeleton  positive regulation of mitotic cell cycle  cell division  regulation of cell motility  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleus  nucleolus  cytoplasm  centrosome  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  epithelial cell migration  membrane  lamellipodium  midbody  cleavage furrow  positive regulation of cytokinesis  histone deacetylase binding  apical junction complex  apical junction assembly  poly(A) RNA binding  intermediate filament cytoskeleton  positive regulation of mitotic cell cycle  cell division  regulation of cell motility  
Pathways : KEGGPI3K-Akt signaling pathway    Salmonella infection   
Protein Interaction DatabasePKN2
Wikipedia pathwaysPKN2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PKN2
snp3D : Map Gene to Disease5586
SNP (GeneSNP Utah)PKN2
SNP : HGBasePKN2
Genetic variants : HAPMAPPKN2
Exome VariantPKN2
1000_GenomesPKN2 
ICGC programENSG00000065243 
Somatic Mutations in Cancer : COSMICPKN2 
CONAN: Copy Number AnalysisPKN2 
Mutations and Diseases : HGMDPKN2
Mutations and Diseases : intOGenPKN2
Genomic VariantsPKN2  PKN2 [DGVbeta]
dbVarPKN2
ClinVarPKN2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602549   
MedgenPKN2
GENETestsPKN2
Disease Genetic AssociationPKN2
Huge Navigator PKN2 [HugePedia]  PKN2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePKN2
Homology/Alignments : Family Browser (UCSC)PKN2
Phylogenetic Trees/Animal Genes : TreeFamPKN2
Chemical/Protein Interactions : CTD5586
Chemical/Pharm GKB GenePA33770
Clinical trialPKN2
Cancer Resource (Charite)ENSG00000065243
Other databases
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
CoreMinePKN2
iHOPPKN2
OncoSearchPKN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:59:53 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.