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PLA2G7 (phospholipase A2 group VII)

Identity

Alias_namesphospholipase A2
Alias_symbol (synonym)PAFAH
LDL-PLA2
Other aliasLP-PLA2
PAFAD
HGNC (Hugo) PLA2G7
LocusID (NCBI) 7941
Atlas_Id 52252
Location 6p12.3  [Link to chromosome band 6p12]
Location_base_pair Starts at 46704316 and ends at 46735414 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLA2G7   9040
Cards
Entrez_Gene (NCBI)PLA2G7  7941  phospholipase A2 group VII
AliasesLDL-PLA2; LP-PLA2; PAFAD; PAFAH
GeneCards (Weizmann)PLA2G7
Ensembl hg19 (Hinxton)ENSG00000146070 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146070 [Gene_View]  ENSG00000146070 [Sequence]  chr6:46704316-46735414 [Contig_View]  PLA2G7 [Vega]
ICGC DataPortalENSG00000146070
TCGA cBioPortalPLA2G7
AceView (NCBI)PLA2G7
Genatlas (Paris)PLA2G7
WikiGenes7941
SOURCE (Princeton)PLA2G7
Genetics Home Reference (NIH)PLA2G7
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G7  -     chr6:46704316-46735414 -  6p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G7  -     6p12.3   [Description]    (hg19-Feb_2009)
EnsemblPLA2G7 - 6p12.3 [CytoView hg19]  PLA2G7 - 6p12.3 [CytoView hg38]
Mapping of homologs : NCBIPLA2G7 [Mapview hg19]  PLA2G7 [Mapview hg38]
OMIM147050   600807   601690   614278   
Gene and transcription
Genbank (Entrez)AK290381 AK294471 AK297066 BC025674 BC038452
RefSeq transcript (Entrez)NM_001168357 NM_005084
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2G7
Cluster EST : UnigeneHs.584823 [ NCBI ]
CGAP (NCI)Hs.584823
Alternative Splicing GalleryENSG00000146070
Gene ExpressionPLA2G7 [ NCBI-GEO ]   PLA2G7 [ EBI - ARRAY_EXPRESS ]   PLA2G7 [ SEEK ]   PLA2G7 [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7941
GTEX Portal (Tissue expression)PLA2G7
Human Protein AtlasENSG00000146070-PLA2G7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13093   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13093  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13093
Splice isoforms : SwissVarQ13093
Catalytic activity : Enzyme3.1.1.47 [ Enzyme-Expasy ]   3.1.1.473.1.1.47 [ IntEnz-EBI ]   3.1.1.47 [ BRENDA ]   3.1.1.47 [ KEGG ]   
PhosPhoSitePlusQ13093
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)   
Domains : Interpro (EBI)AB_hydrolase    PAF_acetylhydro-like    PAF_acetylhydro_eukaryote   
Domain families : Pfam (Sanger)PAF-AH_p_II (PF03403)   
Domain families : Pfam (NCBI)pfam03403   
Conserved Domain (NCBI)PLA2G7
DMDM Disease mutations7941
Blocks (Seattle)PLA2G7
PDB (SRS)3D59    3D5E    3F96    3F97    3F98    3F9C    5I8P    5I9I    5JAD    5JAH    5JAL    5JAN    5JAO    5JAP    5JAR    5JAS    5JAT    5JAU    5LP1    5LYY    5LZ2    5LZ4    5LZ5    5LZ7    5LZ8    5LZ9   
PDB (PDBSum)3D59    3D5E    3F96    3F97    3F98    3F9C    5I8P    5I9I    5JAD    5JAH    5JAL    5JAN    5JAO    5JAP    5JAR    5JAS    5JAT    5JAU    5LP1    5LYY    5LZ2    5LZ4    5LZ5    5LZ7    5LZ8    5LZ9   
PDB (IMB)3D59    3D5E    3F96    3F97    3F98    3F9C    5I8P    5I9I    5JAD    5JAH    5JAL    5JAN    5JAO    5JAP    5JAR    5JAS    5JAT    5JAU    5LP1    5LYY    5LZ2    5LZ4    5LZ5    5LZ7    5LZ8    5LZ9   
PDB (RSDB)3D59    3D5E    3F96    3F97    3F98    3F9C    5I8P    5I9I    5JAD    5JAH    5JAL    5JAN    5JAO    5JAP    5JAR    5JAS    5JAT    5JAU    5LP1    5LYY    5LZ2    5LZ4    5LZ5    5LZ7    5LZ8    5LZ9   
Structural Biology KnowledgeBase3D59    3D5E    3F96    3F97    3F98    3F9C    5I8P    5I9I    5JAD    5JAH    5JAL    5JAN    5JAO    5JAP    5JAR    5JAS    5JAT    5JAU    5LP1    5LYY    5LZ2    5LZ4    5LZ5    5LZ7    5LZ8    5LZ9   
