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PLA2G12A (phospholipase A2, group XIIA)

Identity

Alias_namesPLA2G12
phospholipase A2, group XII
phospholipase A2, group XIIA
Other aliasGXII
ROSSY
HGNC (Hugo) PLA2G12A
LocusID (NCBI) 81579
Atlas_Id 71950
Location 4q25  [Link to chromosome band 4q25]
Location_base_pair Starts at 110631145 and ends at 110651242 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PLA2G12A (4q25) / CASP6 (4q25)PLA2G12A (4q25) / SCAPER (15q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G12A   18554
Cards
Entrez_Gene (NCBI)PLA2G12A  81579  phospholipase A2, group XIIA
AliasesGXII; PLA2G12; ROSSY
GeneCards (Weizmann)PLA2G12A
Ensembl hg19 (Hinxton)ENSG00000123739 [Gene_View]  chr4:110631145-110651242 [Contig_View]  PLA2G12A [Vega]
Ensembl hg38 (Hinxton)ENSG00000123739 [Gene_View]  chr4:110631145-110651242 [Contig_View]  PLA2G12A [Vega]
ICGC DataPortalENSG00000123739
TCGA cBioPortalPLA2G12A
AceView (NCBI)PLA2G12A
Genatlas (Paris)PLA2G12A
WikiGenes81579
SOURCE (Princeton)PLA2G12A
Genetics Home Reference (NIH)PLA2G12A
Genomic and cartography
GoldenPath hg19 (UCSC)PLA2G12A  -     chr4:110631145-110651242 -  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLA2G12A  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblPLA2G12A - 4q25 [CytoView hg19]  PLA2G12A - 4q25 [CytoView hg38]
Mapping of homologs : NCBIPLA2G12A [Mapview hg19]  PLA2G12A [Mapview hg38]
OMIM611652   
Gene and transcription
Genbank (Entrez)AF306567 AF332892 AK075389 AK313081 AY359024
RefSeq transcript (Entrez)NM_030821
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)PLA2G12A
Cluster EST : UnigeneHs.389452 [ NCBI ]
CGAP (NCI)Hs.389452
Alternative Splicing GalleryENSG00000123739
Gene ExpressionPLA2G12A [ NCBI-GEO ]   PLA2G12A [ EBI - ARRAY_EXPRESS ]   PLA2G12A [ SEEK ]   PLA2G12A [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G12A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81579
GTEX Portal (Tissue expression)PLA2G12A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZM1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZM1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZM1
Splice isoforms : SwissVarQ9BZM1
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ9BZM1
Domaine pattern : Prosite (Expaxy)PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2_AS    PLipase_A2_dom    PLipase_A2_secretory_G12   
Domain families : Pfam (Sanger)PLA2G12 (PF06951)   
Domain families : Pfam (NCBI)pfam06951   
Conserved Domain (NCBI)PLA2G12A
DMDM Disease mutations81579
Blocks (Seattle)PLA2G12A
SuperfamilyQ9BZM1
Human Protein AtlasENSG00000123739
Peptide AtlasQ9BZM1
HPRD17858
IPIIPI00017095   IPI00965562   IPI00964611   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZM1
IntAct (EBI)Q9BZM1
FunCoupENSG00000123739
BioGRIDPLA2G12A
STRING (EMBL)PLA2G12A
ZODIACPLA2G12A
Ontologies - Pathways
QuickGOQ9BZM1
Ontology : AmiGOcalcium ion binding  extracellular region  extracellular region  endoplasmic reticulum  Golgi apparatus  phospholipid metabolic process  phosphatidic acid biosynthetic process  biological_process  lipid catabolic process  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  small molecule metabolic process  glycerophospholipid biosynthetic process  calcium-dependent phospholipase A2 activity  
Ontology : EGO-EBIcalcium ion binding  extracellular region  extracellular region  endoplasmic reticulum  Golgi apparatus  phospholipid metabolic process  phosphatidic acid biosynthetic process  biological_process  lipid catabolic process  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  small molecule metabolic process  glycerophospholipid biosynthetic process  calcium-dependent phospholipase A2 activity  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    Ras signaling pathway    Vascular smooth muscle contraction    Pancreatic secretion    Fat digestion and absorption   
NDEx NetworkPLA2G12A
Atlas of Cancer Signalling NetworkPLA2G12A
Wikipedia pathwaysPLA2G12A
Orthology - Evolution
OrthoDB81579
GeneTree (enSembl)ENSG00000123739
Phylogenetic Trees/Animal Genes : TreeFamPLA2G12A
HOVERGENQ9BZM1
HOGENOMQ9BZM1
Homologs : HomoloGenePLA2G12A
Homology/Alignments : Family Browser (UCSC)PLA2G12A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G12A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G12A
dbVarPLA2G12A
ClinVarPLA2G12A
1000_GenomesPLA2G12A 
Exome Variant ServerPLA2G12A
ExAC (Exome Aggregation Consortium)PLA2G12A (select the gene name)
Genetic variants : HAPMAP81579
Genomic Variants (DGV)PLA2G12A [DGVbeta]
DECIPHER (Syndromes)4:110631145-110651242  ENSG00000123739
CONAN: Copy Number AnalysisPLA2G12A 
Mutations
ICGC Data PortalPLA2G12A 
TCGA Data PortalPLA2G12A 
Broad Tumor PortalPLA2G12A
OASIS PortalPLA2G12A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G12A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G12A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G12A
DgiDB (Drug Gene Interaction Database)PLA2G12A
DoCM (Curated mutations)PLA2G12A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G12A (select a term)
intoGenPLA2G12A
Cancer3DPLA2G12A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611652   
Orphanet
MedgenPLA2G12A
Genetic Testing Registry PLA2G12A
NextProtQ9BZM1 [Medical]
TSGene81579
GENETestsPLA2G12A
Huge Navigator PLA2G12A [HugePedia]
snp3D : Map Gene to Disease81579
BioCentury BCIQPLA2G12A
ClinGenPLA2G12A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81579
Chemical/Pharm GKB GenePA38347
Clinical trialPLA2G12A
Miscellaneous
canSAR (ICR)PLA2G12A (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G12A
EVEXPLA2G12A
GoPubMedPLA2G12A
iHOPPLA2G12A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:38:46 CET 2017

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