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PLAA (phospholipase A2 activating protein)

Identity

Alias_symbol (synonym)PLAP
PLA2P
FLJ11281
FLJ12699
DOA1
Other alias
HGNC (Hugo) PLAA
LocusID (NCBI) 9373
Atlas_Id 41735
Location 9p21.2  [Link to chromosome band 9p21]
Location_base_pair Starts at 26903370 and ends at 26947470 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EGR3 (8p21.3) / PLAA (9p21.2)PLAA (9p21.2) / HACD4 (9p21.3)PLAA (9p21.2) / RUSC2 (9p13.3)
PLAA 9p21.2 PTPLAD2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PLAA   9043
Cards
Entrez_Gene (NCBI)PLAA  9373  phospholipase A2 activating protein
AliasesDOA1; PLA2P; PLAP
GeneCards (Weizmann)PLAA
Ensembl hg19 (Hinxton)ENSG00000137055 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137055 [Gene_View]  chr9:26903370-26947470 [Contig_View]  PLAA [Vega]
ICGC DataPortalENSG00000137055
TCGA cBioPortalPLAA
AceView (NCBI)PLAA
Genatlas (Paris)PLAA
WikiGenes9373
SOURCE (Princeton)PLAA
Genetics Home Reference (NIH)PLAA
Genomic and cartography
GoldenPath hg38 (UCSC)PLAA  -     chr9:26903370-26947470 -  9p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLAA  -     9p21.2   [Description]    (hg19-Feb_2009)
EnsemblPLAA - 9p21.2 [CytoView hg19]  PLAA - 9p21.2 [CytoView hg38]
Mapping of homologs : NCBIPLAA [Mapview hg19]  PLAA [Mapview hg38]
OMIM603873   
Gene and transcription
Genbank (Entrez)AF083395 AF145020 AJ238243 AK001642 AK002143
RefSeq transcript (Entrez)NM_001031689 NM_001321546 NM_004253
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLAA
Cluster EST : UnigeneHs.27182 [ NCBI ]
CGAP (NCI)Hs.27182
Alternative Splicing GalleryENSG00000137055
Gene ExpressionPLAA [ NCBI-GEO ]   PLAA [ EBI - ARRAY_EXPRESS ]   PLAA [ SEEK ]   PLAA [ MEM ]
Gene Expression Viewer (FireBrowse)PLAA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9373
GTEX Portal (Tissue expression)PLAA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y263   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y263  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y263
Splice isoforms : SwissVarQ9Y263
PhosPhoSitePlusQ9Y263
Domaine pattern : Prosite (Expaxy)PFU (PS51394)    PUL (PS51396)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)ARM-type_fold    PLAA/Doa1/Lub1    PLAA_fam_Ub-bd_PFU    PUL_dom    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)PFU (PF09070)    PUL (PF08324)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam09070    pfam08324    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PLAA
DMDM Disease mutations9373
Blocks (Seattle)PLAA
PDB (SRS)2K89    2K8A    2K8B    2K8C    3EBB   
PDB (PDBSum)2K89    2K8A    2K8B    2K8C    3EBB   
PDB (IMB)2K89    2K8A    2K8B    2K8C    3EBB   
PDB (RSDB)2K89    2K8A    2K8B    2K8C    3EBB   
Structural Biology KnowledgeBase2K89    2K8A    2K8B    2K8C    3EBB   
SCOP (Structural Classification of Proteins)2K89    2K8A    2K8B    2K8C    3EBB   
CATH (Classification of proteins structures)2K89    2K8A    2K8B    2K8C    3EBB   
SuperfamilyQ9Y263
Human Protein AtlasENSG00000137055
Peptide AtlasQ9Y263
HPRD04850
IPIIPI00218465   IPI00976725   IPI00980213   IPI00976151   IPI00983139   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y263
IntAct (EBI)Q9Y263
FunCoupENSG00000137055
BioGRIDPLAA
STRING (EMBL)PLAA
ZODIACPLAA
Ontologies - Pathways
QuickGOQ9Y263
Ontology : AmiGOprotein binding  nucleus  cytoplasm  phospholipid metabolic process  inflammatory response  signal transduction  ubiquitin homeostasis  phospholipase A2 activator activity  positive regulation of catalytic activity  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  extracellular exosome  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  phospholipid metabolic process  inflammatory response  signal transduction  ubiquitin homeostasis  phospholipase A2 activator activity  positive regulation of catalytic activity  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  extracellular exosome  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkPLAA
Atlas of Cancer Signalling NetworkPLAA
Wikipedia pathwaysPLAA
Orthology - Evolution
OrthoDB9373
GeneTree (enSembl)ENSG00000137055
Phylogenetic Trees/Animal Genes : TreeFamPLAA
HOVERGENQ9Y263
HOGENOMQ9Y263
Homologs : HomoloGenePLAA
Homology/Alignments : Family Browser (UCSC)PLAA
Gene fusions - Rearrangements
Fusion : MitelmanPLAA/HACD4 [9p21.2/9p21.3]  
Fusion : MitelmanPLAA/RUSC2 [9p21.2/9p13.3]  [t(9;9)(p13;p21)]  
Fusion: TCGAPLAA 9p21.2 PTPLAD2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLAA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLAA
dbVarPLAA
ClinVarPLAA
1000_GenomesPLAA 
Exome Variant ServerPLAA
ExAC (Exome Aggregation Consortium)PLAA (select the gene name)
Genetic variants : HAPMAP9373
Genomic Variants (DGV)PLAA [DGVbeta]
DECIPHERPLAA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLAA 
Mutations
ICGC Data PortalPLAA 
TCGA Data PortalPLAA 
Broad Tumor PortalPLAA
OASIS PortalPLAA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLAA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLAA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLAA
DgiDB (Drug Gene Interaction Database)PLAA
DoCM (Curated mutations)PLAA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLAA (select a term)
intoGenPLAA
Cancer3DPLAA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603873   
Orphanet
MedgenPLAA
Genetic Testing Registry PLAA
NextProtQ9Y263 [Medical]
TSGene9373
GENETestsPLAA
Target ValidationPLAA
Huge Navigator PLAA [HugePedia]
snp3D : Map Gene to Disease9373
BioCentury BCIQPLAA
ClinGenPLAA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9373
Chemical/Pharm GKB GenePA33370
Clinical trialPLAA
Miscellaneous
canSAR (ICR)PLAA (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLAA
EVEXPLAA
GoPubMedPLAA
iHOPPLAA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:25:05 CEST 2017

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