SCOP (Structural Classification of Proteins)3D59    3D5E    3F96    3F97    3F98    3F9C    5I8P    5I9I    5JAD    5JAH    5JAL    5JAN    5JAO    5JAP    5JAR    5JAS    5JAT    5JAU    5LP1    5LYY    5LZ2    5LZ4    5LZ5    5LZ7    5LZ8    5LZ9   
CATH (Classification of proteins structures)3D59    3D5E    3F96    3F97    3F98    3F9C    5I8P    5I9I    5JAD    5JAH    5JAL    5JAN    5JAO    5JAP    5JAR    5JAS    5JAT    5JAU    5LP1    5LYY    5LZ2    5LZ4    5LZ5    5LZ7    5LZ8    5LZ9   
SuperfamilyQ13093
Human Protein Atlas [tissue]ENSG00000146070-PLA2G7 [tissue]
Peptide AtlasQ13093
HPRD03407
IPIIPI00011588   IPI01014627   IPI01010133   
Protein Interaction databases
DIP (DOE-UCLA)Q13093
IntAct (EBI)Q13093
FunCoupENSG00000146070
BioGRIDPLA2G7
STRING (EMBL)PLA2G7
ZODIACPLA2G7
Ontologies - Pathways
QuickGOQ13093
Ontology : AmiGO1-alkyl-2-acetylglycerophosphocholine esterase activity  phospholipid binding  extracellular region  cytoplasm  lipid catabolic process  hydrolase activity, acting on ester bonds  low-density lipoprotein particle  low-density lipoprotein particle remodeling  lipid oxidation  plasma lipoprotein particle oxidation  platelet activating factor metabolic process  calcium-independent phospholipase A2 activity  positive regulation of inflammatory response  positive regulation of monocyte chemotaxis  
Ontology : EGO-EBI1-alkyl-2-acetylglycerophosphocholine esterase activity  phospholipid binding  extracellular region  cytoplasm  lipid catabolic process  hydrolase activity, acting on ester bonds  low-density lipoprotein particle  low-density lipoprotein particle remodeling  lipid oxidation  plasma lipoprotein particle oxidation  platelet activating factor metabolic process  calcium-independent phospholipase A2 activity  positive regulation of inflammatory response  positive regulation of monocyte chemotaxis  
Pathways : KEGGGlycerophospholipid metabolism   
NDEx NetworkPLA2G7
Atlas of Cancer Signalling NetworkPLA2G7
Wikipedia pathwaysPLA2G7
Orthology - Evolution
OrthoDB7941
GeneTree (enSembl)ENSG00000146070
Phylogenetic Trees/Animal Genes : TreeFamPLA2G7
HOVERGENQ13093
HOGENOMQ13093
Homologs : HomoloGenePLA2G7
Homology/Alignments : Family Browser (UCSC)PLA2G7
Gene fusions - Rearrangements
Fusion : QuiverPLA2G7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G7
dbVarPLA2G7
ClinVarPLA2G7
1000_GenomesPLA2G7 
Exome Variant ServerPLA2G7
ExAC (Exome Aggregation Consortium)ENSG00000146070
GNOMAD BrowserENSG00000146070
Genetic variants : HAPMAP7941
Genomic Variants (DGV)PLA2G7 [DGVbeta]
DECIPHERPLA2G7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G7 
Mutations
ICGC Data PortalPLA2G7 
TCGA Data PortalPLA2G7 
Broad Tumor PortalPLA2G7
OASIS PortalPLA2G7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2G7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G7
DgiDB (Drug Gene Interaction Database)PLA2G7
DoCM (Curated mutations)PLA2G7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G7 (select a term)
intoGenPLA2G7
Cancer3DPLA2G7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147050    600807    601690    614278   
Orphanet
DisGeNETPLA2G7
MedgenPLA2G7
Genetic Testing Registry PLA2G7
NextProtQ13093 [Medical]
TSGene7941
GENETestsPLA2G7
Target ValidationPLA2G7
Huge Navigator PLA2G7 [HugePedia]
snp3D : Map Gene to Disease7941
BioCentury BCIQPLA2G7
ClinGenPLA2G7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7941
Chemical/Pharm GKB GenePA33368
Clinical trialPLA2G7
Miscellaneous
canSAR (ICR)PLA2G7 (select the gene name)
Probes
Litterature
PubMed249 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G7
EVEXPLA2G7
GoPubMedPLA2G7
iHOPPLA2G7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:43:19 CEST 2018

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