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PLA2G4B (phospholipase A2 group IVB)

Identity

Alias_namesphospholipase A2, group IVB (cytosolic)
Alias_symbol (synonym)cPLA2-beta
HsT16992
Other alias
HGNC (Hugo) PLA2G4B
LocusID (NCBI) 100137049
Atlas_Id 71954
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 41838813 and ends at 41848148 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
JMJD7 (15q15.1) / PLA2G4B (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G4B   9036
Cards
Entrez_Gene (NCBI)PLA2G4B  100137049  phospholipase A2 group IVB
AliasesHsT16992; cPLA2-beta
GeneCards (Weizmann)PLA2G4B
Ensembl hg19 (Hinxton)ENSG00000243708 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000243708 [Gene_View]  chr15:41838813-41848148 [Contig_View]  PLA2G4B [Vega]
ICGC DataPortalENSG00000243708
TCGA cBioPortalPLA2G4B
AceView (NCBI)PLA2G4B
Genatlas (Paris)PLA2G4B
WikiGenes100137049
SOURCE (Princeton)PLA2G4B
Genetics Home Reference (NIH)PLA2G4B
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G4B  -     chr15:41838813-41848148 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G4B  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblPLA2G4B - 15q15.1 [CytoView hg19]  PLA2G4B - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIPLA2G4B [Mapview hg19]  PLA2G4B [Mapview hg38]
OMIM606088   
Gene and transcription
Genbank (Entrez)AK124489 AK299419 AK310651 BF372565 BM982475
RefSeq transcript (Entrez)NM_001114633
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2G4B
Cluster EST : UnigeneHs.198161 [ NCBI ]
CGAP (NCI)Hs.198161
Alternative Splicing GalleryENSG00000243708
Gene ExpressionPLA2G4B [ NCBI-GEO ]   PLA2G4B [ EBI - ARRAY_EXPRESS ]   PLA2G4B [ SEEK ]   PLA2G4B [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)100137049
GTEX Portal (Tissue expression)PLA2G4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0C869   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0C869  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0C869
Splice isoforms : SwissVarP0C869
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusP0C869
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PLA2C (PS51210)   
Domains : Interpro (EBI)Acyl_Trfase/lysoPLipase    C2_dom    LysoPLipase_cat_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    PLA2_B (PF01735)   
Domain families : Pfam (NCBI)pfam00168    pfam01735   
Domain families : Smart (EMBL)C2 (SM00239)  PLAc (SM00022)  
Conserved Domain (NCBI)PLA2G4B
DMDM Disease mutations100137049
Blocks (Seattle)PLA2G4B
SuperfamilyP0C869
Human Protein AtlasENSG00000243708
Peptide AtlasP0C869
IPIIPI00413939   IPI00783406   IPI00382394   
Protein Interaction databases
DIP (DOE-UCLA)P0C869
IntAct (EBI)P0C869
FunCoupENSG00000243708
BioGRIDPLA2G4B
STRING (EMBL)PLA2G4B
ZODIACPLA2G4B
Ontologies - Pathways
QuickGOP0C869
Ontology : AmiGOlysophospholipase activity  lysophospholipase activity  phospholipase A2 activity  calcium ion binding  calcium-dependent phospholipid binding  extracellular region  mitochondrial inner membrane  cytosol  cytosol  phospholipid metabolic process  phosphatidic acid biosynthetic process  inflammatory response  parturition  phosphatidylcholine 1-acylhydrolase activity  arachidonic acid metabolic process  calcium-mediated signaling  early endosome membrane  phosphatidylglycerol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  IRE1-mediated unfolded protein response  glycerophospholipid catabolic process  calcium-dependent phospholipase A2 activity  
Ontology : EGO-EBIlysophospholipase activity  lysophospholipase activity  phospholipase A2 activity  calcium ion binding  calcium-dependent phospholipid binding  extracellular region  mitochondrial inner membrane  cytosol  cytosol  phospholipid metabolic process  phosphatidic acid biosynthetic process  inflammatory response  parturition  phosphatidylcholine 1-acylhydrolase activity  arachidonic acid metabolic process  calcium-mediated signaling  early endosome membrane  phosphatidylglycerol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  IRE1-mediated unfolded protein response  glycerophospholipid catabolic process  calcium-dependent phospholipase A2 activity  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    MAPK signaling pathway    Ras signaling pathway    Vascular smooth muscle contraction    VEGF signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Glutamatergic synapse    Serotonergic synapse    Long-term depression    GnRH signaling pathway    Ovarian steroidogenesis   
NDEx NetworkPLA2G4B
Atlas of Cancer Signalling NetworkPLA2G4B
Wikipedia pathwaysPLA2G4B
Orthology - Evolution
OrthoDB100137049
GeneTree (enSembl)ENSG00000243708
Phylogenetic Trees/Animal Genes : TreeFamPLA2G4B
HOVERGENP0C869
HOGENOMP0C869
Homologs : HomoloGenePLA2G4B
Homology/Alignments : Family Browser (UCSC)PLA2G4B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G4B
dbVarPLA2G4B
ClinVarPLA2G4B
1000_GenomesPLA2G4B 
Exome Variant ServerPLA2G4B
ExAC (Exome Aggregation Consortium)PLA2G4B (select the gene name)
Genetic variants : HAPMAP100137049
Genomic Variants (DGV)PLA2G4B [DGVbeta]
DECIPHERPLA2G4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G4B 
Mutations
ICGC Data PortalPLA2G4B 
TCGA Data PortalPLA2G4B 
Broad Tumor PortalPLA2G4B
OASIS PortalPLA2G4B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLA2G4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G4B
DgiDB (Drug Gene Interaction Database)PLA2G4B
DoCM (Curated mutations)PLA2G4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G4B (select a term)
intoGenPLA2G4B
Cancer3DPLA2G4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606088   
Orphanet
MedgenPLA2G4B
Genetic Testing Registry PLA2G4B
NextProtP0C869 [Medical]
TSGene100137049
GENETestsPLA2G4B
Target ValidationPLA2G4B
Huge Navigator PLA2G4B [HugePedia]
snp3D : Map Gene to Disease100137049
BioCentury BCIQPLA2G4B
ClinGenPLA2G4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD100137049
Chemical/Pharm GKB GenePA33364
Clinical trialPLA2G4B
Miscellaneous
canSAR (ICR)PLA2G4B (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G4B
EVEXPLA2G4B
GoPubMedPLA2G4B
iHOPPLA2G4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:34:39 CEST 2017

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