PLA2G7 (phospholipase A2 group VII)

2011-06-01 Affiliation

Identity

HGNC

PLA2G7

LOCATION

6p12.3

LOCUSID

7941

ALIAS

LDL-PLA2,LP-PLA2,PAFAD,PAFAH

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7941
MIM: 601690
HGNC: 9040
Ensembl: ENSG00000146070

Variants:

dbSNP: 7941
ClinVar: 7941
TCGA: ENSG00000146070
COSMIC: PLA2G7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000146070	ENST00000274793	Q13093
ENSG00000146070	ENST00000537365	Q13093

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ether lipid metabolism	KEGG	ko00565
Ether lipid metabolism	KEGG	hsa00565
Metabolic pathways	KEGG	hsa01100
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Synthesis, secretion, and deacylation of Ghrelin	REACTOME	R-HSA-422085

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16371369	2006	Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases.	65
17502572	2007	Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans.	63
22499993	2012	Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.	48
22665167	2012	Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2.	46
18356547	2008	Enhanced expression of Lp-PLA2 and lysophosphatidylcholine in symptomatic carotid atherosclerotic plaques.	42
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
18165686	2008	Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein.	38
16223884	2005	Lipoprotein-associated phospholipase A2 activity is a marker of small, dense LDL particles in human plasma.	37
19272461	2009	The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma.	35

Citation

Dessen P

PLA2G7 (phospholipase A2 group VII)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52252/pla2g7