Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLA2G4C (phospholipase A2 group IVC)

Identity

Alias_namesphospholipase A2
Alias_symbol (synonym)cPLA2-gamma
Other aliasCPLA2-gamma
HGNC (Hugo) PLA2G4C
LocusID (NCBI) 8605
Atlas_Id 46175
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 48551100 and ends at 48614109 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G4C   9037
Cards
Entrez_Gene (NCBI)PLA2G4C  8605  phospholipase A2 group IVC
AliasesCPLA2-gamma
GeneCards (Weizmann)PLA2G4C
Ensembl hg19 (Hinxton)ENSG00000105499 [Gene_View]  chr19:48551100-48614109 [Contig_View]  PLA2G4C [Vega]
Ensembl hg38 (Hinxton)ENSG00000105499 [Gene_View]  chr19:48551100-48614109 [Contig_View]  PLA2G4C [Vega]
ICGC DataPortalENSG00000105499
TCGA cBioPortalPLA2G4C
AceView (NCBI)PLA2G4C
Genatlas (Paris)PLA2G4C
WikiGenes8605
SOURCE (Princeton)PLA2G4C
Genetics Home Reference (NIH)PLA2G4C
Genomic and cartography
GoldenPath hg19 (UCSC)PLA2G4C  -     chr19:48551100-48614109 -  19q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLA2G4C  -     19q13.33   [Description]    (hg38-Dec_2013)
EnsemblPLA2G4C - 19q13.33 [CytoView hg19]  PLA2G4C - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIPLA2G4C [Mapview hg19]  PLA2G4C [Mapview hg38]
OMIM603602   
Gene and transcription
Genbank (Entrez)AF058921 AF065214 AK022440 AK124241 AK126152
RefSeq transcript (Entrez)NM_001159322 NM_001159323 NM_003706
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_016021 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)PLA2G4C
Cluster EST : UnigeneHs.631562 [ NCBI ]
CGAP (NCI)Hs.631562
Alternative Splicing GalleryENSG00000105499
Gene ExpressionPLA2G4C [ NCBI-GEO ]   PLA2G4C [ EBI - ARRAY_EXPRESS ]   PLA2G4C [ SEEK ]   PLA2G4C [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G4C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8605
GTEX Portal (Tissue expression)PLA2G4C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UP65   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UP65  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UP65
Splice isoforms : SwissVarQ9UP65
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ9UP65
Domaine pattern : Prosite (Expaxy)PLA2C (PS51210)   
Domains : Interpro (EBI)Acyl_Trfase/lysoPLipase    LysoPLipase_cat_dom   
Domain families : Pfam (Sanger)PLA2_B (PF01735)   
Domain families : Pfam (NCBI)pfam01735   
Domain families : Smart (EMBL)PLAc (SM00022)  
Conserved Domain (NCBI)PLA2G4C
DMDM Disease mutations8605
Blocks (Seattle)PLA2G4C
SuperfamilyQ9UP65
Human Protein AtlasENSG00000105499
Peptide AtlasQ9UP65
HPRD04673
IPIIPI00910091   IPI00929100   IPI00929453   
Protein Interaction databases
DIP (DOE-UCLA)Q9UP65
IntAct (EBI)Q9UP65
FunCoupENSG00000105499
BioGRIDPLA2G4C
STRING (EMBL)PLA2G4C
ZODIACPLA2G4C
Ontologies - Pathways
QuickGOQ9UP65
Ontology : AmiGOlysophospholipase activity  phospholipase A2 activity  phospholipid binding  nuclear envelope  nucleoplasm  endoplasmic reticulum membrane  cytosol  cell cortex  phospholipid metabolic process  inflammatory response  parturition  phosphatidylcholine 1-acylhydrolase activity  membrane  arachidonic acid metabolic process  intracellular signal transduction  phosphatidylinositol acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  glycerophospholipid catabolic process  calcium-independent phospholipase A2 activity  
Ontology : EGO-EBIlysophospholipase activity  phospholipase A2 activity  phospholipid binding  nuclear envelope  nucleoplasm  endoplasmic reticulum membrane  cytosol  cell cortex  phospholipid metabolic process  inflammatory response  parturition  phosphatidylcholine 1-acylhydrolase activity  membrane  arachidonic acid metabolic process  intracellular signal transduction  phosphatidylinositol acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  glycerophospholipid catabolic process  calcium-independent phospholipase A2 activity  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    MAPK signaling pathway    Ras signaling pathway    Vascular smooth muscle contraction    VEGF signaling pathway    Fc epsilon RI signaling pathway    Glutamatergic synapse    Serotonergic synapse    Long-term depression    GnRH signaling pathway    Ovarian steroidogenesis   
NDEx NetworkPLA2G4C
Atlas of Cancer Signalling NetworkPLA2G4C
Wikipedia pathwaysPLA2G4C
Orthology - Evolution
OrthoDB8605
GeneTree (enSembl)ENSG00000105499
Phylogenetic Trees/Animal Genes : TreeFamPLA2G4C
HOVERGENQ9UP65
HOGENOMQ9UP65
Homologs : HomoloGenePLA2G4C
Homology/Alignments : Family Browser (UCSC)PLA2G4C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G4C
dbVarPLA2G4C
ClinVarPLA2G4C
1000_GenomesPLA2G4C 
Exome Variant ServerPLA2G4C
ExAC (Exome Aggregation Consortium)PLA2G4C (select the gene name)
Genetic variants : HAPMAP8605
Genomic Variants (DGV)PLA2G4C [DGVbeta]
DECIPHER (Syndromes)19:48551100-48614109  ENSG00000105499
CONAN: Copy Number AnalysisPLA2G4C 
Mutations
ICGC Data PortalPLA2G4C 
TCGA Data PortalPLA2G4C 
Broad Tumor PortalPLA2G4C
OASIS PortalPLA2G4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G4C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G4C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G4C
DgiDB (Drug Gene Interaction Database)PLA2G4C
DoCM (Curated mutations)PLA2G4C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G4C (select a term)
intoGenPLA2G4C
Cancer3DPLA2G4C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603602   
Orphanet
MedgenPLA2G4C
Genetic Testing Registry PLA2G4C
NextProtQ9UP65 [Medical]
TSGene8605
GENETestsPLA2G4C
Huge Navigator PLA2G4C [HugePedia]
snp3D : Map Gene to Disease8605
BioCentury BCIQPLA2G4C
ClinGenPLA2G4C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8605
Chemical/Pharm GKB GenePA33365
Clinical trialPLA2G4C
Miscellaneous
canSAR (ICR)PLA2G4C (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G4C
EVEXPLA2G4C
GoPubMedPLA2G4C
iHOPPLA2G4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:14:34 CEST 2017

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