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PLA2G1B (phospholipase A2 group IB)

Identity

Alias_namesPLA2
PPLA2
PLA2A
phospholipase A2
Other alias
HGNC (Hugo) PLA2G1B
LocusID (NCBI) 5319
Atlas_Id 54540
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 120322111 and ends at 120327789 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GCN1 (12q24.23) / PLA2G1B (12q24.31)LAMA3 (18q11.2) / PLA2G1B (12q24.31)PLA2G1B (12q24.31) / TIPIN (15q22.31)
PXN (12q24.23) / PLA2G1B (12q24.31)TUBGCP3 (13q34) / PLA2G1B (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G1B   9030
Cards
Entrez_Gene (NCBI)PLA2G1B  5319  phospholipase A2 group IB
AliasesPLA2; PLA2A; PPLA2
GeneCards (Weizmann)PLA2G1B
Ensembl hg19 (Hinxton)ENSG00000170890 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170890 [Gene_View]  chr12:120322111-120327789 [Contig_View]  PLA2G1B [Vega]
ICGC DataPortalENSG00000170890
TCGA cBioPortalPLA2G1B
AceView (NCBI)PLA2G1B
Genatlas (Paris)PLA2G1B
WikiGenes5319
SOURCE (Princeton)PLA2G1B
Genetics Home Reference (NIH)PLA2G1B
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G1B  -     chr12:120322111-120327789 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G1B  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblPLA2G1B - 12q24.31 [CytoView hg19]  PLA2G1B - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIPLA2G1B [Mapview hg19]  PLA2G1B [Mapview hg38]
OMIM172410   
Gene and transcription
Genbank (Entrez)AA844927 AK311830 BC005386 BC013384 BC106725
RefSeq transcript (Entrez)NM_000928
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2G1B
Cluster EST : UnigeneHs.992 [ NCBI ]
CGAP (NCI)Hs.992
Alternative Splicing GalleryENSG00000170890
Gene ExpressionPLA2G1B [ NCBI-GEO ]   PLA2G1B [ EBI - ARRAY_EXPRESS ]   PLA2G1B [ SEEK ]   PLA2G1B [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5319
GTEX Portal (Tissue expression)PLA2G1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04054   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04054  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04054
Splice isoforms : SwissVarP04054
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusP04054
Domaine pattern : Prosite (Expaxy)PA2_ASP (PS00119)    PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2    PLipase_A2_Asp_AS    PLipase_A2_dom    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_1 (PF00068)   
Domain families : Pfam (NCBI)pfam00068   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)PLA2G1B
DMDM Disease mutations5319
Blocks (Seattle)PLA2G1B
PDB (SRS)1YSK    3ELO   
PDB (PDBSum)1YSK    3ELO   
PDB (IMB)1YSK    3ELO   
PDB (RSDB)1YSK    3ELO   
Structural Biology KnowledgeBase1YSK    3ELO   
SCOP (Structural Classification of Proteins)1YSK    3ELO   
CATH (Classification of proteins structures)1YSK    3ELO   
SuperfamilyP04054
Human Protein AtlasENSG00000170890
Peptide AtlasP04054
HPRD01396
IPIIPI00021792   IPI00029251   IPI01023050   
Protein Interaction databases
DIP (DOE-UCLA)P04054
IntAct (EBI)P04054
FunCoupENSG00000170890
BioGRIDPLA2G1B
STRING (EMBL)PLA2G1B
ZODIACPLA2G1B
Ontologies - Pathways
QuickGOP04054
Ontology : AmiGOactivation of MAPK activity  innate immune response in mucosa  neutrophil mediated immunity  phospholipase A2 activity  phospholipase A2 activity  receptor binding  receptor binding  calcium ion binding  extracellular region  extracellular space  cytosol  fatty acid biosynthetic process  phosphatidic acid biosynthetic process  actin filament organization  signal transduction  cell surface  positive regulation of calcium ion transport into cytosol  glucose transport  leukotriene biosynthetic process  antibacterial humoral response  secretory granule  neutrophil chemotaxis  bile acid binding  activation