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PLA2G2E (phospholipase A2 group IIE)

Identity

Alias_namesphospholipase A2
Other aliasGIIE sPLA2
sPLA2-IIE
HGNC (Hugo) PLA2G2E
LocusID (NCBI) 30814
Atlas_Id 41732
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 19920307 and ends at 19923617 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G2E   13414
Cards
Entrez_Gene (NCBI)PLA2G2E  30814  phospholipase A2 group IIE
AliasesGIIE; sPLA2-IIE
GeneCards (Weizmann)PLA2G2E
Ensembl hg19 (Hinxton)ENSG00000188784 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188784 [Gene_View]  chr1:19920307-19923617 [Contig_View]  PLA2G2E [Vega]
ICGC DataPortalENSG00000188784
TCGA cBioPortalPLA2G2E
AceView (NCBI)PLA2G2E
Genatlas (Paris)PLA2G2E
WikiGenes30814
SOURCE (Princeton)PLA2G2E
Genetics Home Reference (NIH)PLA2G2E
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G2E  -     chr1:19920307-19923617 -  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G2E  -     1p36.13   [Description]    (hg19-Feb_2009)
EnsemblPLA2G2E - 1p36.13 [CytoView hg19]  PLA2G2E - 1p36.13 [CytoView hg38]
Mapping of homologs : NCBIPLA2G2E [Mapview hg19]  PLA2G2E [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF189279 BC069116 BC140240 BC141619
RefSeq transcript (Entrez)NM_014589
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2G2E
Cluster EST : UnigeneHs.272372 [ NCBI ]
CGAP (NCI)Hs.272372
Alternative Splicing GalleryENSG00000188784
Gene ExpressionPLA2G2E [ NCBI-GEO ]   PLA2G2E [ EBI - ARRAY_EXPRESS ]   PLA2G2E [ SEEK ]   PLA2G2E [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G2E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30814
GTEX Portal (Tissue expression)PLA2G2E
Human Protein AtlasENSG00000188784-PLA2G2E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZK7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZK7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZK7
Splice isoforms : SwissVarQ9NZK7
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ9NZK7
Domaine pattern : Prosite (Expaxy)PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2    PLipase_A2_dom    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_1 (PF00068)   
Domain families : Pfam (NCBI)pfam00068   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)PLA2G2E
DMDM Disease mutations30814
Blocks (Seattle)PLA2G2E
SuperfamilyQ9NZK7
Human Protein Atlas [tissue]ENSG00000188784-PLA2G2E [tissue]
Peptide AtlasQ9NZK7
HPRD07143
IPIIPI00005553   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZK7
IntAct (EBI)Q9NZK7
FunCoupENSG00000188784
BioGRIDPLA2G2E
STRING (EMBL)PLA2G2E
ZODIACPLA2G2E
Ontologies - Pathways
QuickGOQ9NZK7
Ontology : AmiGOphospholipase A2 activity  calcium ion binding  extracellular region  phospholipid metabolic process  phosphatidic acid biosynthetic process  inflammatory response  lipid catabolic process  low-density lipoprotein particle remodeling  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  arachidonic acid secretion  
Ontology : EGO-EBIphospholipase A2 activity  calcium ion binding  extracellular region  phospholipid metabolic process  phosphatidic acid biosynthetic process  inflammatory response  lipid catabolic process  low-density lipoprotein particle remodeling  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  arachidonic acid secretion  
Pathways : KEGG   
NDEx NetworkPLA2G2E
Atlas of Cancer Signalling NetworkPLA2G2E
Wikipedia pathwaysPLA2G2E
Orthology - Evolution
OrthoDB30814
GeneTree (enSembl)ENSG00000188784
Phylogenetic Trees/Animal Genes : TreeFamPLA2G2E
HOVERGENQ9NZK7
HOGENOMQ9NZK7
Homologs : HomoloGenePLA2G2E
Homology/Alignments : Family Browser (UCSC)PLA2G2E
Gene fusions - Rearrangements
Tumor Fusion PortalPLA2G2E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G2E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G2E
dbVarPLA2G2E
ClinVarPLA2G2E
1000_GenomesPLA2G2E 
Exome Variant ServerPLA2G2E
ExAC (Exome Aggregation Consortium)ENSG00000188784
GNOMAD BrowserENSG00000188784
Genetic variants : HAPMAP30814
Genomic Variants (DGV)PLA2G2E [DGVbeta]
DECIPHERPLA2G2E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G2E 
Mutations
ICGC Data PortalPLA2G2E 
TCGA Data PortalPLA2G2E 
Broad Tumor PortalPLA2G2E
OASIS PortalPLA2G2E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G2E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G2E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G2E
DgiDB (Drug Gene Interaction Database)PLA2G2E
DoCM (Curated mutations)PLA2G2E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G2E (select a term)
intoGenPLA2G2E
Cancer3DPLA2G2E(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPLA2G2E
MedgenPLA2G2E
Genetic Testing Registry PLA2G2E
NextProtQ9NZK7 [Medical]
TSGene30814
GENETestsPLA2G2E
Target ValidationPLA2G2E
Huge Navigator PLA2G2E [HugePedia]
snp3D : Map Gene to Disease30814
BioCentury BCIQPLA2G2E
ClinGenPLA2G2E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30814
Chemical/Pharm GKB GenePA134889019
Clinical trialPLA2G2E
Miscellaneous
canSAR (ICR)PLA2G2E (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G2E
EVEXPLA2G2E
GoPubMedPLA2G2E
iHOPPLA2G2E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:29:01 CET 2017

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