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PLAAT3 (phospholipase A and acyltransferase 3)

Identity

Alias_namesHRASLS3
PLA2G16
HRAS-like suppressor 3
phospholipase A2, group XVI
phospholipase A2 group XVI
Alias_symbol (synonym)HREV107
H-REV107-1
HREV107-3
MGC118754.
AdPLA
PLAAT-3
Other aliasH-REV107
HREV107-1
HRSL3
HGNC (Hugo) PLAAT3
LocusID (NCBI) 11145
Atlas_Id 40864
Location 11q12.3-q13.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 63574471 and ends at 63614437 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)PLAAT3   17825
Cards
Entrez_Gene (NCBI)PLAAT3  11145  phospholipase A and acyltransferase 3
AliasesAdPLA; H-REV107; H-REV107-1; HRASLS3; 
HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16; PLAAT-3
GeneCards (Weizmann)PLAAT3
Ensembl hg19 (Hinxton)ENSG00000176485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176485 [Gene_View]  ENSG00000176485 [Sequence]  chr11:63574471-63614437 [Contig_View]  PLAAT3 [Vega]
ICGC DataPortalENSG00000176485
TCGA cBioPortalPLAAT3
AceView (NCBI)PLAAT3
Genatlas (Paris)PLAAT3
WikiGenes11145
SOURCE (Princeton)PLAAT3
Genetics Home Reference (NIH)PLAAT3
Genomic and cartography
GoldenPath hg38 (UCSC)PLAAT3  -     chr11:63574471-63614437 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLAAT3  -     -   [Description]    (hg19-Feb_2009)
GoldenPathPLAAT3 - - [CytoView hg19]  PLAAT3 - - [CytoView hg38]
ImmunoBaseENSG00000176485
Mapping of homologs : NCBIPLAAT3 [Mapview hg19]  PLAAT3 [Mapview hg38]
OMIM613867   
Gene and transcription
Genbank (Entrez)AB030814 AB439591 AF317086 AI374456 AI590735
RefSeq transcript (Entrez)NM_001128203 NM_007069
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLAAT3
Cluster EST : UnigeneHs.502775 [ NCBI ]
CGAP (NCI)Hs.502775
Alternative Splicing GalleryENSG00000176485
Gene ExpressionPLAAT3 [ NCBI-GEO ]   PLAAT3 [ EBI - ARRAY_EXPRESS ]   PLAAT3 [ SEEK ]   PLAAT3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLAAT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11145
GTEX Portal (Tissue expression)PLAAT3
Human Protein AtlasENSG00000176485-PLAAT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53816   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53816  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53816
Splice isoforms : SwissVarP53816
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusP53816
Domains : Interpro (EBI)LRAT-like_dom   
Domain families : Pfam (Sanger)LRAT (PF04970)   
Domain families : Pfam (NCBI)pfam04970   
Conserved Domain (NCBI)PLAAT3
DMDM Disease mutations11145
Blocks (Seattle)PLAAT3
PDB (RSDB)2KYT    4DOT    4FA0    4Q95   
PDB Europe2KYT    4DOT    4FA0    4Q95   
PDB (PDBSum)2KYT    4DOT    4FA0    4Q95   
PDB (IMB)2KYT    4DOT    4FA0    4Q95   
Structural Biology KnowledgeBase2KYT    4DOT    4FA0    4Q95   
SCOP (Structural Classification of Proteins)2KYT    4DOT    4FA0    4Q95   
CATH (Classification of proteins structures)2KYT    4DOT    4FA0    4Q95   
SuperfamilyP53816
Human Protein Atlas [tissue]ENSG00000176485-PLAAT3 [tissue]
Peptide AtlasP53816
HPRD13671
IPIIPI00296480   IPI01018155   IPI00654727   
Protein Interaction databases
DIP (DOE-UCLA)P53816
IntAct (EBI)P53816
FunCoupENSG00000176485
BioGRIDPLAAT3
STRING (EMBL)PLAAT3
ZODIACPLAAT3
Ontologies - Pathways
QuickGOP53816
Ontology : AmiGOphospholipase A2 activity  protein binding  cellular_component  peroxisome  peroxisomal membrane  endoplasmic reticulum  cytosol  plasma membrane  triglyceride metabolic process  phospholipid metabolic process  peroxisome organization  phospholipid biosynthetic process  phospholipase A1 activity  response to bacterium  integral component of membrane  lipid catabolic process  N-acyltransferase activity  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  negative regulation of cell cycle  ether lipid metabolic process  perinuclear region of cytoplasm  phosphatidylserine 1-acylhydrolase activity  1-acyl-2-lysophosphatidylserine acylhydrolase activity  N-acylphosphatidylethanolamine metabolic process  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  regulation of adipose tissue development  
Ontology : EGO-EBIphospholipase A2 activity  protein binding  cellular_component  peroxisome  peroxisomal membrane  endoplasmic reticulum  cytosol  plasma membrane  triglyceride metabolic process  phospholipid metabolic process  peroxisome organization  phospholipid biosynthetic process  phospholipase A1 activity  response to bacterium  integral component of membrane  lipid catabolic process  N-acyltransferase activity  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  negative regulation of cell cycle  ether lipid metabolic process  perinuclear region of cytoplasm  phosphatidylserine 1-acylhydrolase activity  1-acyl-2-lysophosphatidylserine acylhydrolase activity  N-acylphosphatidylethanolamine metabolic process  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  regulation of adipose tissue development  
NDEx NetworkPLAAT3
Atlas of Cancer Signalling NetworkPLAAT3
Wikipedia pathwaysPLAAT3
Orthology - Evolution
OrthoDB11145
GeneTree (enSembl)ENSG00000176485
Phylogenetic Trees/Animal Genes : TreeFamPLAAT3
HOGENOMP53816
Homologs : HomoloGenePLAAT3
Homology/Alignments : Family Browser (UCSC)PLAAT3
Gene fusions - Rearrangements
Fusion : QuiverPLAAT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLAAT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLAAT3
dbVarPLAAT3
ClinVarPLAAT3
1000_GenomesPLAAT3 
Exome Variant ServerPLAAT3
ExAC (Exome Aggregation Consortium)ENSG00000176485
GNOMAD BrowserENSG00000176485
Varsome BrowserPLAAT3
Genetic variants : HAPMAP11145
Genomic Variants (DGV)PLAAT3 [DGVbeta]
DECIPHERPLAAT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLAAT3 
Mutations
ICGC Data PortalPLAAT3 
TCGA Data PortalPLAAT3 
Broad Tumor PortalPLAAT3
OASIS PortalPLAAT3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLAAT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLAAT3
DgiDB (Drug Gene Interaction Database)PLAAT3
DoCM (Curated mutations)PLAAT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLAAT3 (select a term)
intoGenPLAAT3
Cancer3DPLAAT3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613867   
Orphanet
DisGeNETPLAAT3
MedgenPLAAT3
Genetic Testing Registry PLAAT3
NextProtP53816 [Medical]
TSGene11145
GENETestsPLAAT3
Target ValidationPLAAT3
Huge Navigator PLAAT3 [HugePedia]
snp3D : Map Gene to Disease11145
BioCentury BCIQPLAAT3
ClinGenPLAAT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11145
Chemical/Pharm GKB GenePA164724584
Clinical trialPLAAT3
Miscellaneous
canSAR (ICR)PLAAT3 (select the gene name)
DataMed IndexPLAAT3
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLAAT3
EVEXPLAAT3
GoPubMedPLAAT3
iHOPPLAAT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 26 18:23:27 CEST 2019

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