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PLA2G15 (phospholipase A2 group XV)

Identity

Alias_namesLYPLA3
lysophospholipase 3 (lysosomal phospholipase A2)
phospholipase A2, group XV
Alias_symbol (synonym)LLPL
GXVPLA2
Other aliasACS
LPLA2
HGNC (Hugo) PLA2G15
LocusID (NCBI) 23659
Atlas_Id 54539
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 68279247 and ends at 68294961 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NFATC3 (16q22.1) / PLA2G15 (16q22.1)PLA2G15 (16q22.1) / APBB2 (4p14)PLA2G15 (16q22.1) / CD82 (11p11.2)
SDF4 (1p36.33) / PLA2G15 (16q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G15   17163
Cards
Entrez_Gene (NCBI)PLA2G15  23659  phospholipase A2 group XV
AliasesACS; GXVPLA2; LLPL; LPLA2; 
LYPLA3
GeneCards (Weizmann)PLA2G15
Ensembl hg19 (Hinxton)ENSG00000103066 [Gene_View]  chr16:68279247-68294961 [Contig_View]  PLA2G15 [Vega]
Ensembl hg38 (Hinxton)ENSG00000103066 [Gene_View]  chr16:68279247-68294961 [Contig_View]  PLA2G15 [Vega]
ICGC DataPortalENSG00000103066
TCGA cBioPortalPLA2G15
AceView (NCBI)PLA2G15
Genatlas (Paris)PLA2G15
WikiGenes23659
SOURCE (Princeton)PLA2G15
Genetics Home Reference (NIH)PLA2G15
Genomic and cartography
GoldenPath hg19 (UCSC)PLA2G15  -     chr16:68279247-68294961 +  16q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLA2G15  -     16q22.1   [Description]    (hg38-Dec_2013)
EnsemblPLA2G15 - 16q22.1 [CytoView hg19]  PLA2G15 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIPLA2G15 [Mapview hg19]  PLA2G15 [Mapview hg38]
OMIM609362   
Gene and transcription
Genbank (Entrez)AB017494 AK001705 AK074828 AK127898 AK222790
RefSeq transcript (Entrez)NM_012320
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)PLA2G15
Cluster EST : UnigeneHs.632199 [ NCBI ]
CGAP (NCI)Hs.632199
Alternative Splicing GalleryENSG00000103066
Gene ExpressionPLA2G15 [ NCBI-GEO ]   PLA2G15 [ EBI - ARRAY_EXPRESS ]   PLA2G15 [ SEEK ]   PLA2G15 [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23659
GTEX Portal (Tissue expression)PLA2G15
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NCC3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NCC3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NCC3
Splice isoforms : SwissVarQ8NCC3
PhosPhoSitePlusQ8NCC3
Domains : Interpro (EBI)AB_hydrolase    LACT/PDAT_acylTrfase   
Domain families : Pfam (Sanger)LCAT (PF02450)   
Domain families : Pfam (NCBI)pfam02450   
Conserved Domain (NCBI)PLA2G15
DMDM Disease mutations23659
Blocks (Seattle)PLA2G15
PDB (SRS)4X90    4X91    4X92    4X93    4X94    4X95    4X97   
PDB (PDBSum)4X90    4X91    4X92    4X93    4X94    4X95    4X97   
PDB (IMB)4X90    4X91    4X92    4X93    4X94    4X95    4X97   
PDB (RSDB)4X90    4X91    4X92    4X93    4X94    4X95    4X97   
Structural Biology KnowledgeBase4X90    4X91    4X92    4X93    4X94    4X95    4X97   
SCOP (Structural Classification of Proteins)4X90    4X91    4X92    4X93    4X94    4X95    4X97   
CATH (Classification of proteins structures)4X90    4X91    4X92    4X93    4X94    4X95    4X97   
SuperfamilyQ8NCC3
Human Protein AtlasENSG00000103066
Peptide AtlasQ8NCC3
HPRD07128
IPIIPI00301459   IPI00908305   IPI00910263   
Protein Interaction databases
DIP (DOE-UCLA)Q8NCC3
IntAct (EBI)Q8NCC3
FunCoupENSG00000103066
BioGRIDPLA2G15
STRING (EMBL)PLA2G15
ZODIACPLA2G15
Ontologies - Pathways
QuickGOQ8NCC3
Ontology : AmiGOlysophospholipase activity  phospholipid binding  extracellular space  mitochondrion  lysosome  lysosome  glycerophospholipid metabolic process  ceramide metabolic process  ceramide metabolic process  O-acyltransferase activity  O-acyltransferase activity  fatty acid catabolic process  membrane  phosphatidylcholine catabolic process  phosphatidylethanolamine catabolic process  calcium-independent phospholipase A2 activity  extracellular exosome  
Ontology : EGO-EBIlysophospholipase activity  phospholipid binding  extracellular space  mitochondrion  lysosome  lysosome  glycerophospholipid metabolic process  ceramide metabolic process  ceramide metabolic process  O-acyltransferase activity  O-acyltransferase activity  fatty acid catabolic process  membrane  phosphatidylcholine catabolic process  phosphatidylethanolamine catabolic process  calcium-independent phospholipase A2 activity  extracellular exosome  
Pathways : KEGGGlycerophospholipid metabolism    Lysosome   
NDEx NetworkPLA2G15
Atlas of Cancer Signalling NetworkPLA2G15
Wikipedia pathwaysPLA2G15
Orthology - Evolution
OrthoDB23659
GeneTree (enSembl)ENSG00000103066
Phylogenetic Trees/Animal Genes : TreeFamPLA2G15
HOVERGENQ8NCC3
HOGENOMQ8NCC3
Homologs : HomoloGenePLA2G15
Homology/Alignments : Family Browser (UCSC)PLA2G15
Gene fusions - Rearrangements
Fusion : MitelmanNFATC3/PLA2G15 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G15
dbVarPLA2G15
ClinVarPLA2G15
1000_GenomesPLA2G15 
Exome Variant ServerPLA2G15
ExAC (Exome Aggregation Consortium)PLA2G15 (select the gene name)
Genetic variants : HAPMAP23659
Genomic Variants (DGV)PLA2G15 [DGVbeta]
DECIPHER (Syndromes)16:68279247-68294961  ENSG00000103066
CONAN: Copy Number AnalysisPLA2G15 
Mutations
ICGC Data PortalPLA2G15 
TCGA Data PortalPLA2G15 
Broad Tumor PortalPLA2G15
OASIS PortalPLA2G15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G15
DgiDB (Drug Gene Interaction Database)PLA2G15
DoCM (Curated mutations)PLA2G15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G15 (select a term)
intoGenPLA2G15
Cancer3DPLA2G15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609362   
Orphanet
MedgenPLA2G15
Genetic Testing Registry PLA2G15
NextProtQ8NCC3 [Medical]
TSGene23659
GENETestsPLA2G15
Huge Navigator PLA2G15 [HugePedia]
snp3D : Map Gene to Disease23659
BioCentury BCIQPLA2G15
ClinGenPLA2G15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23659
Chemical/Pharm GKB GenePA164724567
Clinical trialPLA2G15
Miscellaneous
canSAR (ICR)PLA2G15 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G15
EVEXPLA2G15
GoPubMedPLA2G15
iHOPPLA2G15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:21:37 CET 2017

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