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PLA2G4D (phospholipase A2 group IVD)

Identity

Alias (NCBI)cPLA2delta
HGNC (Hugo) PLA2G4D
HGNC Alias symbcPLA2delta
HGNC Previous namephospholipase A2, group IVD (cytosolic)
LocusID (NCBI) 283748
Atlas_Id 71955
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 42067009 and ends at 42094562 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLA2G4D   30038
Cards
Entrez_Gene (NCBI)PLA2G4D    phospholipase A2 group IVD
AliasescPLA2delta
GeneCards (Weizmann)PLA2G4D
Ensembl hg19 (Hinxton)ENSG00000159337 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159337 [Gene_View]  ENSG00000159337 [Sequence]  chr15:42067009-42094562 [Contig_View]  PLA2G4D [Vega]
ICGC DataPortalENSG00000159337
TCGA cBioPortalPLA2G4D
AceView (NCBI)PLA2G4D
Genatlas (Paris)PLA2G4D
SOURCE (Princeton)PLA2G4D
Genetics Home Reference (NIH)PLA2G4D
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G4D  -     chr15:42067009-42094562 -  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G4D  -     15q15.1   [Description]    (hg19-Feb_2009)
GoldenPathPLA2G4D - 15q15.1 [CytoView hg19]  PLA2G4D - 15q15.1 [CytoView hg38]
ImmunoBaseENSG00000159337
Genome Data Viewer NCBIPLA2G4D [Mapview hg19]  
OMIM612864   
Gene and transcription
Genbank (Entrez)AB090876 BC034571
RefSeq transcript (Entrez)NM_178034
Consensus coding sequences : CCDS (NCBI)PLA2G4D
Gene ExpressionPLA2G4D [ NCBI-GEO ]   PLA2G4D [ EBI - ARRAY_EXPRESS ]   PLA2G4D [ SEEK ]   PLA2G4D [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G4D [ Firebrowse - Broad ]
GenevisibleExpression of PLA2G4D in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283748
GTEX Portal (Tissue expression)PLA2G4D
Human Protein AtlasENSG00000159337-PLA2G4D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86XP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86XP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86XP0
PhosPhoSitePlusQ86XP0
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PLA2C (PS51210)   
Domains : Interpro (EBI)Acyl_Trfase/lysoPLipase    C2_cPLA2    C2_dom    C2_domain_sf    cPLA2_C2    LysoPLipase_cat_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    cPLA2_C2 (PF18695)    PLA2_B (PF01735)   
Domain families : Pfam (NCBI)pfam00168    pfam18695    pfam01735   
Domain families : Smart (EMBL)C2 (SM00239)  PLAc (SM00022)  
Conserved Domain (NCBI)PLA2G4D
PDB (RSDB)5IXC    5IZ5    5IZR   
PDB Europe5IXC    5IZ5    5IZR   
PDB (PDBSum)5IXC    5IZ5    5IZR   
PDB (IMB)5IXC    5IZ5    5IZR   
Structural Biology KnowledgeBase5IXC    5IZ5    5IZR   
SCOP (Structural Classification of Proteins)5IXC    5IZ5    5IZR   
CATH (Classification of proteins structures)5IXC    5IZ5    5IZR   
SuperfamilyQ86XP0
AlphaFold pdb e-kbQ86XP0   
Human Protein Atlas [tissue]ENSG00000159337-PLA2G4D [tissue]
HPRD07145
Protein Interaction databases
DIP (DOE-UCLA)Q86XP0
IntAct (EBI)Q86XP0
BioGRIDPLA2G4D
STRING (EMBL)PLA2G4D
ZODIACPLA2G4D
Ontologies - Pathways
QuickGOQ86XP0
Ontology : AmiGOphospholipase A2 activity  calcium ion binding  calcium-dependent phospholipid binding  cytosol  cytosol  fatty acid metabolic process  phospholipid metabolic process  phosphatidic acid biosynthetic process  membrane  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  glycerophospholipid catabolic process  glycerophospholipid catabolic process  calcium-dependent phospholipase A2 activity  calcium-dependent phospholipase A2 activity  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
Ontology : EGO-EBIphospholipase A2 activity  calcium ion binding  calcium-dependent phospholipid binding  cytosol  cytosol  fatty acid metabolic process  phospholipid metabolic process  phosphatidic acid biosynthetic process  membrane  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  glycerophospholipid catabolic process  glycerophospholipid catabolic process  calcium-dependent phospholipase A2 activity  calcium-dependent phospholipase A2 activity  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
NDEx NetworkPLA2G4D
Atlas of Cancer Signalling NetworkPLA2G4D
Wikipedia pathwaysPLA2G4D
Orthology - Evolution
OrthoDB283748
GeneTree (enSembl)ENSG00000159337
Phylogenetic Trees/Animal Genes : TreeFamPLA2G4D
Homologs : HomoloGenePLA2G4D
Homology/Alignments : Family Browser (UCSC)PLA2G4D
Gene fusions - Rearrangements
Fusion : QuiverPLA2G4D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G4D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G4D
dbVarPLA2G4D
ClinVarPLA2G4D
MonarchPLA2G4D
1000_GenomesPLA2G4D 
Exome Variant ServerPLA2G4D
GNOMAD BrowserENSG00000159337
Varsome BrowserPLA2G4D
ACMGPLA2G4D variants
VarityQ86XP0
Genomic Variants (DGV)PLA2G4D [DGVbeta]
DECIPHERPLA2G4D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G4D 
Mutations
ICGC Data PortalPLA2G4D 
TCGA Data PortalPLA2G4D 
Broad Tumor PortalPLA2G4D
OASIS PortalPLA2G4D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G4D  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLA2G4D
Mutations and Diseases : HGMDPLA2G4D
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLA2G4D
DgiDB (Drug Gene Interaction Database)PLA2G4D
DoCM (Curated mutations)PLA2G4D
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G4D
Cancer3DPLA2G4D
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612864   
Orphanet
DisGeNETPLA2G4D
MedgenPLA2G4D
Genetic Testing Registry PLA2G4D
NextProtQ86XP0 [Medical]
GENETestsPLA2G4D
Target ValidationPLA2G4D
Huge Navigator PLA2G4D [HugePedia]
ClinGenPLA2G4D
Clinical trials, drugs, therapy
MyCancerGenomePLA2G4D
Protein Interactions : CTDPLA2G4D
Pharm GKB GenePA134974074
PharosQ86XP0
Clinical trialPLA2G4D
Miscellaneous
canSAR (ICR)PLA2G4D
HarmonizomePLA2G4D
DataMed IndexPLA2G4D
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLA2G4D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:16:21 CEST 2021

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