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PLA2R1 (phospholipase A2 receptor 1)

Identity

Alias_namesphospholipase A2 receptor 1, 180kD
phospholipase A2 receptor 1, 180kDa
Alias_symbol (synonym)PLA2G1R
PLA2IR
PLA2-R
CLEC13C
Other aliasPLA2R
HGNC (Hugo) PLA2R1
LocusID (NCBI) 22925
Atlas_Id 51021
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 159940749 and ends at 160062615 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLA2R1 (2q24.2) / CRK (17p13.3)PLA2R1 (2q24.2) / ITGB6 (2q24.2)PLA2R1 (2q24.2) / RBMS1 (2q24.2)
PLA2R1 RBMS1PLA2R1 2q24.2 / ITGB6 2q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  del(2)(q24q24) PLA2R1/RBMS1
PLA2R1/ITGB6 (2q24)


External links

Nomenclature
HGNC (Hugo)PLA2R1   9042
Cards
Entrez_Gene (NCBI)PLA2R1  22925  phospholipase A2 receptor 1
AliasesCLEC13C; PLA2-R; PLA2G1R; PLA2IR; 
PLA2R
GeneCards (Weizmann)PLA2R1
Ensembl hg19 (Hinxton)ENSG00000153246 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153246 [Gene_View]  ENSG00000153246 [Sequence]  chr2:159940749-160062615 [Contig_View]  PLA2R1 [Vega]
ICGC DataPortalENSG00000153246
TCGA cBioPortalPLA2R1
AceView (NCBI)PLA2R1
Genatlas (Paris)PLA2R1
WikiGenes22925
SOURCE (Princeton)PLA2R1
Genetics Home Reference (NIH)PLA2R1
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2R1  -     chr2:159940749-160062615 -  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2R1  -     2q24.2   [Description]    (hg19-Feb_2009)
EnsemblPLA2R1 - 2q24.2 [CytoView hg19]  PLA2R1 - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBIPLA2R1 [Mapview hg19]  PLA2R1 [Mapview hg38]
OMIM604939   
Gene and transcription
Genbank (Entrez)AI672072 AL598405 BC140823 BC144631 BF725498
RefSeq transcript (Entrez)NM_001007267 NM_001195641 NM_007366
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2R1
Cluster EST : UnigeneHs.410477 [ NCBI ]
CGAP (NCI)Hs.410477
Alternative Splicing GalleryENSG00000153246
Gene ExpressionPLA2R1 [ NCBI-GEO ]   PLA2R1 [ EBI - ARRAY_EXPRESS ]   PLA2R1 [ SEEK ]   PLA2R1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2R1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22925
GTEX Portal (Tissue expression)PLA2R1
Human Protein AtlasENSG00000153246-PLA2R1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13018   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13018  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13018
Splice isoforms : SwissVarQ13018
PhosPhoSitePlusQ13018
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)    FN2_1 (PS00023)    FN2_2 (PS51092)    RICIN_B_LECTIN (PS50231)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link_sf    C-type_lectin_CS    CTDL_fold    FN_type2_dom    FN_type2_sf    Ricin_B-like_lectins    Ricin_B_lectin   
Domain families : Pfam (Sanger)fn2 (PF00040)    Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00040    pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  FN2 (SM00059)  RICIN (SM00458)  
Conserved Domain (NCBI)PLA2R1
DMDM Disease mutations22925
Blocks (Seattle)PLA2R1
SuperfamilyQ13018
Human Protein Atlas [tissue]ENSG00000153246-PLA2R1 [tissue]
Peptide AtlasQ13018
HPRD09222
IPIIPI00105353   IPI00480099   IPI00983970   
Protein Interaction databases
DIP (DOE-UCLA)Q13018
IntAct (EBI)Q13018
FunCoupENSG00000153246
BioGRIDPLA2R1
STRING (EMBL)PLA2R1
ZODIACPLA2R1
Ontologies - Pathways
QuickGOQ13018
Ontology : AmiGOcytokine production  transmembrane signaling receptor activity  extracellular region  plasma membrane  receptor-mediated endocytosis  cell surface  integral component of membrane  carbohydrate binding  receptor complex  phospholipase binding  positive regulation of DNA damage response, signal transduction by p53 class mediator  reactive oxygen species metabolic process  positive regulation of arachidonic acid secretion  replicative senescence  oxidative stress-induced premature senescence  negative regulation of phospholipase A2 activity  negative regulation of arachidonic acid secretion  
Ontology : EGO-EBIcytokine production  transmembrane signaling receptor activity  extracellular region  plasma membrane  receptor-mediated endocytosis  cell surface  integral component of membrane  carbohydrate binding  receptor complex  phospholipase binding  positive regulation of DNA damage response, signal transduction by p53 class mediator  reactive oxygen species metabolic process  positive regulation of arachidonic acid secretion  replicative senescence  oxidative stress-induced premature senescence  negative regulation of phospholipase A2 activity  negative regulation of arachidonic acid secretion  
Pathways : KEGGPhagosome    Tuberculosis   
NDEx NetworkPLA2R1
Atlas of Cancer Signalling NetworkPLA2R1
Wikipedia pathwaysPLA2R1
Orthology - Evolution
OrthoDB22925
GeneTree (enSembl)ENSG00000153246
Phylogenetic Trees/Animal Genes : TreeFamPLA2R1
HOVERGENQ13018
HOGENOMQ13018
Homologs : HomoloGenePLA2R1
Homology/Alignments : Family Browser (UCSC)PLA2R1
Gene fusions - Rearrangements
Fusion : MitelmanPLA2R1/ITGB6 [2q24.2/2q24.2]  
Fusion : MitelmanPLA2R1/RBMS1 [2q24.2/2q24.2]  [del(2)(q24q24)]  
Fusion PortalPLA2R1 2q24.2 ITGB6 2q24.2 HNSC
Fusion : QuiverPLA2R1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2R1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2R1
dbVarPLA2R1
ClinVarPLA2R1
1000_GenomesPLA2R1 
Exome Variant ServerPLA2R1
ExAC (Exome Aggregation Consortium)ENSG00000153246
GNOMAD BrowserENSG00000153246
Varsome BrowserPLA2R1
Genetic variants : HAPMAP22925
Genomic Variants (DGV)PLA2R1 [DGVbeta]
DECIPHERPLA2R1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2R1 
Mutations
ICGC Data PortalPLA2R1 
TCGA Data PortalPLA2R1 
Broad Tumor PortalPLA2R1
OASIS PortalPLA2R1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2R1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLA2R1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2R1
DgiDB (Drug Gene Interaction Database)PLA2R1
DoCM (Curated mutations)PLA2R1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2R1 (select a term)
intoGenPLA2R1
Cancer3DPLA2R1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604939   
Orphanet
DisGeNETPLA2R1
MedgenPLA2R1
Genetic Testing Registry PLA2R1
NextProtQ13018 [Medical]
TSGene22925
GENETestsPLA2R1
Target ValidationPLA2R1
Huge Navigator PLA2R1 [HugePedia]
snp3D : Map Gene to Disease22925
BioCentury BCIQPLA2R1
ClinGenPLA2R1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22925
Chemical/Pharm GKB GenePA33369
Clinical trialPLA2R1
Miscellaneous
canSAR (ICR)PLA2R1 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2R1
EVEXPLA2R1
GoPubMedPLA2R1
iHOPPLA2R1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:30:24 CET 2018

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