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PKN2 (protein kinase N2)

Identity

Other namesPAK2
PRK2
PRKCL2
PRO2042
Pak-2
STK7
HGNC (Hugo) PKN2
LocusID (NCBI) 5586
Atlas_Id 41859
Location 1p22.2  [Link to chromosome band 1p22]
Location_base_pair Starts at 89149922 and ends at 89301938 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DMTN (8p21.3) / PKN2 (1p22.2)PKN2 (1p22.2) / COL24A1 (1p22.3)PKN2 (1p22.2) / FASTKD1 (2q31.1)
PKN2 (1p22.2) / TXK (4p12)PKN2 1p22.2 / COL24A1 1p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PKN2   9406
Cards
Entrez_Gene (NCBI)PKN2  5586  protein kinase N2
AliasesPAK2; PRK2; PRKCL2; PRO2042; 
Pak-2; STK7
GeneCards (Weizmann)PKN2
Ensembl hg19 (Hinxton)ENSG00000065243 [Gene_View]  chr1:89149922-89301938 [Contig_View]  PKN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000065243 [Gene_View]  chr1:89149922-89301938 [Contig_View]  PKN2 [Vega]
ICGC DataPortalENSG00000065243
TCGA cBioPortalPKN2
AceView (NCBI)PKN2
Genatlas (Paris)PKN2
WikiGenes5586
SOURCE (Princeton)PKN2
Genomic and cartography
GoldenPath hg19 (UCSC)PKN2  -     chr1:89149922-89301938 +  1p22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PKN2  -     1p22.2   [Description]    (hg38-Dec_2013)
EnsemblPKN2 - 1p22.2 [CytoView hg19]  PKN2 - 1p22.2 [CytoView hg38]
Mapping of homologs : NCBIPKN2 [Mapview hg19]  PKN2 [Mapview hg38]
OMIM602549   
Gene and transcription
Genbank (Entrez)AF118089 AK023692 AK298595 AK300304 AK301066
RefSeq transcript (Entrez)NM_001320707 NM_001320708 NM_001320709 NM_006256
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)PKN2
Cluster EST : UnigeneHs.440833 [ NCBI ]
CGAP (NCI)Hs.440833
Alternative Splicing GalleryENSG00000065243
Gene ExpressionPKN2 [ NCBI-GEO ]   PKN2 [ EBI - ARRAY_EXPRESS ]   PKN2 [ SEEK ]   PKN2 [ MEM ]
Gene Expression Viewer (FireBrowse)PKN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5586
GTEX Portal (Tissue expression)PKN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16513 (Uniprot)
NextProtQ16513  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16513
Splice isoforms : SwissVarQ16513 (Swissvar)
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
PhosPhoSitePlusQ16513
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    HR1_rho-bd    Kinase-like_dom    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)HR1 (PF02185)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam02185    pfam00069    pfam00433   
Domain families : Smart (EMBL)C2 (SM00239)  Hr1 (SM00742)  S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations5586
Blocks (Seattle)PKN2
PDB (SRS)4CRS    4RRV   
PDB (PDBSum)4CRS    4RRV   
PDB (IMB)4CRS    4RRV   
PDB (RSDB)4CRS    4RRV   
Structural Biology KnowledgeBase4CRS    4RRV   
SCOP (Structural Classification of Proteins)4CRS    4RRV   
CATH (Classification of proteins structures)4CRS    4RRV   
SuperfamilyQ16513
Human Protein AtlasENSG00000065243
Peptide AtlasQ16513
HPRD03972
IPIIPI00002804   IPI01013829   IPI00514557   IPI01014646   IPI00745366   IPI00005990   IPI00514041   IPI01018651   
Protein Interaction databases
DIP (DOE-UCLA)Q16513
IntAct (EBI)Q16513
FunCoupENSG00000065243
BioGRIDPKN2
STRING (EMBL)PKN2
ZODIACPKN2
Ontologies - Pathways
QuickGOQ16513
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  centrosome  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  epithelial cell migration  kinase activity  peptidyl-serine phosphorylation  lamellipodium  cell junction  midbody  cleavage furrow  positive regulation of cytokinesis  intracellular signal transduction  histone deacetylase binding  protein complex  apical junction complex  apical junction assembly  poly(A) RNA binding  positive regulation of viral genome replication  intermediate filament cytoskeleton  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  cell division  RNA polymerase binding  regulation of cell motility  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  centrosome  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  epithelial cell migration  kinase activity  peptidyl-serine phosphorylation  lamellipodium  cell junction  midbody  cleavage furrow  positive regulation of cytokinesis  intracellular signal transduction  histone deacetylase binding  protein complex  apical junction complex  apical junction assembly  poly(A) RNA binding  positive regulation of viral genome replication  intermediate filament cytoskeleton  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  cell division  RNA polymerase binding  regulation of cell motility  
Pathways : KEGGPI3K-Akt signaling pathway    Salmonella infection   
NDEx Network
Atlas of Cancer Signalling NetworkPKN2
Wikipedia pathwaysPKN2
Orthology - Evolution
OrthoDB5586
GeneTree (enSembl)ENSG00000065243
Phylogenetic Trees/Animal Genes : TreeFamPKN2
Homologs : HomoloGenePKN2
Homology/Alignments : Family Browser (UCSC)PKN2
Gene fusions - Rearrangements
Fusion: TCGAPKN2 1p22.2 COL24A1 1p22.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPKN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PKN2
dbVarPKN2
ClinVarPKN2
1000_GenomesPKN2 
Exome Variant ServerPKN2
ExAC (Exome Aggregation Consortium)PKN2 (select the gene name)
Genetic variants : HAPMAP5586
Genomic Variants (DGV)PKN2 [DGVbeta]
Mutations
ICGC Data PortalPKN2 
TCGA Data PortalPKN2 
Broad Tumor PortalPKN2
OASIS PortalPKN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKN2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PKN2
DgiDB (Drug Gene Interaction Database)PKN2
DoCM (Curated mutations)PKN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKN2 (select a term)
intoGenPKN2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:89149922-89301938  ENSG00000065243
CONAN: Copy Number AnalysisPKN2 
Mutations and Diseases : HGMDPKN2
OMIM602549   
MedgenPKN2
Genetic Testing Registry PKN2
NextProtQ16513 [Medical]
TSGene5586
GENETestsPKN2
Huge Navigator PKN2 [HugePedia]
snp3D : Map Gene to Disease5586
BioCentury BCIQPKN2
ClinGenPKN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5586
Chemical/Pharm GKB GenePA33770
Clinical trialPKN2
Miscellaneous
canSAR (ICR)PKN2 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePKN2
EVEXPKN2
GoPubMedPKN2
iHOPPKN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:07:44 CEST 2016

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