of phospholipase A2 activity  interleukin-8 production  cellular response to insulin stimulus  intracellular signal transduction  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  multicellular organismal lipid catabolic process  positive regulation of DNA replication  positive regulation of transcription from RNA polymerase II promoter  phosphatidylcholine metabolic process  calcium-dependent phospholipase A2 activity  positive regulation of fibroblast proliferation  arachidonic acid secretion  positive regulation of protein secretion  positive regulation of immune response  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  
Ontology : EGO-EBIactivation of MAPK activity  innate immune response in mucosa  neutrophil mediated immunity  phospholipase A2 activity  phospholipase A2 activity  receptor binding  receptor binding  calcium ion binding  extracellular region  extracellular space  cytosol  fatty acid biosynthetic process  phosphatidic acid biosynthetic process  actin filament organization  signal transduction  cell surface  positive regulation of calcium ion transport into cytosol  glucose transport  leukotriene biosynthetic process  antibacterial humoral response  secretory granule  neutrophil chemotaxis  bile acid binding  activation of phospholipase A2 activity  interleukin-8 production  cellular response to insulin stimulus  intracellular signal transduction  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  multicellular organismal lipid catabolic process  positive regulation of DNA replication  positive regulation of transcription from RNA polymerase II promoter  phosphatidylcholine metabolic process  calcium-dependent phospholipase A2 activity  positive regulation of fibroblast proliferation  arachidonic acid secretion  positive regulation of protein secretion  positive regulation of immune response  defense response to Gram-positive bacterium  positive regulation of NF-kappaB transcription factor activity  
Pathways : KEGG   
NDEx NetworkPLA2G1B
Atlas of Cancer Signalling NetworkPLA2G1B
Wikipedia pathwaysPLA2G1B
Orthology - Evolution
OrthoDB5319
GeneTree (enSembl)ENSG00000170890
Phylogenetic Trees/Animal Genes : TreeFamPLA2G1B
HOVERGENP04054
HOGENOMP04054
Homologs : HomoloGenePLA2G1B
Homology/Alignments : Family Browser (UCSC)PLA2G1B
Gene fusions - Rearrangements
Fusion : MitelmanGCN1L1/12q24.31 [PLA2G1B/t(12;12)(q24;q24)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G1B
dbVarPLA2G1B
ClinVarPLA2G1B
1000_GenomesPLA2G1B 
Exome Variant ServerPLA2G1B
ExAC (Exome Aggregation Consortium)PLA2G1B (select the gene name)
Genetic variants : HAPMAP5319
Genomic Variants (DGV)PLA2G1B [DGVbeta]
DECIPHERPLA2G1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G1B 
Mutations
ICGC Data PortalPLA2G1B 
TCGA Data PortalPLA2G1B 
Broad Tumor PortalPLA2G1B
OASIS PortalPLA2G1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G1B
DgiDB (Drug Gene Interaction Database)PLA2G1B
DoCM (Curated mutations)PLA2G1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G1B (select a term)
intoGenPLA2G1B
Cancer3DPLA2G1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM172410   
Orphanet
MedgenPLA2G1B
Genetic Testing Registry PLA2G1B
NextProtP04054 [Medical]
TSGene5319
GENETestsPLA2G1B
Target ValidationPLA2G1B
Huge Navigator PLA2G1B [HugePedia]
snp3D : Map Gene to Disease5319
BioCentury BCIQPLA2G1B
ClinGenPLA2G1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5319
Chemical/Pharm GKB GenePA33361
Clinical trialPLA2G1B
Miscellaneous
canSAR (ICR)PLA2G1B (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G1B
EVEXPLA2G1B
GoPubMedPLA2G1B
iHOPPLA2G1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:25:03 CEST 2017

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