Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PLA2G2D (phospholipase A2 group IID)

Identity

Alias_namesphospholipase A2
Alias_symbol (synonym)sPLA2S
Other aliasPLA2IID
SPLASH
sPLA2-IID
HGNC (Hugo) PLA2G2D
LocusID (NCBI) 26279
Atlas_Id 41731
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 20112650 and ends at 20119566 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLA2G2D (1p36.12) / SKAP1 (17q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLA2G2D   9033
Cards
Entrez_Gene (NCBI)PLA2G2D  26279  phospholipase A2 group IID
AliasesPLA2IID; SPLASH; sPLA2-IID; sPLA2S
GeneCards (Weizmann)PLA2G2D
Ensembl hg19 (Hinxton)ENSG00000117215 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117215 [Gene_View]  chr1:20112650-20119566 [Contig_View]  PLA2G2D [Vega]
ICGC DataPortalENSG00000117215
TCGA cBioPortalPLA2G2D
AceView (NCBI)PLA2G2D
Genatlas (Paris)PLA2G2D
WikiGenes26279
SOURCE (Princeton)PLA2G2D
Genetics Home Reference (NIH)PLA2G2D
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G2D  -     chr1:20112650-20119566 -  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G2D  -     1p36.12   [Description]    (hg19-Feb_2009)
EnsemblPLA2G2D - 1p36.12 [CytoView hg19]  PLA2G2D - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIPLA2G2D [Mapview hg19]  PLA2G2D [Mapview hg38]
OMIM605630   
Gene and transcription
Genbank (Entrez)AF112982 AF188625 AK026347 AK290406 AK301396
RefSeq transcript (Entrez)NM_001271814 NM_012400
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2G2D
Cluster EST : UnigeneHs.189507 [ NCBI ]
CGAP (NCI)Hs.189507
Alternative Splicing GalleryENSG00000117215
Gene ExpressionPLA2G2D [ NCBI-GEO ]   PLA2G2D [ EBI - ARRAY_EXPRESS ]   PLA2G2D [ SEEK ]   PLA2G2D [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G2D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26279
GTEX Portal (Tissue expression)PLA2G2D
Human Protein AtlasENSG00000117215-PLA2G2D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNK4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNK4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNK4
Splice isoforms : SwissVarQ9UNK4
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ9UNK4
Domaine pattern : Prosite (Expaxy)PA2_ASP (PS00119)    PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2    PLipase_A2_Asp_AS    PLipase_A2_dom    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_1 (PF00068)   
Domain families : Pfam (NCBI)pfam00068   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)PLA2G2D
DMDM Disease mutations26279
Blocks (Seattle)PLA2G2D
SuperfamilyQ9UNK4
Human Protein Atlas [tissue]ENSG00000117215-PLA2G2D [tissue]
Peptide AtlasQ9UNK4
HPRD07546
IPIIPI00018259   IPI00432402   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNK4
IntAct (EBI)Q9UNK4
FunCoupENSG00000117215
BioGRIDPLA2G2D
STRING (EMBL)PLA2G2D
ZODIACPLA2G2D
Ontologies - Pathways
QuickGOQ9UNK4
Ontology : AmiGOCD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  phospholipase A2 activity  calcium ion binding  extracellular region  phospholipid metabolic process  phosphatidic acid biosynthetic process  inflammatory response  heparin binding  lipid catabolic process  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  negative regulation of T cell proliferation  heparan sulfate proteoglycan binding  arachidonic acid secretion  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
Ontology : EGO-EBICD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  phospholipase A2 activity  calcium ion binding  extracellular region  phospholipid metabolic process  phosphatidic acid biosynthetic process  inflammatory response  heparin binding  lipid catabolic process  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  negative regulation of T cell proliferation  heparan sulfate proteoglycan binding  arachidonic acid secretion  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
Pathways : KEGGLong-term depression    VEGF signaling pathway    Glycerophospholipid metabolism    MAPK signaling pathway    GnRH signaling pathway    Linoleic acid metabolism    Arachidonic acid metabolism    Fc epsilon RI signaling pathway   
NDEx NetworkPLA2G2D
Atlas of Cancer Signalling NetworkPLA2G2D
Wikipedia pathwaysPLA2G2D
Orthology - Evolution
OrthoDB26279
GeneTree (enSembl)ENSG00000117215
Phylogenetic Trees/Animal Genes : TreeFamPLA2G2D
HOVERGENQ9UNK4
HOGENOMQ9UNK4
Homologs : HomoloGenePLA2G2D
Homology/Alignments : Family Browser (UCSC)PLA2G2D
Gene fusions - Rearrangements
Fusion : QuiverPLA2G2D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G2D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G2D
dbVarPLA2G2D
ClinVarPLA2G2D
1000_GenomesPLA2G2D 
Exome Variant ServerPLA2G2D
ExAC (Exome Aggregation Consortium)ENSG00000117215
GNOMAD BrowserENSG00000117215
Genetic variants : HAPMAP26279
Genomic Variants (DGV)PLA2G2D [DGVbeta]
DECIPHERPLA2G2D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G2D 
Mutations
ICGC Data PortalPLA2G2D 
TCGA Data PortalPLA2G2D 
Broad Tumor PortalPLA2G2D
OASIS PortalPLA2G2D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G2D  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G2D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G2D
DgiDB (Drug Gene Interaction Database)PLA2G2D
DoCM (Curated mutations)PLA2G2D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G2D (select a term)
intoGenPLA2G2D
Cancer3DPLA2G2D(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605630   
Orphanet
DisGeNETPLA2G2D
MedgenPLA2G2D
Genetic Testing Registry PLA2G2D
NextProtQ9UNK4 [Medical]
TSGene26279
GENETestsPLA2G2D
Target ValidationPLA2G2D
Huge Navigator PLA2G2D [HugePedia]
snp3D : Map Gene to Disease26279
BioCentury BCIQPLA2G2D
ClinGenPLA2G2D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26279
Chemical/Pharm GKB GenePA33363
Clinical trialPLA2G2D
Miscellaneous
canSAR (ICR)PLA2G2D (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G2D
EVEXPLA2G2D
GoPubMedPLA2G2D
iHOPPLA2G2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:30:56 CET 2018
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