Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLA2G3 (phospholipase A2 group III)

Identity

Alias_namesphospholipase A2
Alias_symbol (synonym)GIII-SPLA2
Other aliasSPLA2III
sPLA2-III
HGNC (Hugo) PLA2G3
LocusID (NCBI) 50487
Atlas_Id 46392
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 31530793 and ends at 31536593 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G3   17934
Cards
Entrez_Gene (NCBI)PLA2G3  50487  phospholipase A2 group III
AliasesGIII-SPLA2; SPLA2III; sPLA2-III
GeneCards (Weizmann)PLA2G3
Ensembl hg19 (Hinxton)ENSG00000100078 [Gene_View]  chr22:31530793-31536593 [Contig_View]  PLA2G3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100078 [Gene_View]  chr22:31530793-31536593 [Contig_View]  PLA2G3 [Vega]
ICGC DataPortalENSG00000100078
TCGA cBioPortalPLA2G3
AceView (NCBI)PLA2G3
Genatlas (Paris)PLA2G3
WikiGenes50487
SOURCE (Princeton)PLA2G3
Genetics Home Reference (NIH)PLA2G3
Genomic and cartography
GoldenPath hg19 (UCSC)PLA2G3  -     chr22:31530793-31536593 -  22q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLA2G3  -     22q12.2   [Description]    (hg38-Dec_2013)
EnsemblPLA2G3 - 22q12.2 [CytoView hg19]  PLA2G3 - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBIPLA2G3 [Mapview hg19]  PLA2G3 [Mapview hg38]
OMIM611651   
Gene and transcription
Genbank (Entrez)AF220490 BC025316 DQ892832 DQ896078
RefSeq transcript (Entrez)NM_015715
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)PLA2G3
Cluster EST : UnigeneHs.149623 [ NCBI ]
CGAP (NCI)Hs.149623
Alternative Splicing GalleryENSG00000100078
Gene ExpressionPLA2G3 [ NCBI-GEO ]   PLA2G3 [ EBI - ARRAY_EXPRESS ]   PLA2G3 [ SEEK ]   PLA2G3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50487
GTEX Portal (Tissue expression)PLA2G3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZ20   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZ20  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZ20
Splice isoforms : SwissVarQ9NZ20
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ9NZ20
Domaine pattern : Prosite (Expaxy)PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2_dom    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_2 (PF05826)   
Domain families : Pfam (NCBI)pfam05826   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)PLA2G3
DMDM Disease mutations50487
Blocks (Seattle)PLA2G3
SuperfamilyQ9NZ20
Human Protein AtlasENSG00000100078
Peptide AtlasQ9NZ20
HPRD07144
IPIIPI00024578   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZ20
IntAct (EBI)Q9NZ20
FunCoupENSG00000100078
BioGRIDPLA2G3
STRING (EMBL)PLA2G3
ZODIACPLA2G3
Ontologies - Pathways
QuickGOQ9NZ20
Ontology : AmiGOacrosome assembly  phospholipase A2 activity  extracellular region  extracellular space  centriole  plasma membrane  phospholipid metabolic process  sperm axoneme assembly  lipid catabolic process  lipoxygenase pathway  phosphatidylglycerol acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  mast cell granule  mast cell degranulation  metal ion binding  calcium-dependent phospholipase A2 activity  cilium morphogenesis  
Ontology : EGO-EBIacrosome assembly  phospholipase A2 activity  extracellular region  extracellular space  centriole  plasma membrane  phospholipid metabolic process  sperm axoneme assembly  lipid catabolic process  lipoxygenase pathway  phosphatidylglycerol acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  mast cell granule  mast cell degranulation  metal ion binding  calcium-dependent phospholipase A2 activity  cilium morphogenesis  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    Ras signaling pathway    Vascular smooth muscle contraction    Pancreatic secretion    Fat digestion and absorption   
NDEx NetworkPLA2G3
Atlas of Cancer Signalling NetworkPLA2G3
Wikipedia pathwaysPLA2G3
Orthology - Evolution
OrthoDB50487
GeneTree (enSembl)ENSG00000100078
Phylogenetic Trees/Animal Genes : TreeFamPLA2G3
HOVERGENQ9NZ20
HOGENOMQ9NZ20
Homologs : HomoloGenePLA2G3
Homology/Alignments : Family Browser (UCSC)PLA2G3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G3
dbVarPLA2G3
ClinVarPLA2G3
1000_GenomesPLA2G3 
Exome Variant ServerPLA2G3
ExAC (Exome Aggregation Consortium)PLA2G3 (select the gene name)
Genetic variants : HAPMAP50487
Genomic Variants (DGV)PLA2G3 [DGVbeta]
DECIPHER (Syndromes)22:31530793-31536593  ENSG00000100078
CONAN: Copy Number AnalysisPLA2G3 
Mutations
ICGC Data PortalPLA2G3 
TCGA Data PortalPLA2G3 
Broad Tumor PortalPLA2G3
OASIS PortalPLA2G3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G3
DgiDB (Drug Gene Interaction Database)PLA2G3
DoCM (Curated mutations)PLA2G3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G3 (select a term)
intoGenPLA2G3
Cancer3DPLA2G3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611651   
Orphanet
MedgenPLA2G3
Genetic Testing Registry PLA2G3
NextProtQ9NZ20 [Medical]
TSGene50487
GENETestsPLA2G3
Huge Navigator PLA2G3 [HugePedia]
snp3D : Map Gene to Disease50487
BioCentury BCIQPLA2G3
ClinGenPLA2G3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50487
Chemical/Pharm GKB GenePA38267
Clinical trialPLA2G3
Miscellaneous
canSAR (ICR)PLA2G3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G3
EVEXPLA2G3
GoPubMedPLA2G3
iHOPPLA2G3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:14:34 CEST 2017

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