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PLA2G4E (phospholipase A2 group IVE)

Identity

Alias_namesphospholipase A2, group IVE
Alias_symbol (synonym)FLJ45651
Other alias-
HGNC (Hugo) PLA2G4E
LocusID (NCBI) 123745
Atlas_Id 71956
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 41981582 and ends at 42050703 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G4E   24791
Cards
Entrez_Gene (NCBI)PLA2G4E  123745  phospholipase A2 group IVE
Aliases
GeneCards (Weizmann)PLA2G4E
Ensembl hg19 (Hinxton)ENSG00000188089 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188089 [Gene_View]  chr15:41981582-42050703 [Contig_View]  PLA2G4E [Vega]
ICGC DataPortalENSG00000188089
TCGA cBioPortalPLA2G4E
AceView (NCBI)PLA2G4E
Genatlas (Paris)PLA2G4E
WikiGenes123745
SOURCE (Princeton)PLA2G4E
Genetics Home Reference (NIH)PLA2G4E
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G4E  -     chr15:41981582-42050703 -  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G4E  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblPLA2G4E - 15q15.1 [CytoView hg19]  PLA2G4E - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIPLA2G4E [Mapview hg19]  PLA2G4E [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI224165 AK127558 BC101584 BC101612 BC143436
RefSeq transcript (Entrez)NM_001080490 NM_001206670
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2G4E
Cluster EST : UnigeneHs.668060 [ NCBI ]
CGAP (NCI)Hs.668060
Alternative Splicing GalleryENSG00000188089
Gene ExpressionPLA2G4E [ NCBI-GEO ]   PLA2G4E [ EBI - ARRAY_EXPRESS ]   PLA2G4E [ SEEK ]   PLA2G4E [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G4E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)123745
GTEX Portal (Tissue expression)PLA2G4E
Human Protein AtlasENSG00000188089-PLA2G4E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ3MJ16   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ3MJ16  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ3MJ16
Splice isoforms : SwissVarQ3MJ16
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ3MJ16
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PLA2C (PS51210)   
Domains : Interpro (EBI)Acyl_Trfase/lysoPLipase    C2_dom    LysoPLipase_cat_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    PLA2_B (PF01735)   
Domain families : Pfam (NCBI)pfam00168    pfam01735   
Domain families : Smart (EMBL)C2 (SM00239)  PLAc (SM00022)  
Conserved Domain (NCBI)PLA2G4E
DMDM Disease mutations123745
Blocks (Seattle)PLA2G4E
SuperfamilyQ3MJ16
Human Protein Atlas [tissue]ENSG00000188089-PLA2G4E [tissue]
Peptide AtlasQ3MJ16
HPRD13510
IPIIPI00936735   IPI00942942   
Protein Interaction databases
DIP (DOE-UCLA)Q3MJ16
IntAct (EBI)Q3MJ16
FunCoupENSG00000188089
BioGRIDPLA2G4E
STRING (EMBL)PLA2G4E
ZODIACPLA2G4E
Ontologies - Pathways
QuickGOQ3MJ16
Ontology : AmiGOlysophospholipase activity  phospholipase A2 activity  lysosome  lysosomal membrane  cytosol  phospholipid metabolic process  phosphatidylcholine 1-acylhydrolase activity  phospholipid catabolic process  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  metal ion binding  
Ontology : EGO-EBIlysophospholipase activity  phospholipase A2 activity  lysosome  lysosomal membrane  cytosol  phospholipid metabolic process  phosphatidylcholine 1-acylhydrolase activity  phospholipid catabolic process  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  metal ion binding  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    MAPK signaling pathway    Ras signaling pathway    Vascular smooth muscle contraction    VEGF signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Glutamatergic synapse    Serotonergic synapse    Long-term depression    GnRH signaling pathway    Ovarian steroidogenesis   
NDEx NetworkPLA2G4E
Atlas of Cancer Signalling NetworkPLA2G4E
Wikipedia pathwaysPLA2G4E
Orthology - Evolution
OrthoDB123745
GeneTree (enSembl)ENSG00000188089
Phylogenetic Trees/Animal Genes : TreeFamPLA2G4E
HOVERGENQ3MJ16
HOGENOMQ3MJ16
Homologs : HomoloGenePLA2G4E
Homology/Alignments : Family Browser (UCSC)PLA2G4E
Gene fusions - Rearrangements
Tumor Fusion PortalPLA2G4E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G4E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G4E
dbVarPLA2G4E
ClinVarPLA2G4E
1000_GenomesPLA2G4E 
Exome Variant ServerPLA2G4E
ExAC (Exome Aggregation Consortium)ENSG00000188089
GNOMAD BrowserENSG00000188089
Genetic variants : HAPMAP123745
Genomic Variants (DGV)PLA2G4E [DGVbeta]
DECIPHERPLA2G4E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G4E 
Mutations
ICGC Data PortalPLA2G4E 
TCGA Data PortalPLA2G4E 
Broad Tumor PortalPLA2G4E
OASIS PortalPLA2G4E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G4E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G4E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G4E
DgiDB (Drug Gene Interaction Database)PLA2G4E
DoCM (Curated mutations)PLA2G4E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G4E (select a term)
intoGenPLA2G4E
Cancer3DPLA2G4E(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPLA2G4E
MedgenPLA2G4E
Genetic Testing Registry PLA2G4E
NextProtQ3MJ16 [Medical]
TSGene123745
GENETestsPLA2G4E
Target ValidationPLA2G4E
Huge Navigator PLA2G4E [HugePedia]
snp3D : Map Gene to Disease123745
BioCentury BCIQPLA2G4E
ClinGenPLA2G4E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD123745
Chemical/Pharm GKB GenePA142671169
Clinical trialPLA2G4E
Miscellaneous
canSAR (ICR)PLA2G4E (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G4E
EVEXPLA2G4E
GoPubMedPLA2G4E
iHOPPLA2G4E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Nov 20 20:07:21 CET 2017

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