PLA1A (phospholipase A1 member A)

2015-05-01  

Identity

HGNC
PLA1A
LOCATION
3q13.33
LOCUSID
51365
ALIAS
PS-PLA1,PSPLA1

Other Information

Locus ID:

NCBI: 51365
MIM: 607460
HGNC: 17661
Ensembl: ENSG00000144837

Variants:

dbSNP: 51365
ClinVar: 51365
TCGA: ENSG00000144837
COSMIC: PLA1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144837ENST00000273371Q53H76
ENSG00000144837ENST00000475963H7C4H1
ENSG00000144837ENST00000488919Q53H76
ENSG00000144837ENST00000494440G5E9W0
ENSG00000144837ENST00000495992Q53H76

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ras signaling pathwayKEGGhsa04014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PSREACTOMER-HSA-1482801

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196329842009Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex.22
255050712015Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
248864432014PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort.4
281438942017Analysis of glycero-lysophospholipids in gastric cancerous ascites.4
205732952010Expression of phosphatidylserine-specific phospholipase A(1) mRNA in human THP-1-derived macrophages.3
257502982015Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.3
243682102014Kinetic and structural characterization of triacylglycerol lipases possessing phospholipase A1 activity.2
295008642018Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma.2

Citation

Dessen P

PLA1A (phospholipase A1 member A)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55217/pla1a